NDEL1
| NudE nuclear distribution gene E homolog (A. nidulans)-like 1 | |||||||||||
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| Identifiers | |||||||||||
| Symbols | NDEL1 ; DKFZp451M0318; EOPA; MITAP1; NUDEL | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 32567 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE NDEL1 208093 s at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
NudE nuclear distribution gene E homolog (A. nidulans)-like 1, also known as NDEL1, is a human gene.[1]
This gene encodes a thiol-activated peptidase that is phosphorylated in M phase of the cell cycle. Phosphorylation regulates the cell cycle-dependent distribution of this protein, with a fraction of the protein bound strongly to centrosomes in interphase and localized to mitotic spindles in early M phase. Overall, this protein plays a role in nervous system development. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[1]
References
Further reading
- Andersson B, Wentland MA, Ricafrente JY; et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
- Yu W, Andersson B, Worley KC; et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. PMID 9110174.
- Dias Neto E, Correa RG, Verjovski-Almeida S; et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. PMID 10737800.
- Feng Y, Olson EC, Stukenberg PT; et al. (2001). "LIS1 regulates CNS lamination by interacting with mNudE, a central component of the centrosome". Neuron. 28 (3): 665–79. PMID 11163258.
- Sasaki S, Shionoya A, Ishida M; et al. (2001). "A LIS1/NUDEL/cytoplasmic dynein heavy chain complex in the developing and adult nervous system". Neuron. 28 (3): 681–96. PMID 11163259.
- Niethammer M, Smith DS, Ayala R; et al. (2001). "NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein". Neuron. 28 (3): 697–711. PMID 11163260.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Ozeki Y, Tomoda T, Kleiderlein J; et al. (2003). "Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth". Proc. Natl. Acad. Sci. U.S.A. 100 (1): 289–94. doi:10.1073/pnas.0136913100. PMID 12506198.
- Yan X, Li F, Liang Y; et al. (2003). "Human Nudel and NudE as regulators of cytoplasmic dynein in poleward protein transport along the mitotic spindle". Mol. Cell. Biol. 23 (4): 1239–50. PMID 12556484.
- Cardoso C, Leventer RJ, Ward HL; et al. (2003). "Refinement of a 400-kb critical region allows genotypic differentiation between isolated lissencephaly, Miller-Dieker syndrome, and other phenotypes secondary to deletions of 17p13.3". Am. J. Hum. Genet. 72 (4): 918–30. PMID 12621583.
- Toyo-oka K, Shionoya A, Gambello MJ; et al. (2003). "14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome". Nat. Genet. 34 (3): 274–85. doi:10.1038/ng1169. PMID 12796778.
- Morris JA, Kandpal G, Ma L, Austin CP (2004). "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation". Hum. Mol. Genet. 12 (13): 1591–608. PMID 12812986.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Brandon NJ, Handford EJ, Schurov I; et al. (2004). "Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders". Mol. Cell. Neurosci. 25 (1): 42–55. doi:10.1016/j.mcn.2003.09.009. PMID 14962739.
- Liang Y, Yu W, Li Y; et al. (2004). "Nudel functions in membrane traffic mainly through association with Lis1 and cytoplasmic dynein". J. Cell Biol. 164 (4): 557–66. doi:10.1083/jcb.200308058. PMID 14970193.
- Suzuki Y, Yamashita R, Shirota M; et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMID 15342556.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Tarricone C, Perrina F, Monzani S; et al. (2005). "Coupling PAF signaling to dynein regulation: structure of LIS1 in complex with PAF-acetylhydrolase". Neuron. 44 (5): 809–21. doi:10.1016/j.neuron.2004.11.019. PMID 15572112.
- Hayashi MA, Portaro FC, Bastos MF; et al. (2005). "Inhibition of NUDEL (nuclear distribution element-like)-oligopeptidase activity by disrupted-in-schizophrenia 1". Proc. Natl. Acad. Sci. U.S.A. 102 (10): 3828–33. doi:10.1073/pnas.0500330102. PMID 15728732.
- Guerreiro JR, Winnischofer SM, Bastos MF; et al. (2005). "Cloning and characterization of the human and rabbit NUDEL-oligopeptidase promoters and their negative regulation". Biochim. Biophys. Acta. 1730 (1): 77–84. doi:10.1016/j.bbaexp.2005.06.001. PMID 16005531.
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