Myelodysplastic syndrome laboratory findings: Difference between revisions

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==Overview==
==Overview==
Laboratory findings consistent with the diagnosis of myelodysplastic syndrome include abnormal complete blood count, peripheral blood smear, cytogenetic analysis, immunohistochemistry, and bone marrow biopsy.<ref name=cancergov5>Tests to examine and diagnose myelodysplastic syndromes. National Cancer Institute 2015. http://www.cancer.gov/types/myeloproliferative/patient/myelodysplastic-treatment-pdq. Accessed on December 14, 2015</ref>  
Laboratory findings consistent with the diagnosis of myelodysplastic syndrome include abnormal [[complete blood count]], [[peripheral blood smear]], cytogenetic analysis, [[immunohistochemistry]], and [[bone marrow biopsy]].<ref name=cancergov5>Tests to examine and diagnose myelodysplastic syndromes. National Cancer Institute 2015. http://www.cancer.gov/types/myeloproliferative/patient/myelodysplastic-treatment-pdq. Accessed on December 14, 2015</ref>  
==Laboratory Findings==
==Laboratory Findings==
Laboratory findings consistent with the diagnosis of myelodysplastic syndrome include abnormal complete blood count, peripheral blood smear, cytogenetic analysis, immunohistochemistry, and bone marrow biopsy.<ref name=cancergov5>Tests to examine and diagnose myelodysplastic syndromes. National Cancer Institute 2015. http://www.cancer.gov/types/myeloproliferative/patient/myelodysplastic-treatment-pdq. Accessed on December 14, 2015</ref>  
Laboratory findings consistent with the diagnosis of myelodysplastic syndrome include abnormal [[complete blood count]], [[peripheral blood smear]], cytogenetic analysis, [[immunohistochemistry]], and [[bone marrow biopsy]].<ref name=cancergov5>Tests to examine and diagnose myelodysplastic syndromes. National Cancer Institute 2015. http://www.cancer.gov/types/myeloproliferative/patient/myelodysplastic-treatment-pdq. Accessed on December 14, 2015</ref>  
===Complete Blood Count===
===Complete Blood Count===
On [[complete blood count]], characteristic findings of myelodysplastic syndrome include:<ref name=cancergov5>Tests to examine and diagnose myelodysplastic syndromes. National Cancer Institute 2015. http://www.cancer.gov/types/myeloproliferative/patient/myelodysplastic-treatment-pdq. Accessed on December 14, 2015</ref>  
On [[complete blood count]], characteristic findings of myelodysplastic syndrome include:<ref name=cancergov5>Tests to examine and diagnose myelodysplastic syndromes. National Cancer Institute 2015. http://www.cancer.gov/types/myeloproliferative/patient/myelodysplastic-treatment-pdq. Accessed on December 14, 2015</ref>  

Revision as of 21:31, 14 December 2015

Myelodysplastic syndrome Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Nawal Muazam M.D.[2]

Overview

Laboratory findings consistent with the diagnosis of myelodysplastic syndrome include abnormal complete blood count, peripheral blood smear, cytogenetic analysis, immunohistochemistry, and bone marrow biopsy.[1]

Laboratory Findings

Laboratory findings consistent with the diagnosis of myelodysplastic syndrome include abnormal complete blood count, peripheral blood smear, cytogenetic analysis, immunohistochemistry, and bone marrow biopsy.[1]

Complete Blood Count

On complete blood count, characteristic findings of myelodysplastic syndrome include:[1]

Peripheral Blood Smear

On peripheral blood smear, characteristic findings of myelodysplastic syndrome include:[2][3][4][5]

  • Macro-ovalocytes
  • Basophilic stippling
  • Howell-Jolly body
  • Acquired or pseudo-Pelger-Huët anomaly

Cytogenetic analysis

On cytogenetic analysis, characteristic findings of myelodysplastic syndrome include:[6][7]

  • Deletions within the long arm of chromosome 5
  • Deletions within the short arm of chromosome 17
  • Monosomy 7
  • Monosomy 8

Bone marrow aspiration and biopsy

On bone marrow biopsy, findings of myelodysplastic syndrome include:[8]

  • Abnormal erythropoiesis
  • Abnormal myelopoiesis

References

  1. 1.0 1.1 1.2 Tests to examine and diagnose myelodysplastic syndromes. National Cancer Institute 2015. http://www.cancer.gov/types/myeloproliferative/patient/myelodysplastic-treatment-pdq. Accessed on December 14, 2015
  2. Causes of macrocytosis. Wikipedia (2015). https://en.wikipedia.org/wiki/Macrocytosis. Accessed on December 14, 2015
  3. Basophilic stippling. Wikipedia (2015). https://en.wikipedia.org/wiki/Basophilic_stippling. Accessed on December 14, 2015
  4. Causes of Howell-Jolly body. Wikipedia (2015). https://en.wikipedia.org/wiki/Howell%E2%80%93Jolly_body. Accessed on December 14, 2015
  5. Acquired or pseudo-Pelger-Huët anomaly. Wikipedia (2015). https://en.wikipedia.org/wiki/Pelger%E2%80%93Huet_anomaly. Accessed on December 14, 2015
  6. Cytogenetics of myelodysplastic syndromes. Librepathology (2015). http://librepathology.org/wiki/index.php/Myelodysplastic_syndromes. Accessed on December 8, 2015
  7. Haase, Detlef (2008). "Cytogenetic features in myelodysplastic syndromes". Annals of Hematology. 87 (7): 515–526. doi:10.1007/s00277-008-0483-y. ISSN 0939-5555.
  8. Tricot, G.; Wolf-Peeters, C. De; Hendrickx, B.; Verwilghen, R. L. (1984). "Bone marrow histology in myelodysplastic syndromes". British Journal of Haematology. 57 (3): 423–430. doi:10.1111/j.1365-2141.1984.tb02916.x. ISSN 0007-1048.


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