Myelodysplastic syndrome laboratory findings: Difference between revisions

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{{Myelodysplastic syndrome}}
{{Myelodysplastic syndrome}}
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==Overview==
==Overview==
 
Laboratory findings consistent with the diagnosis of myelodysplastic syndrome include abnormal [[complete blood count]], [[peripheral blood smear]], cytogenetic analysis, and [[immunohistochemistry]].<ref name=cancergov5>Tests to examine and diagnose myelodysplastic syndromes. National Cancer Institute 2015. http://www.cancer.gov/types/myeloproliferative/patient/myelodysplastic-treatment-pdq. Accessed on December 14, 2015</ref><ref name=Macrocytosis>Causes of macrocytosis. Wikipedia (2015). https://en.wikipedia.org/wiki/Macrocytosis. Accessed on December 14, 2015</ref><ref name=Basophilic>Basophilic stippling. Wikipedia (2015). https://en.wikipedia.org/wiki/Basophilic_stippling. Accessed on December 14, 2015</ref><ref name=Howell>Causes of Howell-Jolly body. Wikipedia (2015). https://en.wikipedia.org/wiki/Howell%E2%80%93Jolly_body. Accessed on December 14, 2015</ref><ref name=Pseudopelger>Acquired or pseudo-Pelger-Huët anomaly. Wikipedia (2015). https://en.wikipedia.org/wiki/Pelger%E2%80%93Huet_anomaly. Accessed on December 14, 2015</ref><ref name=Librepathology2>Cytogenetics of myelodysplastic syndromes. Librepathology (2015). http://librepathology.org/wiki/index.php/Myelodysplastic_syndromes. Accessed on December 8, 2015</ref><ref name="Haase2008">{{cite journal|last1=Haase|first1=Detlef|title=Cytogenetic features in myelodysplastic syndromes|journal=Annals of Hematology|volume=87|issue=7|year=2008|pages=515–526|issn=0939-5555|doi=10.1007/s00277-008-0483-y}}</ref><ref name="TricotWolf-Peeters1984">{{cite journal|last1=Tricot|first1=G.|last2=Wolf-Peeters|first2=C. De|last3=Hendrickx|first3=B.|last4=Verwilghen|first4=R. L.|title=Bone marrow histology in myelodysplastic syndromes.|journal=British Journal of Haematology|volume=57|issue=3|year=1984|pages=423–430|issn=0007-1048|doi=10.1111/j.1365-2141.1984.tb02916.x}}</ref>
==Laboratory Findings==
Laboratory findings consistent with the diagnosis of myelodysplastic syndrome include abnormal [[complete blood count]], [[peripheral blood smear]], cytogenetic analysis, [[immunohistochemistry]], and [[bone marrow biopsy]].<ref name=cancergov5>Tests to examine and diagnose myelodysplastic syndromes. National Cancer Institute 2015. http://www.cancer.gov/types/myeloproliferative/patient/myelodysplastic-treatment-pdq. Accessed on December 14, 2015</ref>
===Complete Blood Count===
On [[complete blood count]], characteristic findings of myelodysplastic syndrome include:<ref name=cancergov5>Tests to examine and diagnose myelodysplastic syndromes. National Cancer Institute 2015. http://www.cancer.gov/types/myeloproliferative/patient/myelodysplastic-treatment-pdq. Accessed on December 14, 2015</ref>
*[[Anemia]]
*[[Thrombocytopenia]]
*[[Leukopenia]]
*[[Neutropenia]]
===Peripheral Blood Smear===
On [[peripheral blood smear]], characteristic findings of myelodysplastic syndrome include:<ref name=Macrocytosis>Causes of macrocytosis. Wikipedia (2015). https://en.wikipedia.org/wiki/Macrocytosis. Accessed on December 14, 2015</ref><ref name=Basophilic>Basophilic stippling. Wikipedia (2015). https://en.wikipedia.org/wiki/Basophilic_stippling. Accessed on December 14, 2015</ref><ref name=Howell>Causes of Howell-Jolly body. Wikipedia (2015). https://en.wikipedia.org/wiki/Howell%E2%80%93Jolly_body. Accessed on December 14, 2015</ref><ref name=Pseudopelger>Acquired or pseudo-Pelger-Huët anomaly. Wikipedia (2015). https://en.wikipedia.org/wiki/Pelger%E2%80%93Huet_anomaly. Accessed on December 14, 2015</ref>
*Macro-ovalocytes
*Basophilic stippling
*[[Howell-Jolly body]]
*Acquired or pseudo-Pelger-Huët anomaly
===Cytogenetic Analysis===
On cytogenetic analysis, characteristic findings of myelodysplastic syndrome include:<ref name=Librepathology2>Cytogenetics of myelodysplastic syndromes. Librepathology (2015). http://librepathology.org/wiki/index.php/Myelodysplastic_syndromes. Accessed on December 8, 2015</ref><ref name="Haase2008">{{cite journal|last1=Haase|first1=Detlef|title=Cytogenetic features in myelodysplastic syndromes|journal=Annals of Hematology|volume=87|issue=7|year=2008|pages=515–526|issn=0939-5555|doi=10.1007/s00277-008-0483-y}}</ref>
*Deletions within the long arm of chromosome 5
*Deletions within the short arm of chromosome 17
*Monosomy 7
*Monosomy 8
==References==
==References==
{{reflist|2}}
{{reflist|2}}
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[[Category:Disease]]
[[Category:Types of cancer]]
[[Category:Types of cancer]]
[[Category:Oncology]]
[[Category:Hematology]]
[[Category:Hematology]]


