Difference between revisions of "Narcolepsy historical perspective"

Jump to: navigation, search
(Landmark Events in the Development of Treatment Strategies)
(Landmark Events in the Development of Treatment Strategies)
(One intermediate revision by the same user not shown)
Line 24: Line 24:
===Landmark Events in the Development of Treatment Strategies===
===Landmark Events in the Development of Treatment Strategies===
* Various methods were initially proposed in the [[treatment]] of narcolepsy until Prinzmetal and Bloomberg introduced [[amphetamines]] in 1935.
* Various methods were initially proposed in the [[treatment]] of narcolepsy until Prinzmetal and Bloomberg introduced [[amphetamines]] in 1935.<ref name="Prinzmetal1935">{{cite journal|last1=Prinzmetal|first1=Myron|title=THE USE OF BENZEDRINE FOR THE TREATMENT OF NARCOLEPSY|journal=Journal of the American Medical Association|volume=105|issue=25|year=1935|pages=2051|issn=0002-9955|doi=10.1001/jama.1935.02760510023006}}</ref>
* After the discovery of [[tricyclic antidepressants]] in 1957, Akimoto, Honda, and Takahashi used [[imipramine]] in the [[treatment]] of [[cataplexy]] in [[humans]].
* After the discovery of [[tricyclic antidepressants]] in 1957, Akimoto, Honda, and Takahashi used [[imipramine]] in the [[treatment]] of [[cataplexy]] in [[humans]].
* [[Methylphenidate]] was introduced by Yoss and Daly in the 1960s.
* [[Methylphenidate]] was introduced by Yoss and Daly in the 1960s.<ref name="YossDaly1959">{{cite journal|last1=Yoss|first1=R. E.|last2=Daly|first2=D.|title=Treatment of narcolepsy with Ritalin|journal=Neurology|volume=9|issue=3|year=1959|pages=171–171|issn=0028-3878|doi=10.1212/WNL.9.3.171}}</ref>
===Impact on Cultural History===
===Impact on Cultural History===

Revision as of 18:13, 2 August 2020

Narcolepsy Microchapters


Patient Information


Historical Perspective




Differentiating Narcolepsy from other Diseases

Epidemiology and Demographics

Risk Factors


Natural History, Complications and Prognosis


Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings



Echocardiography and Ultrasound

CT scan


Other Imaging Findings

Other Diagnostic Studies


Medical Therapy



Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Narcolepsy historical perspective On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides


American Roentgen Ray Society Images of Narcolepsy historical perspective

All Images
Echo & Ultrasound
CT Images

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Narcolepsy historical perspective

CDC on Narcolepsy historical perspective

Narcolepsy historical perspective in the news

Blogs on Narcolepsy historical perspective

Directions to Hospitals Treating Psoriasis

Risk calculators and risk factors for Narcolepsy historical perspective

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Muhammad Waleed Haider, M.D.[2]


Historical Perspective


  • Cataplexy from the Greek kataplexis (fixation of the eyes), was first named by Loëwenfeld (1902) as he was the first to name brief episodes of muscle weakness triggered by emotions.[7]
  • Kinnier Wilson (1928) first coined the term, "sleep paralysis."
  • Large case series of narcolepsy with cataplexy was published by Addie (1926), Wilson (1927), and Daniels (1934).[8][9][10] Review of narcolepsy-cataplexy by Daniels is considered by many as one of the most insightful clinical reviews published.
  • The association of oculomotor paralysis and somnolence led to the pioneering work of Von Economo (1930) who first recognized the posterior hypothalamus as a critical region for the promotion of wakefulness and correctly proposed that a region in the posterior hypothalamus was lesioned in human narcolepsy.[11] He specifically wrote: “it is very probable, though not proved, that the narcolepsy of Redlich, Westphal, and Gélineau has its primary cause in a yet unknown disease of that region”.
  • The classic description of narcolepsy tetrad was possible due to further work by Yoss and Daly at the Mayo clinic in 1957 and Bedrich Roth in Prague.[12][13]
  • REM sleep at the onset of sleep attack in narcoleptic patients was first ever recorded and reported by Vogel (1960), an observation extended by Rechschaffen and Dement in 1967.
  • In [year], [scientist] was the first to discover the association between [risk factor] and the development of [disease name].
  • In [year], [gene] mutations were first implicated in the pathogenesis of [disease name].

Landmark Events in the Development of Treatment Strategies

Impact on Cultural History

Famous Cases

The following are a few famous cases of [disease name]:


  1. Fischer, Franz (1878). "Epileptoide Schlafzustände". Archiv für Psychiatrie und Nervenkrankheiten. 8 (1): 200–203. doi:10.1007/BF01791317. ISSN 0003-9373.
  2. Westphal C. Eigenthümliche mit Einschläfen verbundene Anfälle. Arch. Psychiat., 7: 631-635 1877.
  3. Schenck CH, Bassetti CL, Arnulf I, Mignot E (2007). "English translations of the first clinical reports on narcolepsy and cataplexy by Westphal and Gélineau in the late 19th century, with commentary". J Clin Sleep Med. 3 (3): 301–11. PMC 2564780. PMID 17561602.
  4. Janković S, Susić V, Sokić D, Lević Z (1996). "[Dr. John Baptiste Edouard Gélineau]". Srp Arh Celok Lek. 124 (11–12): 331–5. PMID 9132972.
  5. Gélineau J. De la narcolepsie. Gazette des hôpitaux,. 53: 626-628, 1880.
  6. Gélineau JBE. De la narcolepsie. Surgères, Charente-Inférieure: Imprimerie de Surgères, 64, 1881.
  7. Löwenfeld L. Uber Narkolepsie. Munch. Med. Wochenschr., 49: 1041-1045, 1902.
  8. Addie W. IdIopathic narcolepsy: a disease sui generis; with remarks on the mechanism of sleep. Brain, 49: 257-306, 1926.
  9. Wilson SAK. The narcolepsies. Annual Congress Assoc. Phys., June 3: 63-109, 1927.
  10. Daniels LE. Narcolepsy. Medicine, 13(1): 1-122, 1934.
  11. Van Economo C. Sleep as a problem of localization. J. Nerv. Ment. Disease, 71(3): 249-259, 1930.
  12. . doi:10.1159/isbn.978-3-318-05312-8. Missing or empty |title= (help)
  13. YOSS RE, DALY DD (1957). "Criteria for the diagnosis of the narcoleptic syndrome". Proc Staff Meet Mayo Clin. 32 (12): 320–8. PMID 13441766.
  14. Prinzmetal, Myron (1935). "THE USE OF BENZEDRINE FOR THE TREATMENT OF NARCOLEPSY". Journal of the American Medical Association. 105 (25): 2051. doi:10.1001/jama.1935.02760510023006. ISSN 0002-9955.
  15. Yoss, R. E.; Daly, D. (1959). "Treatment of narcolepsy with Ritalin". Neurology. 9 (3): 171–171. doi:10.1212/WNL.9.3.171. ISSN 0028-3878.