Neurofibroma medical therapy: Difference between revisions
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==Medical Therapy== | ==Medical Therapy== | ||
'''Chemotherapy''' | '''Chemotherapy''' | ||
* Once a [[plexiform neurofibroma]] has undergone malignant transformation, [[chemotherapy]] can be used as treatment.<ref name=radio> Neurofibroma. Dr Bruno Di Muzio and Dr Maxime St-Amant et al. Radiopaedia.org 2015. http://radiopaedia.org/articles/neurofibroma </ref> | * Once a [[plexiform neurofibroma]] has undergone [[malignant transformation]], [[chemotherapy]] can be used as treatment.<ref name=radio> Neurofibroma. Dr Bruno Di Muzio and Dr Maxime St-Amant et al. Radiopaedia.org 2015. http://radiopaedia.org/articles/neurofibroma </ref> | ||
'''Radiation''' | '''Radiation''' | ||
* Radiation is generally not used as a treatment for plexiform | * [[Radiation]] is generally not used as a treatment for [[plexiform neurofibroma]]s because of concerns that this could actually promote malignant transformation. There has even been a documented case of a [[schwannoma]] being induced from a neurofibroma due to radiation therapy.<ref name=" pmid8998885">{{cite journal |author=Isler MH, Fogaça MF, Mankin HJ. |title=Radiation induced malignant schwannoma arising in a neurofibroma |journal=Clinical Orthopaedics and Related Research |issue=325 |pages=251–5 |year=1996 |pmid=8998885|doi=10.1097/00003086-199604000-00031 |volume=325}}</ref> | ||
'''Medications''' | '''Medications''' | ||
* [[ACE inhibitor]]s have been proposed as a novel treatment of neurofibromas.<ref name=" pmid18157575">{{cite journal |author=Namazi H. |title=ACE inhibitors: a novel treatment for neurofibroma |journal=Clinical Orthopaedics and Related Research |volume=15 |issue=5 |pages=1538–9 |year=2008 |pmid=18157575|doi=10.1245/s10434-007-9737-5}}</ref> | * [[ACE inhibitor]]s have been proposed as a novel treatment of neurofibromas.<ref name=" pmid18157575">{{cite journal |author=Namazi H. |title=ACE inhibitors: a novel treatment for neurofibroma |journal=Clinical Orthopaedics and Related Research |volume=15 |issue=5 |pages=1538–9 |year=2008 |pmid=18157575|doi=10.1245/s10434-007-9737-5}}</ref> | ||
* ACE inhibitors are currently used to treat hypertension and congestive heart failure, to avert remodeling and reinfarction after myocardial infarction, and to ameliorate diabetic nephropathy and other renal diseases. | * ACE inhibitors are currently used to treat [[hypertension]] and [[congestive heart failure]], to avert remodeling and reinfarction after [[myocardial infarction]], and to ameliorate [[diabetic nephropathy]] and other renal diseases. | ||
* ACE inhibitors work by indirectly down regulating [[TGF beta|TGF-beta]], which is a growth factor that has been shown to influence the development of tumors.<ref name=" pmid18157575">{{cite journal |author=Namazi H. |title=ACE inhibitors: a novel treatment for neurofibroma |journal=Clinical Orthopaedics and Related Research |volume=15 |issue=5 |pages=1538–9 |year=2008 |pmid=18157575|doi=10.1245/s10434-007-9737-5}}</ref> | * ACE inhibitors work by indirectly down regulating [[TGF beta|TGF-beta]], which is a growth factor that has been shown to influence the development of [[tumors]].<ref name=" pmid18157575">{{cite journal |author=Namazi H. |title=ACE inhibitors: a novel treatment for neurofibroma |journal=Clinical Orthopaedics and Related Research |volume=15 |issue=5 |pages=1538–9 |year=2008 |pmid=18157575|doi=10.1245/s10434-007-9737-5}}</ref> | ||
==References== | ==References== | ||
Revision as of 14:29, 17 November 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2]
Overview
The predominant therapy for neurofibroma is surgical resection. Adjunctive chemotherapy and medications may be required.
Medical Therapy
Chemotherapy
- Once a plexiform neurofibroma has undergone malignant transformation, chemotherapy can be used as treatment.[1]
Radiation
- Radiation is generally not used as a treatment for plexiform neurofibromas because of concerns that this could actually promote malignant transformation. There has even been a documented case of a schwannoma being induced from a neurofibroma due to radiation therapy.[2]
Medications
- ACE inhibitors have been proposed as a novel treatment of neurofibromas.[3]
- ACE inhibitors are currently used to treat hypertension and congestive heart failure, to avert remodeling and reinfarction after myocardial infarction, and to ameliorate diabetic nephropathy and other renal diseases.
- ACE inhibitors work by indirectly down regulating TGF-beta, which is a growth factor that has been shown to influence the development of tumors.[3]
References
- ↑ Neurofibroma. Dr Bruno Di Muzio and Dr Maxime St-Amant et al. Radiopaedia.org 2015. http://radiopaedia.org/articles/neurofibroma
- ↑ Isler MH, Fogaça MF, Mankin HJ. (1996). "Radiation induced malignant schwannoma arising in a neurofibroma". Clinical Orthopaedics and Related Research. 325 (325): 251–5. doi:10.1097/00003086-199604000-00031. PMID 8998885.
- ↑ 3.0 3.1 Namazi H. (2008). "ACE inhibitors: a novel treatment for neurofibroma". Clinical Orthopaedics and Related Research. 15 (5): 1538–9. doi:10.1245/s10434-007-9737-5. PMID 18157575.