Multiple myeloma epidemiology and demographics: Difference between revisions

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Latest revision as of 22:47, 29 July 2020

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Hannan Javed, M.D.[2]; Haytham Allaham, M.D. [3]; Shyam Patel [4]

Overview

In 2012, the incidence of multiple myeloma was approximately 6.3 per 100,000 cases with a mortality rate of 3.3 per 100,000 cases in the United States. The prevalence of multiple myeloma was estimated to be 89,658 cases in 2012 in the United States. Multiple myeloma is the second most common blood cancer after non-Hodgkin's lymphoma and 14th most common cancer overall in United States. Males are more commonly affected with multiple myeloma than females; the male to female ratio is approximately 1.54 to 1. Multiple myeloma usually affects individuals of the African American race. Asian individuals are less likely to develop multiple myeloma. The incidence of multiple myeloma increases with age.

Epidemiology and Demographics

Incidence

The age-standardized incidence rate of multiple myeloma worldwide is 1.5 per 100,000 persons per year.^[1]^[2]
According to age-adjusted rates based in 2011-2015, the incidence of multiple myeloma was approximately 6.7 per 100,000 individuals with a case-fatality rate of 3.3 per 100,000 in the United States.^[3]^[2]
In 2018, multiple myeloma will constitute approximately 1.8% of the estimated new cancer cases.^[4]^[2]
In 2018, the estimated deaths caused by multiple myeloma will constitute 2.1% of all cancer mortality cases.^[5]^[2]
In 2018, approximately 30,770 people will be diagnosed with multiple myeloma.^[6]
In 2018, approximately 12,770 people die from multiple myeloma.^[2]
According to 2013-2015 data, approximately 0.8% of all people will have a diagnosis of multiple myeloma at some point during their lifetime in US.^[2]
According to an estimation in 2015, there were 124,733 people with myeloma living in the United States.^[2]
Multiple myeloma is the second most common hematologic malignancy, after non-Hodgkin lymphoma.^[1]
Since 1975, the overall multiple myeloma incidence has increased nearly 1 percent annually.^[4]
Solitary plasmacytoma accounts for approximately 5% of plasma cell neoplasms.^[7]

Multiple Myeloma Epidemiology
Estimated New Cases in 2018	30,770
% of All New Cancer Cases	1.8%
Estimated Deaths in 2018	12,770
% of All Cancer Deaths	2.1%
5 Years Survival Rate (2008-2014)	50.7%
Adopted from National Cancer Institute^[2]

Prevalence

Myeloma is the 14th leading cause of cancer death in the United States.^[5]
According to an estimation in 2015, there were 124,733 people with myeloma living in the United States.^[2]

Age

The incidence of multiple myeloma increases with age, and the median age at diagnosis is 69 years.^[2]

Percent of New Cases by Age Group
Age	Percent of New cases
<20
20-34	0.5%
35-44	2.8%
45-54	10.9%
55-64	23.2%
65-74	29.8%
75-84	23.7%
>84	9.0%
Adopted from National Cancer Institute^[2]

Gender

Males are more commonly affected with multiple myeloma than females. The male to female ratio is approximately 1.54 to 1.^[8]

Race

Among African Americans, multiple myeloma is one of the top 10 leading causes of cancer deaths.^[5]
The incidence of multiple myeloma in the African American population is more than the European American population.
African Americans have a 2-fold higher age-standardized incidence rate of multiple myeloma than Caucasians. The incidence of multiple myeloma in African Americans is 9.6 per 100,000 persons. The incidence of Caucasians is 4.1 per 100,000 persons.^[1]

New Cases per 100,000 Persons by Race/Ethnicity & Sex
Race	Female	Male
All Races	5.3	8.4
White	4.7	7.9
Black	11.6	15.9
Asian/Pacific Islander	3.1	4.9
American Indian/Alaska Native	5.5	6.2
Hispanic	5.0	7.6
Non-Hispanic	5.4	8.5
Adopted from National Cancer Institute^[2]

