Mycosis fungoides classification: Difference between revisions

Jump to navigation Jump to search
Line 8: Line 8:
method 1], [classification
method 1], [classification
==Classification==
==Classification==
According to world Health Organization (WHO) and European Organization for Research and Treatment of Cancer (EORTC) classification, cutaneous T cell and NK cell lymphomas may be classified into the following types:
According to world Health Organization (WHO) and European Organization for Research and Treatment of Cancer (EORTC) classification, cutaneous T cell and NK cell lymphomas may be classified into the following types:<ref name="Matutes2018">{{cite journal|last1=Matutes|first1=E.|title=The 2017 WHO update on mature T- and natural killer (NK) cell neoplasms|journal=International Journal of Laboratory Hematology|volume=40|year=2018|pages=97–103|issn=17515521|doi=10.1111/ijlh.12817}}</ref>


*Mycosis fungoides
*Mycosis fungoides

Revision as of 15:30, 1 November 2018

Cutaneous T cell lymphoma Microchapters

Home

Patient Information

Overview

Classification

Mycosis fungoides
Sezary syndrome

Pathophysiology

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]

Overview

There are 3 classification methods used to classify cutaneous T cell lymphoma into several subtypes. Cutaneous T cell lymphoma may be classified into several subtypes based on WHO-EORTC classification.

method 1], [classification

Classification

According to world Health Organization (WHO) and European Organization for Research and Treatment of Cancer (EORTC) classification, cutaneous T cell and NK cell lymphomas may be classified into the following types:[1]

  • Mycosis fungoides
  • Mycosis fungoides variants and subtypes
    • Folliculotropic mycosis fungoides
    • Pagetoid reticulosis
    • Granulomatous slack skin
  • Sezary syndrome
  • Adult T cell leukemia/lymphoma
  • Primary cutaneous CD30+ lymphoproliferative disorders
    • Primary cutaneous anaplastic large cell lymphoma
    • Lymphomatoid papulosis
  • Subcutaneous panniculitis-like T cell lymphoma
  • Extranodal NK/T cell lymphoma, nasal type
  • Primary cutaneous peripheral T cell lymphoma, rare subtypes
    • Primary cutaneous gamma-delta T cell lymphoma
    • Primary cutaneous aggressive epidermotropic CD8+ T cell lymphoma (provisional)
    • Primary cutaneous CD4+ small/medium-sized pleomorphic T cell lymphoproliferative disorder (provisional)
    • Primary cutaneous acral CD8+ T cell lymphoma (provisional)
  • Primary cutaneous peripheral T cell lymphoma, not otherwise specified


Cutaneous T cell lymphoma classification[2]
Name Description
Mycosis fungoides (MF)
  • Most common form of cutaneous T cell lymphoma
  • Starts in the skin in areas of the body not usually exposed to the sun
  • May appear as a scaly, pink patches on the skin
  • Signs can progress to the development of skin tumors in more advanced cases
Sézary syndrome (SS)
  • Often the more aggressive form of cutaneous T cell lymphoma
  • An advanced form of mycosis fungoides
  • Affects skin, blood, and lymph nodes
  • Large areas of the skin are affected
  • Skin is often red, itchy, painful, and peeling
  • Skin tumors can also appear
  • Entire body can be affected, also known as "red man syndrome"
Cutaneous T cell lymphoma classification[3]
Name Description
Primary or cutaneous CD8-positive aggressive epidermotropic cytotoxic T-cell lymphoma
  • Characterized by localized or disseminated eruptive papules, nodules with tumors showing central ulceration, and necrosis or by superficial hyperkeratotic patches and plaques
  • Dissemination to other visceral sites (lung, testis, CNS, and oral mucosa)
  • Lymph nodes are seldom affected
  • Aggressive clinical course with median survival rate of 32 months
Primary cutaneous CD4-positive small/medium T-cell lymphoma
  • Clinical presentation is usually a solitary plaque or nodule, commonly on the face, neck, or upper trunk
  • The involvement of lower extremities is rare
  • Cutaneous patches are generally absent

References

  1. Matutes, E. (2018). "The 2017 WHO update on mature T- and natural killer (NK) cell neoplasms". International Journal of Laboratory Hematology. 40: 97–103. doi:10.1111/ijlh.12817. ISSN 1751-5521.
  2. Cutaneous T cell lymphoma. Canadian Cancer Society. http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/cutaneous-t-cell-lymphoma/?region=on Accessed on January 19, 2016
  3. Cutaneous T cell lymphoma. Surveillance, Epidemiology, and End Results . http://seer.cancer.gov/seertools/hemelymph/51f6cf56e3e27c3994bd52f7/ Accessed on January 19, 2016


Template:WikiDoc Sources