Neurogranin: Difference between revisions
Jump to navigation
Jump to search
(ce) |
imported>Boghog (consistent citation formatting) |
||
| Line 20: | Line 20: | ||
'''Neurogranin''' is a [[calmodulin-binding proteins|calmodulin-binding protein]] expressed primarily in the brain, particularly in [[dendritic spine]]s, and participating in the [[protein kinase C]] signaling pathway. Neurogranin is the main postsynaptic protein regulating the availability of calmodulin, binding to it in the absence of [[calcium]]. [[Phosphorylation]] by protein kinase C lowers its binding ability. NRGN gene expression is controlled by [[thyroid]] hormones.<!-- | '''Neurogranin''' is a [[calmodulin-binding proteins|calmodulin-binding protein]] expressed primarily in the brain, particularly in [[dendritic spine]]s, and participating in the [[protein kinase C]] signaling pathway. Neurogranin is the main postsynaptic protein regulating the availability of calmodulin, binding to it in the absence of [[calcium]]. [[Phosphorylation]] by protein kinase C lowers its binding ability. NRGN gene expression is controlled by [[thyroid]] hormones.<!-- | ||
--><ref name="Arrieta_1999_thyroid">{{cite journal | | --><ref name="Arrieta_1999_thyroid">{{cite journal | vauthors = Martínez de Arrieta C, Morte B, Coloma A, Bernal J | title = The human RC3 gene homolog, NRGN contains a thyroid hormone-responsive element located in the first intron | journal = Endocrinology | volume = 140 | issue = 1 | pages = 335–43 | date = January 1999 | pmid = 9886843 | doi = 10.1210/en.140.1.335 }}</ref><!-- | ||
--> Human neurogranin consists of 78 [[amino acid]]s. | --> Human neurogranin consists of 78 [[amino acid]]s. | ||
| Line 26: | Line 26: | ||
One study tells of potential link of neurogranin gene to the heightened risk of [[schizophrenia]] in males,<!-- | One study tells of potential link of neurogranin gene to the heightened risk of [[schizophrenia]] in males,<!-- | ||
--><ref name="Ruano_2006_schiz_males">{{cite journal | | --><ref name="Ruano_2006_schiz_males">{{cite journal | vauthors = Ruano D, Aulchenko YS, Macedo A, Soares MJ, Valente J, Azevedo MH, Hutz MH, Gama CS, Lobato MI, Belmonte-de-Abreu P, Goodman AB, Pato C, Heutink P, Palha JA | title = Association of the gene encoding neurogranin with schizophrenia in males | journal = Journal of Psychiatric Research | volume = 42 | issue = 2 | pages = 125–33 | date = January 2008 | pmid = 17140601 | doi = 10.1016/j.jpsychires.2006.10.008 }}</ref><!-- | ||
--> another study gives evidence of lowered neurogranin [[immunoreactivity]] in the brains of people suffering from schizophrenia.<!-- | --> another study gives evidence of lowered neurogranin [[immunoreactivity]] in the brains of people suffering from schizophrenia.<!-- | ||
--><ref name="Broadbelt_2006_schiz_ir">{{cite journal | | --><ref name="Broadbelt_2006_schiz_ir">{{cite journal | vauthors = Broadbelt K, Ramprasaud A, Jones LB | title = Evidence of altered neurogranin immunoreactivity in areas 9 and 32 of schizophrenic prefrontal cortex | journal = Schizophrenia Research | volume = 87 | issue = 1–3 | pages = 6–14 | date = October 2006 | pmid = 16797925 | doi = 10.1016/j.schres.2006.04.028 }}</ref><!-- | ||
--> | --> | ||
| Line 36: | Line 36: | ||
Prior to its identification in the bovine and [[rat]] brain in 1991,<!-- | Prior to its identification in the bovine and [[rat]] brain in 1991,<!-- | ||
--><ref name="Baudier_1991_bovine_neurogranin">{{cite journal | | --><ref name="Baudier_1991_bovine_neurogranin">{{cite journal | vauthors = Baudier J, Deloulme JC, Van Dorsselaer A, Black D, Matthes HW | title = Purification and characterization of a brain-specific protein kinase C substrate, neurogranin (p17). Identification of a consensus amino acid sequence between neurogranin and neuromodulin (GAP43) that corresponds to the protein kinase C phosphorylation site and the calmodulin-binding domain | journal = The Journal of Biological Chemistry | volume = 266 | issue = 1 | pages = 229–37 | date = January 1991 | pmid = 1824695 }}</ref><!-- | ||
