NXT1

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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NTF2-related export protein 1 is a protein that in humans is encoded by the NXT1 gene.[1][2][3]

The protein encoded by this gene is located in the nuclear envelope. It has protein similarity to nuclear transport factor 2. This protein functions as a nuclear export factor in both RAN (Ras-related nuclear protein)- and CRM1 (required for chromosome region maintenance)-dependent pathways. It is found to stimulate the export of U1 snRNA in RAN- and CRM1-dependent pathways and the export of tRNA and mRNA in a CRM1-independent pathway. The encoded protein heterodimerizes with Tap protein and may regulate the ability of Tap protein to mediate nuclear mRNA export. The use of alternate polyadenylation sites has been found for this gene.[3]

References

  1. Black BE, Levesque L, Holaska JM, Wood TC, Paschal BM (Jan 2000). "Identification of an NTF2-related factor that binds Ran-GTP and regulates nuclear protein export". Mol Cell Biol. 19 (12): 8616–24. PMC 84993. PMID 10567585.
  2. Guzik BW, Levesque L, Prasad S, Bor YC, Black BE, Paschal BM, Rekosh D, Hammarskjold ML (Mar 2001). "NXT1 (p15) is a crucial cellular cofactor in TAP-dependent export of intron-containing RNA in mammalian cells". Mol Cell Biol. 21 (7): 2545–54. doi:10.1128/MCB.21.7.2545-2554.2001. PMC 86886. PMID 11259602.
  3. 3.0 3.1 "Entrez Gene: NXT1 NTF2-like export factor 1".

Further reading