Myeloproliferative neoplasm other diagnostic studies: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Myeloproliferative disease}} | {{Myeloproliferative disease}} | ||
{{CMG}} {{AE}} {{MJK}} | {{CMG}} {{AE}} {{MJK}} {{shyam}} | ||
==Overview== | ==Overview== | ||
Other diagnostic studies for myeloproliferative neoplasm include [[bone marrow aspiration]] and [[biopsy|trephine biopsy]], [[lumbar puncture]], and [[lymph node biopsy]]. | Other diagnostic studies for myeloproliferative neoplasm include [[bone marrow aspiration]] and [[biopsy|trephine biopsy]], [[erythropoietin]] level, [[lumbar puncture]], and [[lymph node biopsy]]. | ||
==Other diagnostic studies== | ==Other diagnostic studies== | ||
Other diagnostic studies for myeloproliferative neoplasm include:<ref name="cancer.ca">Canadian Cancer Society.2015.http://www.cancer.ca/en/cancer-information/cancer-type/leukemia-chronic-myelogenous-cml/diagnosis/?region=ab</ref><ref>{{cite book |author=Levene, Malcolm I.; Lewis, S. M.; Bain, Barbara J.; Imelda Bates|title=Dacie & Lewis Practical Haematology |publisher=W B Saunders |location=London |year= |pages= |isbn=0-443-06377-X |pages=586}}</ref> | Other diagnostic studies for myeloproliferative neoplasm include:<ref name="cancer.ca">Canadian Cancer Society.2015.http://www.cancer.ca/en/cancer-information/cancer-type/leukemia-chronic-myelogenous-cml/diagnosis/?region=ab</ref><ref>{{cite book |author=Levene, Malcolm I.; Lewis, S. M.; Bain, Barbara J.; Imelda Bates|title=Dacie & Lewis Practical Haematology |publisher=W B Saunders |location=London |year= |pages= |isbn=0-443-06377-X |pages=586}}</ref> | ||
*[[Bone marrow aspiration]] and [[biopsy|trephine biopsy]]: This is an invasive diagnostic procedure that is sometimes required for the diagnosis of myeloproliferative neoplasm. Bone marrow biopsy usually shows high proportions of [[leukocytes]], [[erythrocytes]], and [[thrombocytes]]. This is referred to as [[panmyelosis]]. | *[[Bone marrow aspiration]] and [[biopsy|trephine biopsy]]: This is an invasive diagnostic procedure that is sometimes required for the diagnosis of myeloproliferative neoplasm. Bone marrow biopsy usually shows high proportions of [[leukocytes]], [[erythrocytes]], and [[thrombocytes]]. This is referred to as [[panmyelosis]] or [[hypercellularity]]. Cellularity normally decreases with age, but the cellularity will relatively high in patients with myeloproliferative neoplasm. The findings on a bone marrow biopsy constitute one of the major diagnostic criteria for various subtypes of myeloproliferative neoplasm in the 2016 WHO classification.<ref name="pmid27069254">{{cite journal| author=Arber DA, Orazi A, Hasserjian R, Thiele J, Borowitz MJ, Le Beau MM et al.| title=The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. | journal=Blood | year= 2016 | volume= 127 | issue= 20 | pages= 2391-405 | pmid=27069254 | doi=10.1182/blood-2016-03-643544 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27069254 }} </ref> | ||
*[[Erythropoietin]] level: [[Erythropoietin]] level is usually low in polycythemia vera, one of the subtypes of myeloproliferative neoplasm. This is because polycythemia vera is characterized by autonomous production of [[red blood cells]] in an erythropoietin-independent manner. | *[[Erythropoietin]] level: [[Erythropoietin]] level is usually low in [[polycythemia vera]], one of the subtypes of myeloproliferative neoplasm. This is because polycythemia vera is characterized by autonomous production of [[red blood cells]] in an erythropoietin-independent manner. | ||
*[[Lumbar puncture]] | *[[Lumbar puncture]]: This is used to detect any metastasis to the [[cerebral spinal fluid]] (CSF), which is rare. | ||
: | *[[Lymph node biopsy]]: This is used to obtain a diagnostic specimen, or to detect and/or determine the type of leukemic cells if leukemia is present. | ||
*[[Lymph node biopsy]] | |||
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==Gallery== | ==Gallery== | ||
Latest revision as of 15:51, 28 June 2018
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Myeloproliferative Neoplasm Microchapters |
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Differentiating myeloproliferative neoplasm from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2] Shyam Patel [3]
Overview
Other diagnostic studies for myeloproliferative neoplasm include bone marrow aspiration and trephine biopsy, erythropoietin level, lumbar puncture, and lymph node biopsy.