--> neurogranin was known as a putative protein kinase C-phosphorylated protein named p17. Human neurogranin was cloned in 1997 and turned out to be 96% identical to the rat protein.<!-- | --> neurogranin was known as a putative protein kinase C-phosphorylated protein named p17. Human neurogranin was cloned in 1997 and turned out to be 96% identical to the rat protein.<!-- | ||
--><ref name="Arrieta_1997_Human">{{cite journal | | --><ref name="Arrieta_1997_Human">{{cite journal | vauthors = Martínez de Arrieta C, Pérez Jurado L, Bernal J, Coloma A | title = Structure, organization, and chromosomal mapping of the human neurogranin gene (NRGN) | journal = Genomics | volume = 41 | issue = 2 | pages = 243–9 | date = April 1997 | pmid = 9143500 | doi = 10.1006/geno.1997.4622 }}</ref> | ||
==External links== | == References == | ||
{{reflist|32em}} | |||
== External links == | |||
* {{MeshName|Neurogranin}} | * {{MeshName|Neurogranin}} | ||
{{Nerve tissue protein}} | {{Nerve tissue protein}} | ||
{{biochemistry-stub}} | {{biochemistry-stub}} | ||
Latest revision as of 20:58, 6 February 2018
| neurogranin (protein kinase C substrate, RC3) | |
|---|---|
| Identifiers | |
| Symbol | NRGN |
| Entrez | 4900 |
| HUGO | 8000 |
| OMIM | 602350 |
| RefSeq | NM_006176 |
| UniProt | Q92686 |
| Other data | |
| Locus | Chr. 11 q24 |
Neurogranin is a calmodulin-binding protein expressed primarily in the brain, particularly in dendritic spines, and participating in the protein kinase C signaling pathway. Neurogranin is the main postsynaptic protein regulating the availability of calmodulin, binding to it in the absence of calcium. Phosphorylation by protein kinase C lowers its binding ability. NRGN gene expression is controlled by thyroid hormones.[1] Human neurogranin consists of 78 amino acids.
One study tells of potential link of neurogranin gene to the heightened risk of schizophrenia in males,[2] another study gives evidence of lowered neurogranin immunoreactivity in the brains of people suffering from schizophrenia.[3]
Prior to its identification in the bovine and rat brain in 1991,[4] neurogranin was known as a putative protein kinase C-phosphorylated protein named p17. Human neurogranin was cloned in 1997 and turned out to be 96% identical to the rat protein.[5]
References
- ↑ Martínez de Arrieta C, Morte B, Coloma A, Bernal J (January 1999). "The human RC3 gene homolog, NRGN contains a thyroid hormone-responsive element located in the first intron". Endocrinology. 140 (1): 335–43. doi:10.1210/en.140.1.335. PMID 9886843.
- ↑ Ruano D, Aulchenko YS, Macedo A, Soares MJ, Valente J, Azevedo MH, Hutz MH, Gama CS, Lobato MI, Belmonte-de-Abreu P, Goodman AB, Pato C, Heutink P, Palha JA (January 2008). "Association of the gene encoding neurogranin with schizophrenia in males". Journal of Psychiatric Research. 42 (2): 125–33. doi:10.1016/j.jpsychires.2006.10.008. PMID 17140601.
- ↑ Broadbelt K, Ramprasaud A, Jones LB (October 2006). "Evidence of altered neurogranin immunoreactivity in areas 9 and 32 of schizophrenic prefrontal cortex". Schizophrenia Research. 87 (1–3): 6–14. doi:10.1016/j.schres.2006.04.028. PMID 16797925.
- ↑ Baudier J, Deloulme JC, Van Dorsselaer A, Black D, Matthes HW (January 1991). "Purification and characterization of a brain-specific protein kinase C substrate, neurogranin (p17). Identification of a consensus amino acid sequence between neurogranin and neuromodulin (GAP43) that corresponds to the protein kinase C phosphorylation site and the calmodulin-binding domain". The Journal of Biological Chemistry. 266 (1): 229–37. PMID 1824695.
- ↑ Martínez de Arrieta C, Pérez Jurado L, Bernal J, Coloma A (April 1997). "Structure, organization, and chromosomal mapping of the human neurogranin gene (NRGN)". Genomics. 41 (2): 243–9. doi:10.1006/geno.1997.4622. PMID 9143500.
External links
- Neurogranin at the US National Library of Medicine Medical Subject Headings (MeSH)
| Stub icon | This biochemistry article is a stub. You can help Wikipedia by expanding it. |
.svg){kind=link}