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{{Infobox_gene}}
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'''Neuron navigator 2''' is a [[protein]] that in humans is encoded by the ''NAV2'' [[gene]].<ref name="pmid12079279">{{cite journal | vauthors = Maes T, Barcelo A, Buesa C | title = Neuron navigator: a human gene family with homology to unc-53, a cell guidance gene from Caenorhabditis elegans | journal = Genomics | volume = 80 | issue = 1 | pages = 21–30 |date=Jun 2002 | pmid = 12079279 | pmc =  | doi =10.1006/geno.2002.6799 }}</ref><ref name="pmid12062803">{{cite journal | vauthors = Coy JF, Wiemann S, Bechmann I, Bachner D, Nitsch R, Kretz O, Christiansen H, Poustka A | title = Pore membrane and/or filament interacting like protein 1 (POMFIL1) is predominantly expressed in the nervous system and encodes different protein isoforms | journal = Gene | volume = 290 | issue = 1–2 | pages = 73–94 |date=Jun 2002 | pmid = 12062803 | pmc =  | doi =10.1016/S0378-1119(02)00567-X }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NAV2 neuron navigator 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=89797| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = Neuron navigator 2
| HGNCid = 15997
| Symbol = NAV2
| AltSymbols =; FLJ10633; FLJ11030; FLJ23707; HELAD1; KIAA1419; POMFIL2; RAINB1; STEERIN2
| OMIM = 607026
| ECnumber =
| Homologene = 52330
| MGIid =
  | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004386 |text = helicase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0017111 |text = nucleoside-triphosphatase activity}}
  | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}  
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 89797
    | Hs_Ensembl =
    | Hs_RefseqProtein = NP_660093
    | Hs_RefseqmRNA = NM_145117
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start =
    | Hs_GenLoc_end =
    | Hs_Uniprot =
    | Mm_EntrezGene =
    | Mm_Ensembl =
    | Mm_RefseqmRNA =   
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start =   
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Neuron navigator 2''', also known as '''NAV2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NAV2 neuron navigator 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=89797| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =
| summary_text = The vitamin A metabolite, all-trans retinoic acid (atRA), plays an important role in neuronal development, including neurite outgrowth. RAINB1 is an atRA-responsive gene.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: NAV2 neuron navigator 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=89797| accessdate = }}</ref>
| summary_text = The [[vitamin A]] metabolite, all-trans retinoic acid (atRA), plays an important role in neuronal development, including neurite outgrowth. RAINB1 is an atRA-responsive gene.<ref name="entrez"/>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading
| citations =  
| citations =
*{{cite journal | author=Nakajima D, Okazaki N, Yamakawa H, ''et al.'' |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99-106 |year= 2003 |pmid= 12168954 |doi=  }}
*{{cite journal   |vauthors=Nakajima D, Okazaki N, Yamakawa H, etal |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=10.1093/dnares/9.3.99 }}
*{{cite journal | author=Hillier LD, Lennon G, Becker M, ''et al.'' |title=Generation and analysis of 280,000 human expressed sequence tags. |journal=Genome Res. |volume=6 |issue= 9 |pages= 807-28 |year= 1997 |pmid= 8889549 |doi=  }}
*{{cite journal   |vauthors=Hillier LD, Lennon G, Becker M, etal |title=Generation and analysis of 280,000 human expressed sequence tags |journal=Genome Res. |volume=6 |issue= 9 |pages= 807–28 |year= 1997 |pmid= 8889549 |doi=10.1101/gr.6.9.807 }}
*{{cite journal | author=Nagase T, Kikuno R, Ishikawa KI, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 1 |pages= 65-73 |year= 2000 |pmid= 10718198 |doi=  }}
*{{cite journal   |vauthors=Nagase T, Kikuno R, Ishikawa KI, etal |title=Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro |journal=DNA Res. |volume=7 |issue= 1 |pages= 65–73 |year= 2000 |pmid= 10718198 |doi=10.1093/dnares/7.1.65 }}
*{{cite journal | author=Dias Neto E, Correa RG, Verjovski-Almeida S, ''et al.'' |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491-6 |year= 2000 |pmid= 10737800 |doi=  }}
*{{cite journal   |vauthors=Dias Neto E, Correa RG, Verjovski-Almeida S, etal |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491–6 |year= 2000 |pmid= 10737800 |doi=10.1073/pnas.97.7.3491  | pmc=16267 }}
*{{cite journal  | author=Merrill RA, Plum LA, Kaiser ME, Clagett-Dame M |title=A mammalian homolog of unc-53 is regulated by all-trans retinoic acid in neuroblastoma cells and embryos. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 6 |pages= 3422-7 |year= 2002 |pmid= 11904404 |doi= 10.1073/pnas.052017399 }}
