NTRK2

Neurotrophic tyrosine kinase, receptor, type 2
File:PBB Protein NTRK2 image.jpg PDB rendering based on 1hcf.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1hcf​, 1wwb​
Identifiers
Symbols	NTRK2 ; GP145-TrkB; TRKB
External IDs	Template:OMIM5 Template:MGI HomoloGene: 4504
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE NTRK2 207152 at tn.png
File:PBB GE NTRK2 214680 at tn.png
File:PBB GE NTRK2 221795 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Neurotrophic tyrosine kinase, receptor, type 2, also known as NTRK2, is a human gene.

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for this gene.

Further reading

• Yamada K, Nabeshima T (2004). "Brain-derived neurotrophic factor/TrkB signaling in memory processes". J. Pharmacol. Sci. 91 (4): 267–70. PMID 12719654.
• Soppet D, Escandon E, Maragos J; et al. (1991). "The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor". Cell. 65 (5): 895–903. PMID 1645620.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Squinto SP, Stitt TN, Aldrich TH; et al. (1991). "trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor". Cell. 65 (5): 885–93. PMID 1710174.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Haniu M, Talvenheimo J, Le J; et al. (1995). "Extracellular domain of neurotrophin receptor trkB: disulfide structure, N-glycosylation sites, and ligand binding". Arch. Biochem. Biophys. 322 (1): 256–64. doi:10.1006/abbi.1995.1460. PMID 7574684.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ip NY, Stitt TN, Tapley P; et al. (1993). "Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells". Neuron. 10 (2): 137–49. PMID 7679912.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Slaugenhaupt SA, Blumenfeld A, Liebert CB; et al. (1995). "The human gene for neurotrophic tyrosine kinase receptor type 2 (NTRK2) is located on chromosome 9 but is not the familial dysautonomia gene". Genomics. 25 (3): 730–2. PMID 7759111.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nakagawara A, Liu XG, Ikegaki N; et al. (1995). "Cloning and chromosomal localization of the human TRK-B tyrosine kinase receptor gene (NTRK2)". Genomics. 25 (2): 538–46. PMID 7789988.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shelton DL, Sutherland J, Gripp J; et al. (1995). "Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins". J. Neurosci. 15 (1 Pt 2): 477–91. PMID 7823156.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Allen SJ, Dawbarn D, Eckford SD; et al. (1994). "Cloning of a non-catalytic form of human trkB and distribution of messenger RNA for trkB in human brain". Neuroscience. 60 (3): 825–34. PMID 7936202.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rydén M, Ibáñez CF (1996). "Binding of neurotrophin-3 to p75LNGFR, TrkA, and TrkB mediated by a single functional epitope distinct from that recognized by trkC". J. Biol. Chem. 271 (10): 5623–7. PMID 8621424.
• Yamamoto M, Sobue G, Yamamoto K; et al. (1997). "Expression of mRNAs for neurotrophic factors (NGF, BDNF, NT-3, and GDNF) and their receptors (p75NGFR, trkA, trkB, and trkC) in the adult human peripheral nervous system and nonneural tissues". Neurochem. Res. 21 (8): 929–38. PMID 8895847.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Valent A, Danglot G, Bernheim A (1997). "Mapping of the tyrosine kinase receptors trkA (NTRK1), trkB (NTRK2) and trkC(NTRK3) to human chromosomes 1q22, 9q22 and 15q25 by fluorescence in situ hybridization". Eur. J. Hum. Genet. 5 (2): 102–4. PMID 9195161.CS1 maint: Multiple names: authors list (link)
• Haniu M, Montestruque S, Bures EJ; et al. (1997). "Interactions between brain-derived neurotrophic factor and the TRKB receptor. Identification of two ligand binding domains in soluble TRKB by affinity separation and chemical cross-linking". J. Biol. Chem. 272 (40): 25296–303. PMID 9312147.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nakamura T, Muraoka S, Sanokawa R, Mori N (1998). "N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling". J. Biol. Chem. 273 (12): 6960–7. PMID 9507002.CS1 maint: Multiple names: authors list (link)
• Hackett SF, Friedman Z, Freund J; et al. (1998). "A splice variant of trkB and brain-derived neurotrophic factor are co-expressed in retinal pigmented epithelial cells and promote differentiated characteristics". Brain Res. 789 (2): 201–12. PMID 9573364.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Iwasaki Y, Gay B, Wada K, Koizumi S (1998). "Association of the Src family tyrosine kinase Fyn with TrkB". J. Neurochem. 71 (1): 106–11. PMID 9648856.CS1 maint: Multiple names: authors list (link)
• Qian X, Riccio A, Zhang Y, Ginty DD (1999). "Identification and characterization of novel substrates of Trk receptors in developing neurons". Neuron. 21 (5): 1017–29. PMID 9856458.CS1 maint: Multiple names: authors list (link)
• Bibel M, Hoppe E, Barde YA (1999). "Biochemical and functional interactions between the neurotrophin receptors trk and p75NTR". EMBO J. 18 (3): 616–22. doi:10.1093/emboj/18.3.616. PMID 9927421.CS1 maint: Multiple names: authors list (link)
• Yamada M, Ohnishi H, Sano S; et al. (1999). "Brain-derived neurotrophic factor stimulates interactions of Shp2 with phosphatidylinositol 3-kinase and Grb2 in cultured cerebral cortical neurons". J. Neurochem. 73 (1): 41–9. PMID 10386953.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ultsch MH, Wiesmann C, Simmons LC; et al. (1999). "Crystal structures of the neurotrophin-binding domain of TrkA, TrkB and TrkC". J. Mol. Biol. 290 (1): 149–59. doi:10.1006/jmbi.1999.2816. PMID 10388563.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)