Gallery

Percent of new cases by age group: multiple myeloma.^[5]

Number of new cases per 100,000 persons by race/ethnicity & sex: multiple myeloma.^[5]>

Percent of deaths per age group: multiple myeloma.^[5]

Number of deaths per 100,000 persons by race/ethnicity & sex multiple myeloma.^[5]

Multiple myeloma percent of total new cancer csases in the United states.^[5]

New cases, deaths, and 5-Year relative survival.^[5]

References

↑ ^1.0 ^1.1 ^1.2 Hong J, Lee JH (2016). "Recent advances in multiple myeloma: a Korean perspective". Korean J Intern Med. 31 (5): 820–34. doi:10.3904/kjim.2015.408. PMC 5016289. PMID 27604794.
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 "Myeloma - Cancer Stat Facts".
↑ Plasma cell neoplasm.National cancer institute (2015)http://www.cancer.gov/types/myeloma/hp/myeloma-treatment-pdq#cit/section_1.1 Accessed on September, 20th 2015
↑ ^4.0 ^4.1 A snapshot of myeloma. National cancer institute(2014)http://www.cancer.gov/research/progress/snapshots/myeloma Accessed on September, 20th 2015
↑ ^5.00 ^5.01 ^5.02 ^5.03 ^5.04 ^5.05 ^5.06 ^5.07 ^5.08 ^5.09 ^5.10 Seer stat fact sheet. National cancer institute (2015)http://seer.cancer.gov/statfacts/html/mulmy.html Accessed on September, 20th 2015
↑ "Myeloma - Cancer Stat Facts".
↑ Jia R, Xue L, Liang H, Gao K, Li J, Zhang Z (2015). "Surgery combined with radiotherapy for the treatment of solitary plasmacytoma of the rib: a case report and review of the literature". J Cardiothorac Surg. 10: 125. doi:10.1186/s13019-015-0335-5. PMC 4605096. PMID 26464186.
↑ Multiple myeloma. Radiopaedia (2015)http://radiopaedia.org/articles/multiple-myeloma-1 Accessed on September, 20th 2015

[pmid27604794-1] 1.0 ^1.1 ^1.2 Hong J, Lee JH (2016). "Recent advances in multiple myeloma: a Korean perspective". Korean J Intern Med. 31 (5): 820–34. doi:10.3904/kjim.2015.408. PMC 5016289. PMID 27604794.

[urlMyeloma_-_Cancer_Stat_Facts-2] 2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 "Myeloma - Cancer Stat Facts".

[PCN-3] Plasma cell neoplasm.National cancer institute (2015)http://www.cancer.gov/types/myeloma/hp/myeloma-treatment-pdq#cit/section_1.1 Accessed on September, 20th 2015

[snap-4] 4.0 ^4.1 A snapshot of myeloma. National cancer institute(2014)http://www.cancer.gov/research/progress/snapshots/myeloma Accessed on September, 20th 2015

[seer-5] 5.00 ^5.01 ^5.02 ^5.03 ^5.04 ^5.05 ^5.06 ^5.07 ^5.08 ^5.09 ^5.10 Seer stat fact sheet. National cancer institute (2015)http://seer.cancer.gov/statfacts/html/mulmy.html Accessed on September, 20th 2015

[urlMyeloma_-_Cancer_Stat_Facts2-6] "Myeloma - Cancer Stat Facts".

[pmid26464186-7] Jia R, Xue L, Liang H, Gao K, Li J, Zhang Z (2015). "Surgery combined with radiotherapy for the treatment of solitary plasmacytoma of the rib: a case report and review of the literature". J Cardiothorac Surg. 10: 125. doi:10.1186/s13019-015-0335-5. PMC 4605096. PMID 26464186.

