Nasopharyngeal carcinoma classification: Difference between revisions

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==Classification==
==Classification==
===Histologic classification===
World Health Classification (2005) for NPC:{{cite book | last = Barnes | first = Leon | title = Pathology and genetics of head and neck tumours | publisher = IARC Press | location = Lyon | year = 2005 | isbn = 978-92-832-2417-4 }} 
World Health Classification (2005) for NPC  
{| class="wikitable"
{| class="wikitable"
! Classification
! Classification
! Former name
! Former name
! Description
! EBV
! EBV
! Prevalence
! Prevalence
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|-
|-
| Keratinizing  
| Keratinizing  
|Type 1, squamous cell
|Type 1, squamous cell carcinoma
 
carcinoma
| graded poorly-well-differentiated
| -ve
| -ve
|
|almost 1/4 of NPC cases
| poor
| poor
|-
|-
| Nonkeratinizing, differentiated
| Nonkeratinizing, differentiated
|Type 2, transitional
|Type 2, transitional carcinoma
 
carcinoma
| well defined cell borders & tumor nest borders
| +ve
| +ve
|
|less than 1/6 of NPC cases
| good
| good
|-
|-
| Nonkeratinizing, undifferentiated
| Nonkeratinizing, undifferentiated
|Type 3,
|Type 3, lymphoepithelial carcinoma
 
lymphoepithelial
 
carcinoma
| sheets/syncytial, vescicular nuclei, prominent nucleoli, pink cytoplasm
|<nowiki>+ve</nowiki>
|<nowiki>+ve</nowiki>
| most common
| most common
|
|good
|-
|-
| Basaloid squamous cell carcinoma (BSCC)
| Basaloid squamous cell carcinoma (BSCC)
|  
|  
| mimics basal cell carcinoma
|
|
| least common
| least common
|
|poor
|}
|}



Revision as of 16:44, 19 February 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Homa Najafi, M.D.[2]Faizan Sheraz, M.D. [3]

Overview

Nasopharyngeal carcinoma may be classified according to microscopic features into 3 subtypes: keratinizing squamous cell carcinoma, nonkeratinizing carcinoma, and undifferentiated type.

Classification

World Health Classification (2005) for NPC:Barnes, Leon (2005). Pathology and genetics of head and neck tumours. Lyon: IARC Press. ISBN 978-92-832-2417-4.

Classification Former name EBV Prevalence Prognosis
Keratinizing Type 1, squamous cell carcinoma -ve almost 1/4 of NPC cases poor
Nonkeratinizing, differentiated Type 2, transitional carcinoma +ve less than 1/6 of NPC cases good
Nonkeratinizing, undifferentiated Type 3, lymphoepithelial carcinoma +ve most common good
Basaloid squamous cell carcinoma (BSCC) least common poor

References


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