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* Various methods were initially proposed in the [[treatment]] of narcolepsy until Prinzmetal and Bloomberg introduced [[amphetamines]] in 1935. | * Various methods were initially proposed in the [[treatment]] of narcolepsy until Prinzmetal and Bloomberg introduced [[amphetamines]] in 1935. | ||
* After the discovery of [[tricyclic antidepressants]] in 1957, Akimoto, Honda, and Takahashi used [[imipramine]] in the [[treatment]] of [[ | * After the discovery of [[tricyclic antidepressants]] in 1957, Akimoto, Honda, and Takahashi used [[imipramine]] in the [[treatment]] of [[cataplexy]] in [[humans]]. | ||
* [[Methylphenidate]] was introduced by Yoss and Daly in the 1960s. | * [[Methylphenidate]] was introduced by Yoss and Daly in the 1960s. | ||
Revision as of 18:09, 2 August 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Muhammad Waleed Haider, M.D.[2]
Overview
Historical Perspective
Discovery
- The earliest account of narcolepsy was described by Thomas Willis (1621-1675) in patients, "with a sleepy disposition who suddenly falls fast asleep."
- The term narcolepsy is derived by combining the Greek narke numbness, stupor and lepsis attack, to seize.
- The first-ever convincing descriptions of narcolepsy and cataplexy were reported by Westphal (1877) and Fisher (1878) in Germany.[1][2] Both descriptions observed a hereditary factor in narcolepsy; the mother of Westphal's patient and a sister of Fisher's patient had similar clinical features. They also reported the unique association of excitement and sleepiness triggering episodes of muscle weakness.
- French physician Jean-Baptiste-Édouard Gélineau (1880) described this condition in a wine merchant as neurosis or a functional condition.[3] He gave narcolepsy its name, which is the English form of the French word narcolepsie, and also recognized this disorder as a specific clinical entity.[4][5][6] Although Gélineau named this distinct clinical entity he did not differentiate episodes of muscle weakness and sleep attacks triggered by emotions as he proposed common physiology for these two distinct symptoms of narcolepsy.
- Cataplexy from the Greek kataplexis (fixation of the eyes), was first named by Loëwenfeld (1902) as he was the first to name brief episodes of muscle weakness triggered by emotions.[7]
- Kinnier Wilson (1928) first coined the term, "sleep paralysis."
- Large case series of narcolepsy with cataplexy was published by Addie (1926), Wilson (1927), and Daniels (1934).[8][9][10] Review of narcolepsy-cataplexy by Daniels is considered by many as one of the most insightful clinical reviews published.
- The association of oculomotor paralysis and somnolence led to the pioneering work of Von Economo (1930) who first recognized the posterior hypothalamus as a critical region for the promotion of wakefulness and correctly proposed that a region in the posterior hypothalamus was lesioned in human narcolepsy.[11] He specifically wrote: “it is very probable, though not proved, that the narcolepsy of Redlich, Westphal, and Gélineau has its primary cause in a yet unknown disease of that region”.
- The classic description of narcolepsy tetrad was possible due to further work by Yoss and Daly at the Mayo clinic in 1957 and Bedrich Roth in Prague.[12][13]
- REM sleep at the onset of sleep attack in narcoleptic patients was first ever recorded and reported by Vogel (1960), an observation extended by Rechschaffen and Dement in 1967.
- In [year], [scientist] was the first to discover the association between [risk factor] and the development of [disease name].
- In [year], [gene] mutations were first implicated in the pathogenesis of [disease name].
Landmark Events in the Development of Treatment Strategies
- Various methods were initially proposed in the treatment of narcolepsy until Prinzmetal and Bloomberg introduced amphetamines in 1935.
- After the discovery of tricyclic antidepressants in 1957, Akimoto, Honda, and Takahashi used imipramine in the treatment of cataplexy in humans.
- Methylphenidate was introduced by Yoss and Daly in the 1960s.
Impact on Cultural History
Famous Cases
The following are a few famous cases of [disease name]:
References
- ↑ Fischer, Franz (1878). "Epileptoide Schlafzustände". Archiv für Psychiatrie und Nervenkrankheiten. 8 (1): 200–203. doi:10.1007/BF01791317. ISSN 0003-9373.
- ↑ Westphal C. Eigenthümliche mit Einschläfen verbundene Anfälle. Arch. Psychiat., 7: 631-635 1877.
- ↑ Schenck CH, Bassetti CL, Arnulf I, Mignot E (2007). "English translations of the first clinical reports on narcolepsy and cataplexy by Westphal and Gélineau in the late 19th century, with commentary". J Clin Sleep Med. 3 (3): 301–11. PMC 2564780. PMID 17561602.
- ↑ Janković S, Susić V, Sokić D, Lević Z (1996). "[Dr. John Baptiste Edouard Gélineau]". Srp Arh Celok Lek. 124 (11–12): 331–5. PMID 9132972.
- ↑ Gélineau J. De la narcolepsie. Gazette des hôpitaux,. 53: 626-628, 1880.
- ↑ Gélineau JBE. De la narcolepsie. Surgères, Charente-Inférieure: Imprimerie de Surgères, 64, 1881.
- ↑ Löwenfeld L. Uber Narkolepsie. Munch. Med. Wochenschr., 49: 1041-1045, 1902.
- ↑ Addie W. IdIopathic narcolepsy: a disease sui generis; with remarks on the mechanism of sleep. Brain, 49: 257-306, 1926.
- ↑ Wilson SAK. The narcolepsies. Annual Congress Assoc. Phys., June 3: 63-109, 1927.
- ↑ Daniels LE. Narcolepsy. Medicine, 13(1): 1-122, 1934.
- ↑ Van Economo C. Sleep as a problem of localization. J. Nerv. Ment. Disease, 71(3): 249-259, 1930.
- ↑ . doi:10.1159/isbn.978-3-318-05312-8. Missing or empty
|title=(help) - ↑ YOSS RE, DALY DD (1957). "Criteria for the diagnosis of the narcoleptic syndrome". Proc Staff Meet Mayo Clin. 32 (12): 320–8. PMID 13441766.