Nasopharyngeal carcinoma history and symptoms: Difference between revisions

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{{CMG}}
{{Nasopharyngeal carcinoma}}
{{Nasopharyngeal carcinoma}}
{{CMG}} {{AE}}{{Homa}}{{Faizan}}
==Overview==
==Overview==
Nasopharyngeal carcinoma produces few symptoms early in its course, with the result that most cases are quite advanced when detected. Once the tumor has expanded from its site of origin in the lateral wall of the nasopharynx, it may obstruct the nasal passages and cause [[rhinorrhea|nasal discharge]] or [[nosebleed]]. Obstruction of the [[Eustachian tube|auditory tubes]] may cause chronic [[otitis media|ear infection]]s, and patients may experience [[referred pain]] to the [[ear]]. [[Metastasis]] of cancer to the [[lymph node]]s of the [[neck]] may also be the first noticeable sign of the disease.<ref name="Weidner's">{{cite book |author=Richard Cote, Saul Suster, Lawrence Weiss, Noel Weidner (Editor) |title=Modern Surgical Pathology (2 Volume Set) |publisher=W B Saunders |location=London |year= |pages= |isbn=0-7216-7253-1 |oclc= |doi=}}</ref>
[[Symptoms]] of nasopharyngeal carcinoma based on the place of involvement are different. Most [[symptoms]] are related to existence of [[mass]] in nasopharynx, latero-posterior invasion of the [[tumor]] to the nasopharyngeal space and [[dysfunction]] of [[eustachian tube]], involvement of [[skull]] base accompanied by damaging of the 5th and 6th [[cranial nerves]], and [[Neck masses|neck mass]]. Most common [[symptoms]] are [[Neck masses|neck mass]], [[nasal]] [[symptoms]], [[ear]] [[symptoms]] and [[headache]].
==Symptoms==
* Abnormal (high-pitched) breathing sounds
* Cough
* Coughing up blood
* Difficulty swallowing
* Hoarseness that does not get better in 1 - 2 weeks
* Neck pain
* Sore throat that does not get better in 1 - 2 weeks, even with antibiotics
* Swelling or lumps in the neck
* Unintentional weight loss


==History and Symptoms==
*Most [[symptoms]] of nasopharyngeal carcinoma can be divided into four subtypes:<ref>{{Cite journal
| author = [[A. WM. Lee]], [[W. Foo]], [[S. CK. Law]], [[Y. F. Poon]], [[W. M. Sze]], [[S. K. O]], [[S. Y. Tung]] & [[W. H. Lau]]
| title = Nasopharyngeal carcinoma: presenting symptoms and duration before diagnosis
| journal = [[Hong Kong medical journal = Xianggang yi xue za zhi]]
| volume = 3
| issue = 4
| pages = 355–361
| year = 1997
| month = December
| pmid = 11847385
}}</ref><ref>{{Cite journal
| author = [[E. Ozyar]], [[I. L. Atahan]], [[F. H. Akyol]], [[M. Gurkaynak]] & [[A. F. Zorlu]]
| title = Cranial nerve involvement in nasopharyngeal carcinoma: its prognostic role and response to radiotherapy
| journal = [[Radiation medicine]]
| volume = 12
| issue = 2
| pages = 65–68
| year = 1994
| month = March-April
| pmid = 8079005
}}</ref><ref name="SkinnerVan Hasselt2016">{{cite journal|last1=Skinner|first1=Derek W.|last2=Van Hasselt|first2=C. Andrew|last3=Tsao|first3=S. Y.|title=Nasopharyngeal Carcinoma: Modes of Presentation|journal=Annals of Otology, Rhinology & Laryngology|volume=100|issue=7|year=2016|pages=544–551|issn=0003-4894|doi=10.1177/000348949110000705}}</ref><ref>{{Cite journal
| author = [[J. S. Sham]], [[Y. K. Cheung]], [[D. Choy]], [[F. L. Chan]] & [[L. Leong]]
| title = Cranial nerve involvement and base of the skull erosion in nasopharyngeal carcinoma
| journal = [[Cancer]]
| volume = 68
| issue = 2
| pages = 422–426
| year = 1991
| month = July
| pmid = 2070338
}}</ref>
*#Existence of [[mass]] in the nasopharynx:
*#*[[Epistaxis]]
*#*[[Nasal]] [[obstruction]]
*#*[[Nasal discharge]]
*#Latero-posterior invasion of the [[tumor]] to the nasopharyngeal space and [[dysfunction]] of [[eustachian tube]]:
*#*[[Tinnitus]]
*#*Hearing decrement
*#Involvement of [[skull]] base accompanied by damaging of the 5th and 6th [[cranial nerves]]:
*#*[[Headache]]
*#*[[Diplopia]]
*#*Facial [[pain]], and [[numbness]]
*#[[Neck masses|Neck mass]]
*
*
*
*
*
===Common Symptoms===
Common [[symptoms]] of nasopharyngeal disease include:
*[[Neck masses|Neck mass]]
*[[Nasal]] [[symptoms]]
*[[Ear]] [[symptoms]]
*[[Headache]]
===Less Common Symptoms===
Less common [[symptoms]] of nasopharyngeal disease include:
*[[Diplopia]]
*[[Facial]] [[numbness]]
*[[Weight loss]]
==References==
==References==
{{Reflist|2}}
{{Reflist|2}}
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{{WikiDoc Sources}}
{{WikiDoc Sources}}