[radio-8] Multiple myeloma. Radiopaedia (2015)http://radiopaedia.org/articles/multiple-myeloma-1 Accessed on September, 20th 2015

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@@ Line 1: / Line 1: @@
 __NOTOC__
 {{Multiple myeloma}}
-{{CMG}} {{AE}} {{HMHJ}} {{AE}}{{HL}} {{shyam}}
+{{CMG}} {{AE}} {{HMHJ}}; {{HL}}; {{shyam}}
 ==Overview==
-In 2012, the incidence of multiple myeloma was approximately 6.3 per 100,000 cases with a mortality rate of 3.3 per 100,000 cases in the United States.<ref name="PCN">Plasma cell neoplasm.National cancer institute (2015)http://www.cancer.gov/types/myeloma/hp/myeloma-treatment-pdq#cit/section_1.1 Accessed on September, 20th 2015</ref> The prevalence of multiple myeloma was estimated to be 89,658 cases in 2012 in the United States.<ref name="seer">Seer stat fact sheet. National cancer institute (2015)http://seer.cancer.gov/statfacts/html/mulmy.html Accessed on September, 20th 2015</ref><ref name="wiki">Multiple myeloma. Wikipedia (2015)https://en.wikipedia.org/wiki/Multiple_myeloma#Pathophysiology Accessed on September, 20th 2015</ref> Multiple myeloma is the second most common blood cancer after [[non-Hodgkin's lymphoma]] and 14th most common cancer overall in United States.<ref name="Collins-2005">{{Cite journal  | last1 = Collins | first1 = CD. | title = Problems monitoring response in multiple myeloma. | journal = Cancer Imaging | volume = 5 Spec No A | issue =  | pages = S119-26 | month =  | year = 2005 | doi = 10.1102/1470-7330.2005.0033 | PMID = 16361127 }}</ref><ref name="seer">Seer stat fact sheet. National cancer institute (2015)http://seer.cancer.gov/statfacts/html/mulmy.html Accessed on September, 20th 2015</ref><ref name="wiki">Multiple myeloma. Wikipedia (2015)https://en.wikipedia.org/wiki/Multiple_myeloma#Pathophysiology Accessed on September, 20th 2015</ref> Males are more commonly affected with multiple myeloma than females; the male to female ratio is approximately 1.54 to 1.<ref name="wiki">Multiple myeloma. Wikipedia (2015)https://en.wikipedia.org/wiki/Multiple_myeloma#Pathophysiology Accessed on September, 20th 2015</ref><ref name="radio">Multiple myeloma. Radiopaedia (2015)http://radiopaedia.org/articles/multiple-myeloma-1 Accessed on September, 20th 2015</ref> Multiple myeloma usually affects individuals of the African American race. Asian individuals are less likely to develop multiple myeloma.<ref name="wiki">Multiple myeloma. Wikipedia (2015)https://en.wikipedia.org/wiki/Multiple_myeloma#Pathophysiology Accessed on September, 20th 2015</ref> The incidence of multiple myeloma increases with age.
+In 2012, the incidence of multiple myeloma was approximately 6.3 per 100,000 cases with a mortality rate of 3.3 per 100,000 cases in the United States. The prevalence of multiple myeloma was estimated to be 89,658 cases in 2012 in the United States. Multiple myeloma is the second most common blood cancer after [[non-Hodgkin's lymphoma]] and 14th most common [[cancer]] overall in United States. Males are more commonly affected with multiple myeloma than females; the male to female ratio is approximately 1.54 to 1. Multiple myeloma usually affects individuals of the African American race. Asian individuals are less likely to develop multiple myeloma. The incidence of multiple myeloma increases with age.
 ==Epidemiology and Demographics==
+===Incidence===
-=== Key Statistics ===
