Multiprotein complex

Jump to navigation Jump to search
Bacillus amyloliquefaciens proteins in a complex

WikiDoc Resources for Multiprotein complex

Articles

Most recent articles on Multiprotein complex

Most cited articles on Multiprotein complex

Review articles on Multiprotein complex

Articles on Multiprotein complex in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Multiprotein complex

Images of Multiprotein complex

Photos of Multiprotein complex

Podcasts & MP3s on Multiprotein complex

Videos on Multiprotein complex

Evidence Based Medicine

Cochrane Collaboration on Multiprotein complex

Bandolier on Multiprotein complex

TRIP on Multiprotein complex

Clinical Trials

Ongoing Trials on Multiprotein complex at Clinical Trials.gov

Trial results on Multiprotein complex

Clinical Trials on Multiprotein complex at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Multiprotein complex

NICE Guidance on Multiprotein complex

NHS PRODIGY Guidance

FDA on Multiprotein complex

CDC on Multiprotein complex

Books

Books on Multiprotein complex

News

Multiprotein complex in the news

Be alerted to news on Multiprotein complex

News trends on Multiprotein complex

Commentary

Blogs on Multiprotein complex

Definitions

Definitions of Multiprotein complex

Patient Resources / Community

Patient resources on Multiprotein complex

Discussion groups on Multiprotein complex

Patient Handouts on Multiprotein complex

Directions to Hospitals Treating Multiprotein complex

Risk calculators and risk factors for Multiprotein complex

Healthcare Provider Resources

Symptoms of Multiprotein complex

Causes & Risk Factors for Multiprotein complex

Diagnostic studies for Multiprotein complex

Treatment of Multiprotein complex

Continuing Medical Education (CME)

CME Programs on Multiprotein complex

International

Multiprotein complex en Espanol

Multiprotein complex en Francais

Business

Multiprotein complex in the Marketplace

Patents on Multiprotein complex

Experimental / Informatics

List of terms related to Multiprotein complex


A multiprotein complex (or protein complex) is a group of two or more proteins. Protein complexes are a form of quaternary structure. Proteins in a protein complex are linked by non-covalent protein-protein interactions, and different protein complexes have different degrees of stability over time. Protein complex formation often serves to activate or inhibit one or more of the complex members. In this way protein complex formation can be similar to phosphorylation. A method that is commonly used for identifying the members of protein complexes is immunoprecipitation.

Understanding the functional interactions of proteins is an important research focus in biochemistry and cell biology. Protein complex formation often serves to activate or inhibit one or more of the complex members and in this way, protein complex formation can be similar to phosphorylation. These complexes are a cornerstone of many (if not most) biological processes and together they form various types of molecular machinery that perform a vast array of biological functions. Individual proteins can participate in the formation of a variety of different protein complexes. Different complexes perform different functions, and the same complex can perform very different functions that depend on a variety of factors. Some of these factors are:

  • Which cellular compartment the complex exists in
  • Which stage in the cell cycle the complexes are present
  • The nutritional status of the cell
  • Others

Many protein complexes are well understood, particularly in the model organism Saccharomyces cerevisiae (a strain of yeast). For this relatively simple organism, the study of protein complexes is now being performed genome wide and the elucidation of most protein complexes of the yeast is undergoing.

The molecular structure of protein complexes can be determined by experimental techniques such as X-ray crystallography or nuclear magnetic resonance. Increasingly the theoretical option of protein-protein docking is also becoming available.

Homomultmeric and heteromultimeric proteins

The subunits of a multimeric protein may be identical as in a homomultimeric protein or different as in a heteromultimeric protein.

The voltage-gated potassium channels in the plasma membrane of a neuron are heteromultimeric proteins composed of four of forty known alpha subunits. Subunits must be of the same subfamily to form the multimeric protein channel. The tertiary structure of the channel allows ions to flow through the hydrophobic plasma membrane. Connexons are an example of a homomultimeric protein composed of six identical connexins. A cluster of connexons forms the gap-junction in two neurons that transmit signals through an electrical synapse [1].

References

  1. [1]

External links

ca:Complex proteic de:Proteinkomplex uk:Білковий комплекс

Template:WH Template:WS