*{{cite journal  | vauthors=Merrill RA, Plum LA, Kaiser ME, Clagett-Dame M |title=A mammalian homolog of unc-53 is regulated by all-trans retinoic acid in neuroblastoma cells and embryos |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 6 |pages= 3422–7 |year= 2002 |pmid= 11904404 |doi= 10.1073/pnas.052017399  | pmc=122539 }}
*{{cite journal | author=Coy JF, Wiemann S, Bechmann I, ''et al.'' |title=Pore membrane and/or filament interacting like protein 1 (POMFIL1) is predominantly expressed in the nervous system and encodes different protein isoforms. |journal=Gene |volume=290 |issue= 1-2 |pages= 73-94 |year= 2002 |pmid= 12062803 |doi=  }}
*{{cite journal   |vauthors=Ishiguro H, Shimokawa T, Tsunoda T, etal |title=Isolation of HELAD1, a novel human helicase gene up-regulated in colorectal carcinomas |journal=Oncogene |volume=21 |issue= 41 |pages= 6387–94 |year= 2002 |pmid= 12214280 |doi= 10.1038/sj.onc.1205751 }}
*{{cite journal | author=Maes T, Barceló A, Buesa C |title=Neuron navigator: a human gene family with homology to unc-53, a cell guidance gene from Caenorhabditis elegans. |journal=Genomics |volume=80 |issue= 1 |pages= 21-30 |year= 2003 |pmid= 12079279 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Ishiguro H, Shimokawa T, Tsunoda T, ''et al.'' |title=Isolation of HELAD1, a novel human helicase gene up-regulated in colorectal carcinomas. |journal=Oncogene |volume=21 |issue= 41 |pages= 6387-94 |year= 2002 |pmid= 12214280 |doi= 10.1038/sj.onc.1205751 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Mitin NY, Ramocki MB, Zullo AJ, etal |title=Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization |journal=J. Biol. Chem. |volume=279 |issue= 21 |pages= 22353–61 |year= 2004 |pmid= 15031288 |doi= 10.1074/jbc.M312867200 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Tsutsumi S, Kamata N, Vokes TJ, etal |title=The Novel Gene Encoding a Putative Transmembrane Protein Is Mutated in Gnathodiaphyseal Dysplasia (GDD) |journal=Am. J. Hum. Genet. |volume=74 |issue= 6 |pages= 1255–61 |year= 2004 |pmid= 15124103 |doi= 10.1086/421527 | pmc=1182089 }}
*{{cite journal | author=Mitin NY, Ramocki MB, Zullo AJ, ''et al.'' |title=Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization. |journal=J. Biol. Chem. |volume=279 |issue= 21 |pages= 22353-61 |year= 2004 |pmid= 15031288 |doi= 10.1074/jbc.M312867200 }}
*{{cite journal   |vauthors=Peeters PJ, Baker A, Goris I, etal |title=Sensory deficits in mice hypomorphic for a mammalian homologue of unc-53 |journal=Brain Res. Dev. Brain Res. |volume=150 |issue= 2 |pages= 89–101 |year= 2004 |pmid= 15158073 |doi= 10.1016/j.devbrainres.2004.03.004 }}
*{{cite journal | author=Tsutsumi S, Kamata N, Vokes TJ, ''et al.'' |title=The novel gene encoding a putative transmembrane protein is mutated in gnathodiaphyseal dysplasia (GDD). |journal=Am. J. Hum. Genet. |volume=74 |issue= 6 |pages= 1255-61 |year= 2004 |pmid= 15124103 |doi= 10.1086/421527 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Peeters PJ, Baker A, Goris I, ''et al.'' |title=Sensory deficits in mice hypomorphic for a mammalian homologue of unc-53. |journal=Brain Res. Dev. Brain Res. |volume=150 |issue= 2 |pages= 89-101 |year= 2004 |pmid= 15158073 |doi= 10.1016/j.devbrainres.2004.03.004 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Beausoleil SA, Villén J, Gerber SA, etal |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal   |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Beausoleil SA, Villén J, Gerber SA, ''et al.'' |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285-92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
}}
}}
{{refend}}
{{refend}}
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[[Category:Human proteins]]


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Latest revision as of 12:31, 5 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Neuron navigator 2 is a protein that in humans is encoded by the NAV2 gene.[1][2][3]

The vitamin A metabolite, all-trans retinoic acid (atRA), plays an important role in neuronal development, including neurite outgrowth. RAINB1 is an atRA-responsive gene.[3]

References

  1. ↑ Maes T, Barcelo A, Buesa C (Jun 2002). "Neuron navigator: a human gene family with homology to unc-53, a cell guidance gene from Caenorhabditis elegans". Genomics. 80 (1): 21–30. doi:10.1006/geno.2002.6799. PMID 12079279.
  2. ↑ Coy JF, Wiemann S, Bechmann I, Bachner D, Nitsch R, Kretz O, Christiansen H, Poustka A (Jun 2002). "Pore membrane and/or filament interacting like protein 1 (POMFIL1) is predominantly expressed in the nervous system and encodes different protein isoforms". Gene. 290 (1–2): 73–94. doi:10.1016/S0378-1119(02)00567-X. PMID 12062803.
  3. ↑ 3.0 3.1 "Entrez Gene: NAV2 neuron navigator 2".

Further reading


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