NTHL1

Nth endonuclease III-like 1 (E. coli)
Identifiers
Symbols	NTHL1 ; NTH1; OCTS3
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1897
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE NTHL1 209731 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Nth endonuclease III-like 1 (E. coli), also known as NTHL1, is a human gene.

Further reading

• Hilbert TP, Boorstein RJ, Kung HC; et al. (1996). "Purification of a mammalian homologue of Escherichia coli endonuclease III: identification of a bovine pyrimidine hydrate-thymine glycol DNAse/AP lyase by irreversible cross linking to a thymine glycol-containing oligoxynucleotide". Biochemistry. 35 (8): 2505–11. doi:10.1021/bi952516e. PMID 8611553.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Aspinwall R, Rothwell DG, Roldan-Arjona T; et al. (1997). "Cloning and characterization of a functional human homolog of Escherichia coli endonuclease III". Proc. Natl. Acad. Sci. U.S.A. 94 (1): 109–14. PMID 8990169.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hilbert TP, Chaung W, Boorstein RJ; et al. (1997). "Cloning and expression of the cDNA encoding the human homologue of the DNA repair enzyme, Escherichia coli endonuclease III". J. Biol. Chem. 272 (10): 6733–40. PMID 9045706.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ikeda S, Biswas T, Roy R; et al. (1998). "Purification and characterization of human NTH1, a homolog of Escherichia coli endonuclease III. Direct identification of Lys-212 as the active nucleophilic residue". J. Biol. Chem. 273 (34): 21585–93. PMID 9705289.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sarker AH, Ikeda S, Nakano H; et al. (1999). "Cloning and characterization of a mouse homologue (mNthl1) of Escherichia coli endonuclease III". J. Mol. Biol. 282 (4): 761–74. doi:10.1006/jmbi.1998.2042. PMID 9743625.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Imai K, Sarker AH, Akiyama K; et al. (1999). "Genomic structure and sequence of a human homologue (NTHL1/NTH1) of Escherichia coli endonuclease III with those of the adjacent parts of TSC2 and SLC9A3R2 genes". Gene. 222 (2): 287–95. PMID 9831664.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bessho T (1999). "Nucleotide excision repair 3' endonuclease XPG stimulates the activity of base excision repairenzyme thymine glycol DNA glycosylase". Nucleic Acids Res. 27 (4): 979–83. PMID 9927729.
• Luna L, Bjørås M, Hoff E; et al. (2000). "Cell-cycle regulation, intracellular sorting and induced overexpression of the human NTH1 DNA glycosylase involved in removal of formamidopyrimidine residues from DNA". Mutat. Res. 460 (2): 95–104. PMID 10882850.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Matsumoto Y, Zhang QM, Takao M; et al. (2002). "Escherichia coli Nth and human hNTH1 DNA glycosylases are involved in removal of 8-oxoguanine from 8-oxoguanine/guanine mispairs in DNA". Nucleic Acids Res. 29 (9): 1975–81. PMID 11328882.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Miyabe I, Zhang QM, Kino K; et al. (2002). "Identification of 5-formyluracil DNA glycosylase activity of human hNTH1 protein". Nucleic Acids Res. 30 (15): 3443–8. PMID 12140329.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu X, Roy R (2002). "Truncation of amino-terminal tail stimulates activity of human endonuclease III (hNTH1)". J. Mol. Biol. 321 (2): 265–76. PMID 12144783.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Marenstein DR, Chan MK, Altamirano A; et al. (2003). "Substrate specificity of human endonuclease III (hNTH1). Effect of human APE1 on hNTH1 activity". J. Biol. Chem. 278 (11): 9005–12. doi:10.1074/jbc.M212168200. PMID 12519758.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ikeda S, Kohmoto T, Tabata R, Seki Y (2003). "Differential intracellular localization of the human and mouse endonuclease III homologs and analysis of the sorting signals". DNA Repair (Amst.). 1 (10): 847–54. PMID 12531031.CS1 maint: Multiple names: authors list (link)
• Liu X, Choudhury S, Roy R (2004). "In vitro and in vivo dimerization of human endonuclease III stimulates its activity". J. Biol. Chem. 278 (50): 50061–9. doi:10.1074/jbc.M309997200. PMID 14522981.CS1 maint: Multiple names: authors list (link)
• Katafuchi A, Nakano T, Masaoka A; et al. (2004). "Differential specificity of human and Escherichia coli endonuclease III and VIII homologues for oxidative base lesions". J. Biol. Chem. 279 (14): 14464–71. doi:10.1074/jbc.M400393200. PMID 14734554.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wiederhold L, Leppard JB, Kedar P; et al. (2004). "AP endonuclease-independent DNA base excision repair in human cells". Mol. Cell. 15 (2): 209–20. doi:10.1016/j.molcel.2004.06.003. PMID 15260972.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Oyama M, Wakasugi M, Hama T; et al. (2004). "Human NTH1 physically interacts with p53 and proliferating cell nuclear antigen". Biochem. Biophys. Res. Commun. 321 (1): 183–91. doi:10.1016/j.bbrc.2004.06.136. PMID 15358233.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang QM, Yonekura S, Takao M; et al. (2005). "DNA glycosylase activities for thymine residues oxidized in the methyl group are functions of the hNEIL1 and hNTH1 enzymes in human cells". DNA Repair (Amst.). 4 (1): 71–9. doi:10.1016/j.dnarep.2004.08.002. PMID 15533839.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)