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Latest revision as of 02:49, 27 November 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Nawal Muazam M.D.[2]

Overview

Laboratory findings consistent with the diagnosis of myelodysplastic syndrome include abnormal complete blood count, peripheral blood smear, cytogenetic analysis, and immunohistochemistry.[1][2][3][4][5][6][7][8]

Laboratory Findings

Laboratory findings consistent with the diagnosis of myelodysplastic syndrome include abnormal complete blood count, peripheral blood smear, cytogenetic analysis, immunohistochemistry, and bone marrow biopsy.[1]

Complete Blood Count

On complete blood count, characteristic findings of myelodysplastic syndrome include:[1]

Peripheral Blood Smear

On peripheral blood smear, characteristic findings of myelodysplastic syndrome include:[2][3][4][5]

  • Macro-ovalocytes
  • Basophilic stippling
  • Howell-Jolly body
  • Acquired or pseudo-Pelger-Huët anomaly

Cytogenetic Analysis

On cytogenetic analysis, characteristic findings of myelodysplastic syndrome include:[6][7]

  • Deletions within the long arm of chromosome 5
  • Deletions within the short arm of chromosome 17
  • Monosomy 7
  • Monosomy 8

References

  1. 1.0 1.1 1.2 Tests to examine and diagnose myelodysplastic syndromes. National Cancer Institute 2015. http://www.cancer.gov/types/myeloproliferative/patient/myelodysplastic-treatment-pdq. Accessed on December 14, 2015
  2. 2.0 2.1 Causes of macrocytosis. Wikipedia (2015). https://en.wikipedia.org/wiki/Macrocytosis. Accessed on December 14, 2015
  3. 3.0 3.1 Basophilic stippling. Wikipedia (2015). https://en.wikipedia.org/wiki/Basophilic_stippling. Accessed on December 14, 2015
  4. 4.0 4.1 Causes of Howell-Jolly body. Wikipedia (2015). https://en.wikipedia.org/wiki/Howell%E2%80%93Jolly_body. Accessed on December 14, 2015
  5. 5.0 5.1 Acquired or pseudo-Pelger-Huët anomaly. Wikipedia (2015). https://en.wikipedia.org/wiki/Pelger%E2%80%93Huet_anomaly. Accessed on December 14, 2015
  6. 6.0 6.1 Cytogenetics of myelodysplastic syndromes. Librepathology (2015). http://librepathology.org/wiki/index.php/Myelodysplastic_syndromes. Accessed on December 8, 2015
  7. 7.0 7.1 Haase, Detlef (2008). "Cytogenetic features in myelodysplastic syndromes". Annals of Hematology. 87 (7): 515–526. doi:10.1007/s00277-008-0483-y. ISSN 0939-5555.
  8. Tricot, G.; Wolf-Peeters, C. De; Hendrickx, B.; Verwilghen, R. L. (1984). "Bone marrow histology in myelodysplastic syndromes". British Journal of Haematology. 57 (3): 423–430. doi:10.1111/j.1365-2141.1984.tb02916.x. ISSN 0007-1048.


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