+*The age-standardized [[Incidence (epidemiology)|incidence]] rate of [[multiple myeloma]] worldwide is 1.5 per 100,000 persons per year.<ref name="pmid27604794">{{cite journal| author=Hong J, Lee JH| title=Recent advances in multiple myeloma: a Korean perspective. | journal=Korean J Intern Med | year= 2016 | volume= 31 | issue= 5 | pages= 820-34 | pmid=27604794 | doi=10.3904/kjim.2015.408 | pmc=5016289 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27604794  }} </ref><ref name="urlMyeloma - Cancer Stat Facts">{{cite web |url=https://seer.cancer.gov/statfacts/html/mulmy.html |title=Myeloma - Cancer Stat Facts |format= |work= |accessdate=}}</ref>
-{| class="wikitable"
+*According to age-adjusted rates based in 2011-2015, the [[Incidence (epidemiology)|incidence]] of [[multiple myeloma]] was approximately 6.7 per 100,000 individuals with a case-fatality rate of 3.3 per 100,000 in the United States.<ref name="PCN">Plasma cell neoplasm.National cancer institute (2015)http://www.cancer.gov/types/myeloma/hp/myeloma-treatment-pdq#cit/section_1.1 Accessed on September, 20th 2015</ref><ref name="urlMyeloma - Cancer Stat Facts">{{cite web |url=https://seer.cancer.gov/statfacts/html/mulmy.html |title=Myeloma - Cancer Stat Facts |format= |work= |accessdate=}}</ref>
-|+
+*In 2018, [[multiple myeloma]] will constitute approximately 1.8% of the estimated new [[cancer]] cases.<ref name="snap">A snapshot of myeloma. National cancer institute(2014)http://www.cancer.gov/research/progress/snapshots/myeloma Accessed on September, 20th 2015</ref><ref name="urlMyeloma - Cancer Stat Facts">{{cite web |url=https://seer.cancer.gov/statfacts/html/mulmy.html |title=Myeloma - Cancer Stat Facts |format= |work= |accessdate=}}</ref>
-!<big>Estimated New Cases in 2018</big>
+*In 2018, the estimated deaths caused by [[multiple myeloma]] will constitute 2.1% of all [[cancer]] [[mortality]] cases.<ref name="seer">Seer stat fact sheet. National cancer institute (2015)http://seer.cancer.gov/statfacts/html/mulmy.html Accessed on September, 20th 2015</ref><ref name="urlMyeloma - Cancer Stat Facts">{{cite web |url=https://seer.cancer.gov/statfacts/html/mulmy.html |title=Myeloma - Cancer Stat Facts |format= |work= |accessdate=}}</ref>
-!<big>30,770</big>
+*In 2018, approximately  30,770 people will be diagnosed with [[multiple myeloma]].<ref name="urlMyeloma - Cancer Stat Facts2">{{cite web |url=https://seer.cancer.gov/statfacts/html/mulmy.html |title=Myeloma - Cancer Stat Facts |format= |work= |accessdate=}}</ref>
+*In 2018, approximately 12,770 people die from [[multiple myeloma]].<ref name="urlMyeloma - Cancer Stat Facts">{{cite web |url=https://seer.cancer.gov/statfacts/html/mulmy.html |title=Myeloma - Cancer Stat Facts |format= |work= |accessdate=}}</ref>
+*According to 2013-2015 data, approximately 0.8% of all people will have a diagnosis of [[multiple myeloma]] at some point during their lifetime in [[United States|US]].<ref name="urlMyeloma - Cancer Stat Facts">{{cite web |url=https://seer.cancer.gov/statfacts/html/mulmy.html |title=Myeloma - Cancer Stat Facts |format= |work= |accessdate=}}</ref>
+*According to an estimation in 2015, there were 124,733 people with [[Multiple myeloma|myeloma]] living in the [[United States]].<ref name="urlMyeloma - Cancer Stat Facts">{{cite web |url=https://seer.cancer.gov/statfacts/html/mulmy.html |title=Myeloma - Cancer Stat Facts |format= |work= |accessdate=}}</ref>
