Nasopharyngeal carcinoma classification: Difference between revisions

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Revision as of 14:38, 24 September 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Faizan Sheraz, M.D. [2]

Overview

Nasopharyngeal carcinoma may be classified according to microscopic features into 3 subtypes: well-differentiated, moderately-differentiated, and undifferentiated type.

Classification

Histologic classification

World Health Classification (2005) for NPC:^[1]

Type	Histology	Description	EBV	Prevalence	Prognosis
1	Keratinizing SCC	graded poorly-well-differentiated	-ve		bad
2a	Nonkeratinizing carcinoma, differentiated	well defined cell borders & tumor nest borders	+ve		good
2b	Nonkeratinizing carcinoma, undifferentiated	sheets/syncytial, vescicular nuclei, prominent nucleoli, pink cytoplasm		most common
3	Basaloid SCC	mimics basal cell carcinoma		least common

References

↑ Nasopharyngeal carcinoma http://librepathology.org/wiki/index.php/Nasopharyngeal_carcinoma

Template:WikiDoc Sources

[Librepathology-1] Nasopharyngeal carcinoma http://librepathology.org/wiki/index.php/Nasopharyngeal_carcinoma

[1]

@@ Line 5: / Line 5: @@
 ==Classification==
-[[Nasopharyngeal carcinoma]] may be classified according to [[microscopic]] features into 3 subtypes:<ref name="Weidner's">{{cite book |author=Richard Cote, Saul Suster, Lawrence Weiss, Noel Weidner (Editor) |title=Modern Surgical Pathology (2 Volume Set) |publisher=W B Saunders |location=London |year= |pages= |isbn=0-7216-7253-1 |oclc= |doi=}}</ref>
+===Histologic classification===
-*Well-differentiated ([[keratin]]izing type)
-*Moderately-differentiated (nonkeratinizing type)
-*Undifferentiated (most strongly associated with [[Epstein-Barr virus]] infection)
-<gallery>Image:Lymphoepithelioma met to LN 4.jpg|Undifferentiated nasopharyngeal carcinoma - low power
-Image:Lymphoepithelioma met to LN 1.jpg|Undifferentiated nasopharyngeal carcinoma - med. power
-Image:Lymphoepithelioma met to LN 2.jpg|Undifferentiated nasopharyngeal carcinoma - high power
-</gallery>
-===Histologic subclassification===
 World Health Classification (2005) for NPC:<ref name= Librepathology>Nasopharyngeal carcinoma http://librepathology.org/wiki/index.php/Nasopharyngeal_carcinoma</ref>
 {| class="wikitable"