Multivitamins and mortality

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aarti Narayan, M.B.B.S [2]

Overview

Use of multivitamin supplements in the US has increased tremendously in past decade. According to the data from National Center for Health Statistics, over 50% of adults in the United States consume dietary supplements, with approximately 35% of adults taking multivitamin supplements. Studies on multivitamin supplements have shown conflicting evidence on their effect on mortality, with some studies demonstrating an increase in risk of death, whereas others reporting no change in mortality.

Landmark Studies

Iowa Women Health Study

• This study assessed the long term effects of multivitamin supplements on mortality. It included 38,772 women with a mean age of 61.6 years at baseline.
• The study found increase in risk of total mortality in women on dietary and vitamin supplements, with highest increase in mortality seen in women on iron supplements.