+*[[Multiple myeloma]] is the second most common [[hematologic]] [[malignancy]], after [[non-Hodgkin lymphoma]].<ref name="pmid27604794">{{cite journal| author=Hong J, Lee JH| title=Recent advances in multiple myeloma: a Korean perspective. | journal=Korean J Intern Med | year= 2016 | volume= 31 | issue= 5 | pages= 820-34 | pmid=27604794 | doi=10.3904/kjim.2015.408 | pmc=5016289 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27604794  }} </ref>
+*Since 1975, the overall [[multiple myeloma]] incidence has increased nearly 1 percent annually.<ref name="snap">A snapshot of myeloma. National cancer institute(2014)http://www.cancer.gov/research/progress/snapshots/myeloma Accessed on September, 20th 2015</ref>
+*Solitary plasmacytoma accounts for approximately 5% of [[plasma cell]] [[neoplasms]].<ref name="pmid26464186">{{cite journal| author=Jia R, Xue L, Liang H, Gao K, Li J, Zhang Z| title=Surgery combined with radiotherapy for the treatment of solitary plasmacytoma of the rib: a case report and review of the literature. | journal=J Cardiothorac Surg | year= 2015 | volume= 10 | issue=  | pages= 125 | pmid=26464186 | doi=10.1186/s13019-015-0335-5 | pmc=4605096 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26464186  }} </ref>
+{| style="cellpadding=0; cellspacing= 0; width: 400px;"
+|-
+! colspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" + | Multiple Myeloma Epidemiology
+|-
+! align="center" style="background:#DCDCDC;" + |Estimated New Cases in 2018
+| align="center" style="background:#F5F5F5;" + |30,770
 |-
-!<big>% of All New Cancer Cases</big>
+! align="center" style="background:#DCDCDC;" + |% of All New Cancer Cases
-!<big>1.8%</big>
+| align="center" style="background:#F5F5F5;" + |1.8%
 |-
-!<big>Estimated Deaths in 2018</big>
+! align="center" style="background:#DCDCDC;" + |Estimated Deaths in 2018
-!<big>12,770</big>
+| align="center" style="background:#F5F5F5;" + |12,770
 |-
-!<big>% of All Cancer Deaths</big>
+! align="center" style="background:#DCDCDC;" + |% of All Cancer Deaths
-!<big>2.1%</big>
+| align="center" style="background:#F5F5F5;" + |2.1%
 |-
-!<big>5 Years Survival Rate</big>
+! align="center" style="background:#DCDCDC;" + |5 Years Survival Rate (2008-2014)
-!'''<big>50.7%</big>'''
+| align="center" style="background:#F5F5F5;" + |50.7%
-<small>2008-2014</small>
 |-
-| colspan="2" |Adopted from National Cancer Institute<ref name="urlMyeloma - Cancer Stat Facts">{{cite web |url=https://seer.cancer.gov/statfacts/html/mulmy.html |title=Myeloma - Cancer Stat Facts |format= |work= |accessdate=}}</ref>
+| colspan="2" align="left" style="background:#DCDCDC;" + |Adopted from National Cancer Institute<ref name="urlMyeloma - Cancer Stat Facts">{{cite web |url=https://seer.cancer.gov/statfacts/html/mulmy.html |title=Myeloma - Cancer Stat Facts |format= |work= |accessdate=}}</ref>
 |}
-{| class="wikitable"
+===Prevalence===
-|+
+*[[Multiple myeloma|Myeloma]] is the 14th leading cause of [[cancer]] death in the [[United States]].<ref name="seer">Seer stat fact sheet. National cancer institute (2015)http://seer.cancer.gov/statfacts/html/mulmy.html Accessed on September, 20th 2015</ref>
-! colspan="3" |'''New Cases per 100,000 Persons by Race/Ethnicity & Sex'''
+*According to an estimation in 2015, there were 124,733 people with [[Multiple myeloma|myeloma]] living in the [[United States]].<ref name="urlMyeloma - Cancer Stat Facts" />
+===Age===
+*The incidence of [[multiple myeloma]] increases with age, and the median age at diagnosis is 69 years.<ref name="urlMyeloma - Cancer Stat Facts" />
+{| style="cellpadding=0; cellspacing= 0; width: 400px;"
+|-
+! colspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" + |Percent of New Cases by Age Group
+|-
+! align="center" style="background:#4479BA; color: #FFFFFF;" + |Age
+! align="center" style="background:#4479BA; color: #FFFFFF;" + |Percent of New cases
 |-
-!Race
+! align="center" style="background:#DCDCDC;" + |<20
-!Female
+| align="center" style="background:#F5F5F5;" + |
-!Male
 |-
-|All Races
+! align="center" style="background:#DCDCDC;" + |20-34
-|5.3
+| align="center" style="background:#F5F5F5;" + |0.5%
-|8.4
 |-
-|White
+! align="center" style="background:#DCDCDC;" + |35-44
-|4.7
+| align="center" style="background:#F5F5F5;" + |2.8%
-|7.9
 |-
-|Black
+! align="center" style="background:#DCDCDC;" + |45-54
-|11.6
+| align="center" style="background:#F5F5F5;" + |10.9%
-|15.9
 |-
-|Asian / Pacific Islander
+! align="center" style="background:#DCDCDC;" + |55-64
-|3.1
+| align="center" style="background:#F5F5F5;" + |23.2%
-|4.9
 |-
-|American Indian / Alaska Native
+! align="center" style="background:#DCDCDC;" + |65-74
-|5.5
+| align="center" style="background:#F5F5F5;" + |29.8%
-|6.2
 |-
-|Hispanic
+! align="center" style="background:#DCDCDC;" + |75-84
-|5.0
+| align="center" style="background:#F5F5F5;" + |23.7%
-|7.6
 |-
-|Non-Hispanic
+! align="center" style="background:#DCDCDC;" + |>84
-|5.4
+| align="center" style="background:#F5F5F5;" + |9.0%
-|8.5
 |-
-| colspan="3" |Adopted from National Cancer Institute<ref name="urlMyeloma - Cancer Stat Facts" />
+| colspan="2" align="left" style="background:#DCDCDC;" + |Adopted from National Cancer Institute<ref name="urlMyeloma - Cancer Stat Facts" />
 |}
-{| class="wikitable"
+===Gender===
-|+
+*[[Males]] are more commonly affected with [[multiple myeloma]] than [[females]]. The [[male]] to [[female]] ratio is approximately 1.54 to 1.<ref name="radio">Multiple myeloma. Radiopaedia (2015)http://radiopaedia.org/articles/multiple-myeloma-1 Accessed on September, 20th 2015</ref>
-! colspan="2" |'''Percent of New Cases by Age Group'''
+===Race===
+*Among African Americans, [[multiple myeloma]] is one of the top 10 leading causes of [[cancer]] deaths.<ref name="seer">Seer stat fact sheet. National cancer institute (2015)http://seer.cancer.gov/statfacts/html/mulmy.html Accessed on September, 20th 2015</ref>
+*The incidence of [[multiple myeloma]] in the African American population is more than the European American population.
+*African Americans have a 2-fold higher age-standardized incidence rate of [[multiple myeloma]] than Caucasians. The incidence of [[multiple myeloma]] in African Americans is 9.6 per 100,000 persons. The incidence of Caucasians is 4.1 per 100,000 persons.<ref name="pmid27604794">{{cite journal| author=Hong J, Lee JH| title=Recent advances in multiple myeloma: a Korean perspective. | journal=Korean J Intern Med | year= 2016 | volume= 31 | issue= 5 | pages= 820-34 | pmid=27604794 | doi=10.3904/kjim.2015.408 | pmc=5016289 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27604794  }} </ref>
+{| style="cellpadding=0; cellspacing= 0; width: 400px;"
 |-
-!Age
+! colspan="3" align="center" style="background:#4479BA; color: #FFFFFF;" + |New Cases per 100,000 Persons by Race/Ethnicity & Sex
-!Percent of New cases
 |-
-|<sub><20</sub>
+! align="center" style="background:#4479BA; color: #FFFFFF;" + |Race
-|
+! align="center" style="background:#4479BA; color: #FFFFFF;" + |Female
+! align="center" style="background:#4479BA; color: #FFFFFF;" + |Male
 |-
-|20-34
+! align="center" style="background:#DCDCDC;" + |All Races