[[Category:Disease]]
[[Category:Up-To-Date]]
[[Category:Types of cancer]]
[[Category:Medicine]]
[[Category:Oncology]]
[[Category:Otolaryngology]]

Latest revision as of 22:53, 29 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Homa Najafi, M.D.[2]Faizan Sheraz, M.D. [3]

Overview

Symptoms of nasopharyngeal carcinoma based on the place of involvement are different. Most symptoms are related to existence of mass in nasopharynx, latero-posterior invasion of the tumor to the nasopharyngeal space and dysfunction of eustachian tube, involvement of skull base accompanied by damaging of the 5th and 6th cranial nerves, and neck mass. Most common symptoms are neck mass, nasal symptoms, ear symptoms and headache.

History and Symptoms

Common Symptoms

Common symptoms of nasopharyngeal disease include:

Less Common Symptoms

Less common symptoms of nasopharyngeal disease include:

References

  1. A. WM. Lee, W. Foo, S. CK. Law, Y. F. Poon, W. M. Sze, S. K. O, S. Y. Tung & W. H. Lau (1997). "Nasopharyngeal carcinoma: presenting symptoms and duration before diagnosis". Hong Kong medical journal = Xianggang yi xue za zhi. 3 (4): 355–361. PMID 11847385. Unknown parameter |month= ignored (help)
  2. E. Ozyar, I. L. Atahan, F. H. Akyol, M. Gurkaynak & A. F. Zorlu (1994). "Cranial nerve involvement in nasopharyngeal carcinoma: its prognostic role and response to radiotherapy". Radiation medicine. 12 (2): 65–68. PMID 8079005. Unknown parameter |month= ignored (help)
  3. Skinner, Derek W.; Van Hasselt, C. Andrew; Tsao, S. Y. (2016). "Nasopharyngeal Carcinoma: Modes of Presentation". Annals of Otology, Rhinology & Laryngology. 100 (7): 544–551. doi:10.1177/000348949110000705. ISSN 0003-4894.
  4. J. S. Sham, Y. K. Cheung, D. Choy, F. L. Chan & L. Leong (1991). "Cranial nerve involvement and base of the skull erosion in nasopharyngeal carcinoma". Cancer. 68 (2): 422–426. PMID 2070338. Unknown parameter |month= ignored (help)


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