Naphthylisopropylamine

Naphthylisopropylamine
	File:Naphthylisopropylamine.png
Identifiers
	IUPAC name 2-(2-aminopropyl)naphthalene;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C13H15N
Molar mass	185.27 g/mol

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Naphthylisopropylamine (PAL-287) is a stimulant drug developed for the treatment of amphetamine and cocaine addiction. PAL-287 acts by releasing dopamine and serotonin.^[1]

In animal studies, PAL-287 was shown to reduce cocaine self-administration, yet produced relatively little stimulant effect when administered by itself, being a weaker stimulant than the comparison drug dexamphetamine.^[2] PAL-287 is now under development to see whether it is a useful substitute drug for treating stimulant addiction in humans.

References

↑ Rothman RB, Blough BE, Baumann MH. Dual dopamine/serotonin releasers as potential medications for stimulant and alcohol addictions. AAPS J. 2007 Jan 5;9(1):E1-10.
↑ Richard B. Rothman, Bruce E. Blough, William L. Woolverton, Karen G. Anderson, S. Stevens Negus, Nancy K. Mello, Bryan L. Roth, and Michael H. Baumann. Development of a Rationally Designed, Low Abuse Potential, Biogenic Amine Releaser That Suppresses Cocaine Self-Administration. Journal of Pharmacology And Experimental Therapeutics. 2005; 313: 1361-1369.

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[1] Rothman RB, Blough BE, Baumann MH. Dual dopamine/serotonin releasers as potential medications for stimulant and alcohol addictions. AAPS J. 2007 Jan 5;9(1):E1-10.

[2] Richard B. Rothman, Bruce E. Blough, William L. Woolverton, Karen G. Anderson, S. Stevens Negus, Nancy K. Mello, Bryan L. Roth, and Michael H. Baumann. Development of a Rationally Designed, Low Abuse Potential, Biogenic Amine Releaser That Suppresses Cocaine Self-Administration. Journal of Pharmacology And Experimental Therapeutics. 2005; 313: 1361-1369.

[1]

[2]

Identifiers
File:Naphthylisopropylamine.png
IUPAC name 2-(2-aminopropyl)naphthalene
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C₁₃H₁₅N
Molar mass	185.27 g/mol

Naphthylisopropylamine

References

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