-|0.5%
+| align="center" style="background:#F5F5F5;" + |5.3
+| align="center" style="background:#F5F5F5;" + |8.4
 |-
-|35-44
+! align="center" style="background:#DCDCDC;" + |White
-|2.8%
+| align="center" style="background:#F5F5F5;" + |4.7
+| align="center" style="background:#F5F5F5;" + |7.9
 |-
-|45-54
+! align="center" style="background:#DCDCDC;" + |Black
-|10.9%
+| align="center" style="background:#F5F5F5;" + |11.6
+| align="center" style="background:#F5F5F5;" + |15.9
 |-
-|55-64
+! align="center" style="background:#DCDCDC;" + |Asian/Pacific Islander
-|23.2%
+| align="center" style="background:#F5F5F5;" + |3.1
+| align="center" style="background:#F5F5F5;" + |4.9
 |-
-|65-74
+! align="center" style="background:#DCDCDC;" + |American Indian/Alaska Native
-|29.8%
+| align="center" style="background:#F5F5F5;" + |5.5
+| align="center" style="background:#F5F5F5;" + |6.2
 |-
-|75-84
+! align="center" style="background:#DCDCDC;" + |Hispanic
-|23.7%
+| align="center" style="background:#F5F5F5;" + |5.0
+| align="center" style="background:#F5F5F5;" + |7.6
 |-
-|>84
+! align="center" style="background:#DCDCDC;" + |Non-Hispanic
-|9.0%
+| align="center" style="background:#F5F5F5;" + |5.4
+| align="center" style="background:#F5F5F5;" + |8.5
 |-
-| colspan="2" |Adopted from National Cancer Institute<ref name="urlMyeloma - Cancer Stat Facts" />
+| colspan="3" align="left" style="background:#DCDCDC;" + |Adopted from National Cancer Institute<ref name="urlMyeloma - Cancer Stat Facts" />
 |}
-===Incidence===
+==Gallery==
-*The age-standardized incidence rate of multiple myeloma worldwide is 1.5 per 100,000 persons per year.<ref name="pmid27604794">{{cite journal| author=Hong J, Lee JH| title=Recent advances in multiple myeloma: a Korean perspective. | journal=Korean J Intern Med | year= 2016 | volume= 31 | issue= 5 | pages= 820-34 | pmid=27604794 | doi=10.3904/kjim.2015.408 | pmc=5016289 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27604794  }} </ref><ref name="urlMyeloma - Cancer Stat Facts">{{cite web |url=https://seer.cancer.gov/statfacts/html/mulmy.html |title=Myeloma - Cancer Stat Facts |format= |work= |accessdate=}}</ref>
+[[File:Screenshot 2018-11-02 Myeloma - Cancer Stat Facts.png|thumb|none|500px|Adopted from National Cancer Institute]]
-*According to age-adjusted rates based in 2011-2015, the incidence of multiple myeloma was approximately 6.7 per 100,000 individuals with a case-fatality rate of 3.3 per 100,000 in the United States.<ref name="PCN">Plasma cell neoplasm.National cancer institute (2015)http://www.cancer.gov/types/myeloma/hp/myeloma-treatment-pdq#cit/section_1.1 Accessed on September, 20th 2015</ref><ref name="urlMyeloma - Cancer Stat Facts">{{cite web |url=https://seer.cancer.gov/statfacts/html/mulmy.html |title=Myeloma - Cancer Stat Facts |format= |work= |accessdate=}}</ref>
-*In 2018, multiple myeloma will constitute approximately 1.8% of the estimated new cancer cases.<ref name="snap">A snapshot of myeloma. National cancer institute(2014)http://www.cancer.gov/research/progress/snapshots/myeloma Accessed on September, 20th 2015</ref><ref name="urlMyeloma - Cancer Stat Facts">{{cite web |url=https://seer.cancer.gov/statfacts/html/mulmy.html |title=Myeloma - Cancer Stat Facts |format= |work= |accessdate=}}</ref>