Other diagnostic studies
Other diagnostic studies for myeloproliferative neoplasm include:[1][2]
- Bone marrow aspiration and trephine biopsy: This is an invasive diagnostic procedure that is sometimes required for the diagnosis of myeloproliferative neoplasm. Bone marrow biopsy usually shows high proportions of leukocytes, erythrocytes, and thrombocytes. This is referred to as panmyelosis or hypercellularity. Cellularity normally decreases with age, but the cellularity will relatively high in patients with myeloproliferative neoplasm. The findings on a bone marrow biopsy constitute one of the major diagnostic criteria for various subtypes of myeloproliferative neoplasm in the 2016 WHO classification.[3]
- Erythropoietin level: Erythropoietin level is usually low in polycythemia vera, one of the subtypes of myeloproliferative neoplasm. This is because polycythemia vera is characterized by autonomous production of red blood cells in an erythropoietin-independent manner.
- Lumbar puncture: This is used to detect any metastasis to the cerebral spinal fluid (CSF), which is rare.
- Lymph node biopsy: This is used to obtain a diagnostic specimen, or to detect and/or determine the type of leukemic cells if leukemia is present.
Gallery
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![Bone marrow aspiration and biopsy. After a small area of skin is numbed, a Jamshidi needle (a long, hollow needle) is inserted into the patient’s hip bone. Samples of blood, bone, and bone marrow are removed for examination under a microscope.[4]](/images/e/e4/CDR554337-274.jpg)
Bone marrow aspiration and biopsy. After a small area of skin is numbed, a Jamshidi needle (a long, hollow needle) is inserted into the patient’s hip bone. Samples of blood, bone, and bone marrow are removed for examination under a microscope.[4]
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Bone marrow aspiration and biopsy. After a small area of skin is numbed, a Jamshidi needle (a long, hollow needle) is inserted into the patient’s hip bone. Samples of blood, bone, and bone marrow are removed for examination under a microscope.[4]
![Bone marrow aspiration and biopsy. After a small area of skin is numbed, a Jamshidi needle (a long, hollow needle) is inserted into the patient’s hip bone. Samples of blood, bone, and bone marrow are removed for examination under a microscope.[4]](/index.php/File:CDR554337-274.jpg)
References
- ↑ Canadian Cancer Society.2015.http://www.cancer.ca/en/cancer-information/cancer-type/leukemia-chronic-myelogenous-cml/diagnosis/?region=ab
- ↑ Levene, Malcolm I.; Lewis, S. M.; Bain, Barbara J.; Imelda Bates. Dacie & Lewis Practical Haematology. London: W B Saunders. p. 586. ISBN 0-443-06377-X.
- ↑ Arber DA, Orazi A, Hasserjian R, Thiele J, Borowitz MJ, Le Beau MM; et al. (2016). "The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia". Blood. 127 (20): 2391–405. doi:10.1182/blood-2016-03-643544. PMID 27069254.
- ↑ 4.0 4.1 National Cancer Institute. Physician Data Query Database 2015.http://www.cancer.gov/types/leukemia/patient/cml-treatment-pdq