Myd88

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Myeloid differentiation primary response gene (88)
Identifiers
Symbols MYD88 ;
External IDs OMIM: 602170 MGI108005 HomoloGene1849
RNA expression pattern
File:PBB GE MYD88 209124 at tn.png
More reference expression data
Orthologs

| | bgcolor="#C3FDB8" | Human | bgcolor="#C3FDB8" | Mouse |-

    | bgcolor="#C3FDB8" | Entrez 
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| 4615
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| 17874

|-

     | bgcolor="#C3FDB8" | Ensembl
     | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| ENSG00000172936
     | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| ENSMUSG00000032508

|-

    | bgcolor="#C3FDB8" | Uniprot
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| Q99836
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| Q0PM15

|-

    | bgcolor="#C3FDB8" | Refseq
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd" | NM_002468 (mRNA)
NP_002459 (protein)
| bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd" |NM_010851 (mRNA)
NP_034981 (protein)

|-

    | bgcolor="#C3FDB8" | Location
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"|  Chr 3: 38.16 - 38.16 Mb 
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"|  Chr 9: 119.18 -  119.19 Mb 

|-

|-

    | bgcolor="#C3FDB8" | Pubmed search 
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| [1]
| bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| [2]
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Myeloid differentiation primary response gene (88) (MYD88) is a universal adapter protein as it is used by all TLRs (except TLR 3) to activate transcription factor Nfkappa B. Mal is necessary to recruit Myd88 to TLR 2 and TLR 4. TLRs can use Myd88 dependent and independent pathways. MYD88 is also its human gene.[1]

Signaling pathway of toll-like receptors. Dashed grey lines represent unknown associations

History

MyD88 was originally discovered and cloned by Drs Dan A Liebermann& Barbara Hoffman as "Myeloid Differentiation primary response gene 88". [2]

MAL was found by Katherine Fitzgerald et al.[3]

References

  1. "Entrez Gene: MYD88 Myeloid differentiation primary response gene (88)".
  2. Lord KA, Hoffman-Liebermann B, Liebermann DA (1990). "Nucleotide sequence and expression of a cDNA encoding MyD88, a novel myeloid differentiation primary response gene induced by IL6". Oncogene. 5 (7): 1095–7. PMID 2374694.
  3. Fitzgerald KA, Palsson-McDermott EM, Bowie AG; et al. (2001). "Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction". Nature. 413 (6851): 78–83. doi:10.1038/35092578. PMID 11544529.

Further reading

  • Hardiman G, Rock FL, Balasubramanian S; et al. (1997). "Molecular characterization and modular analysis of human MyD88". Oncogene. 13 (11): 2467–75. PMID 8957090.
  • Bonnert TP, Garka KE, Parnet P; et al. (1997). "The cloning and characterization of human MyD88: a member of an IL-1 receptor related family". FEBS Lett. 402 (1): 81–4. PMID 9013863.
  • Hardiman G, Jenkins NA, Copeland NG; et al. (1998). "Genetic structure and chromosomal mapping of MyD88". Genomics. 45 (2): 332–9. doi:10.1006/geno.1997.4940. PMID 9344657.
  • Muzio M, Ni J, Feng P, Dixit VM (1997). "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling". Science. 278 (5343): 1612–5. PMID 9374458.
  • Jaunin F, Burns K, Tschopp J; et al. (1998). "Ultrastructural distribution of the death-domain-containing MyD88 protein in HeLa cells". Exp. Cell Res. 243 (1): 67–75. doi:10.1006/excr.1998.4131. PMID 9716450.
  • Wesche H, Gao X, Li X; et al. (1999). "IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family". J. Biol. Chem. 274 (27): 19403–10. PMID 10383454.
  • Burns K, Clatworthy J, Martin L; et al. (2000). "Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor". Nat. Cell Biol. 2 (6): 346–51. doi:10.1038/35014038. PMID 10854325.
  • Aliprantis AO, Yang RB, Weiss DS; et al. (2000). "The apoptotic signaling pathway activated by Toll-like receptor-2". EMBO J. 19 (13): 3325–36. doi:10.1093/emboj/19.13.3325. PMID 10880445.
  • Rhee SH, Hwang D (2000). "Murine TOLL-like receptor 4 confers lipopolysaccharide responsiveness as determined by activation of NF kappa B and expression of the inducible cyclooxygenase". J. Biol. Chem. 275 (44): 34035–40. doi:10.1074/jbc.M007386200. PMID 10952994.
  • Fitzgerald KA, Palsson-McDermott EM, Bowie AG; et al. (2001). "Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction". Nature. 413 (6851): 78–83. doi:10.1038/35092578. PMID 11544529.
  • Tauszig-Delamasure S, Bilak H, Capovilla M; et al. (2002). "Drosophila MyD88 is required for the response to fungal and Gram-positive bacterial infections". Nat. Immunol. 3 (1): 91–7. doi:10.1038/ni747. PMID 11743586.
  • Bannerman DD, Tupper JC, Kelly JD; et al. (2002). "The Fas-associated death domain protein suppresses activation of NF-kappa B by LPS and IL-1 beta". J. Clin. Invest. 109 (3): 419–25. PMID 11828002.
  • Tamai R, Sakuta T, Matsushita K; et al. (2002). "Human gingival CD14(+) fibroblasts primed with gamma interferon increase production of interleukin-8 in response to lipopolysaccharide through up-regulation of membrane CD14 and MyD88 mRNA expression". Infect. Immun. 70 (3): 1272–8. PMID 11854210.
  • Radons J, Gabler S, Wesche H; et al. (2002). "Identification of essential regions in the cytoplasmic tail of interleukin-1 receptor accessory protein critical for interleukin-1 signaling". J. Biol. Chem. 277 (19): 16456–63. doi:10.1074/jbc.M201000200. PMID 11880380.
  • Janssens S, Burns K, Tschopp J, Beyaert R (2002). "Regulation of interleukin-1- and lipopolysaccharide-induced NF-kappaB activation by alternative splicing of MyD88". Curr. Biol. 12 (6): 467–71. PMID 11909531.
  • Li S, Strelow A, Fontana EJ, Wesche H (2002). "IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase". Proc. Natl. Acad. Sci. U.S.A. 99 (8): 5567–72. doi:10.1073/pnas.082100399. PMID 11960013.
  • Medvedev AE, Lentschat A, Wahl LM; et al. (2002). "Dysregulation of LPS-induced Toll-like receptor 4-MyD88 complex formation and IL-1 receptor-associated kinase 1 activation in endotoxin-tolerant cells". J. Immunol. 169 (9): 5209–16. PMID 12391239.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Raschi E, Testoni C, Bosisio D; et al. (2003). "Role of the MyD88 transduction signaling pathway in endothelial activation by antiphospholipid antibodies". Blood. 101 (9): 3495–500. doi:10.1182/blood-2002-08-2349. PMID 12531807.
  • Doyle SE, O'Connell R, Vaidya SA; et al. (2003). "Toll-like receptor 3 mediates a more potent antiviral response than Toll-like receptor 4". J. Immunol. 170 (7): 3565–71. PMID 12646618.

External links


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