Nasopharyngeal carcinoma classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Homa Najafi, M.D.[2]Faizan Sheraz, M.D. [3]

Overview

Nasopharyngeal carcinoma may be classified according to microscopic features into 3 subtypes: keratinizing squamous cell carcinoma, nonkeratinizing carcinoma, and undifferentiated type.

Classification

Histologic classification

World Health Classification (2005) for NPC:<ref name= Librepathology>Nasopharyngeal carcinoma

Type Histology Description EBV Prevalence Prognosis
1 Keratinizing SCC graded poorly-well-differentiated -ve bad
2a Nonkeratinizing carcinoma, differentiated well defined cell borders & tumor nest borders +ve good
2b Nonkeratinizing carcinoma, undifferentiated sheets/syncytial, vescicular nuclei, prominent nucleoli, pink cytoplasm most common
3 Basaloid SCC mimics basal cell carcinoma least common

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