Myxedema coma history and symptoms: Difference between revisions

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* Thyroid hormone therapy that was inappropriately discontinued
* Thyroid hormone therapy that was inappropriately discontinued
==Symptoms==
==Symptoms==
The function of all organ systems and various metabolic pathways are compromised in hypothyroidism. The cardinal symptoms of myxedema coma are the sensory impairment and hypothermia. The accumulation in the interstitial tissue of mucopolysaccharides and water leads to myxedema that compromises large part of the tissues.
Symptoms of myxedema coma can be summarized in the following table:<ref name="pmid17127141">{{cite journal |vauthors=Wartofsky L |title=Myxedema coma |journal=Endocrinol. Metab. Clin. North Am. |volume=35 |issue=4 |pages=687–98, vii–viii |year=2006 |pmid=17127141 |doi=10.1016/j.ecl.2006.09.003 |url=}}</ref>
Symptoms of myxedema coma can be summarized in the following table:<ref name="pmid17127141">{{cite journal |vauthors=Wartofsky L |title=Myxedema coma |journal=Endocrinol. Metab. Clin. North Am. |volume=35 |issue=4 |pages=687–98, vii–viii |year=2006 |pmid=17127141 |doi=10.1016/j.ecl.2006.09.003 |url=}}</ref>
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Revision as of 04:13, 10 October 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Aditya Ganti M.B.B.S. [2]

Overview

History

  • History of thyroid disease
  • History of radioiodine therapy or thyroidectomy,
  • Thyroid hormone therapy that was inappropriately discontinued

Symptoms

The function of all organ systems and various metabolic pathways are compromised in hypothyroidism. The cardinal symptoms of myxedema coma are the sensory impairment and hypothermia. The accumulation in the interstitial tissue of mucopolysaccharides and water leads to myxedema that compromises large part of the tissues. Symptoms of myxedema coma can be summarized in the following table:[1]

Organ system involved Manifestations
CNS
  • Lethargy
  • Poor memory
  • Cognitive dysfunction
  • Depression
  • Psychosis
  • Hypothermia
  • Focal or generalized seizures
Cardiovascular
  • SOB
  • Chest pain
Pulmonary
Gastro-intestinal
  • Anorexia
  • Nausea
  • Abdominal pain
  • Constipation
Renal and electrolyte
  • Bladder atony with urinary retention
Systemic Presence of normal temperature in myxedema

indicates presence of infection

References

  1. Wartofsky L (2006). "Myxedema coma". Endocrinol. Metab. Clin. North Am. 35 (4): 687–98, vii–viii. doi:10.1016/j.ecl.2006.09.003. PMID 17127141.