-*In 2018, the estimated deaths caused by multiple myeloma will constitute 2.1% of all cancer mortality cases.<ref name="seer">Seer stat fact sheet. National cancer institute (2015)http://seer.cancer.gov/statfacts/html/mulmy.html Accessed on September, 20th 2015</ref><ref name="urlMyeloma - Cancer Stat Facts">{{cite web |url=https://seer.cancer.gov/statfacts/html/mulmy.html |title=Myeloma - Cancer Stat Facts |format= |work= |accessdate=}}</ref>
-*In 2018, approximately  30,770 people will be diagnosed with multiple myeloma.
-*In 2018, approximately 12,770 people die from multiple myeloma.<ref name="urlMyeloma - Cancer Stat Facts">{{cite web |url=https://seer.cancer.gov/statfacts/html/mulmy.html |title=Myeloma - Cancer Stat Facts |format= |work= |accessdate=}}</ref>
-*According to 2013-2015 data, approximately 0.8% of all people will have a diagnosis of multiple myeloma at some point during their lifetime in US.<ref name="urlMyeloma - Cancer Stat Facts">{{cite web |url=https://seer.cancer.gov/statfacts/html/mulmy.html |title=Myeloma - Cancer Stat Facts |format= |work= |accessdate=}}</ref>
-*According to an estimation in 2015, there were 124,733 people with myeloma living in the United States.<ref name="urlMyeloma - Cancer Stat Facts">{{cite web |url=https://seer.cancer.gov/statfacts/html/mulmy.html |title=Myeloma - Cancer Stat Facts |format= |work= |accessdate=}}</ref>
-*Multiple myeloma is the second most common hematologic malignancy, after [[non-Hodgkin lymphoma]].<ref name="pmid27604794">{{cite journal| author=Hong J, Lee JH| title=Recent advances in multiple myeloma: a Korean perspective. | journal=Korean J Intern Med | year= 2016 | volume= 31 | issue= 5 | pages= 820-34 | pmid=27604794 | doi=10.3904/kjim.2015.408 | pmc=5016289 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27604794  }} </ref>
-*Since 1975, the overall multiple myeloma incidence has increased nearly 1 percent annually.<ref name="snap">A snapshot of myeloma. National cancer institute(2014)http://www.cancer.gov/research/progress/snapshots/myeloma Accessed on September, 20th 2015</ref>
-*Solitary plasmacytoma accounts for approximately 5% of plasma cell neoplasms.<ref name="pmid26464186">{{cite journal| author=Jia R, Xue L, Liang H, Gao K, Li J, Zhang Z| title=Surgery combined with radiotherapy for the treatment of solitary plasmacytoma of the rib: a case report and review of the literature. | journal=J Cardiothorac Surg | year= 2015 | volume= 10 | issue=  | pages= 125 | pmid=26464186 | doi=10.1186/s13019-015-0335-5 | pmc=4605096 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26464186  }} </ref>
-===Prevalance===
-*Myeloma is the 14th leading cause of cancer death in the United States.<ref name="seer">Seer stat fact sheet. National cancer institute (2015)http://seer.cancer.gov/statfacts/html/mulmy.html Accessed on September, 20th 2015</ref>
-*In 2012, there were an estimated 89,658 people living with multiple myeloma in the United States.<ref name="seer">Seer stat fact sheet. National cancer institute (2015)http://seer.cancer.gov/statfacts/html/mulmy.html Accessed on September, 20th 2015</ref>
-===Age===
-*The incidence of multiple myeloma increases with age, and the median age at diagnosis is 65 to 70 years.<ref name="pmid27604794">{{cite journal| author=Hong J, Lee JH| title=Recent advances in multiple myeloma: a Korean perspective. | journal=Korean J Intern Med | year= 2016 | volume= 31 | issue= 5 | pages= 820-34 | pmid=27604794 | doi=10.3904/kjim.2015.408 | pmc=5016289 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27604794  }} </ref>
-===Gender===
-*Males are more commonly affected with multiple myeloma than females. The male to female ratio is approximately 1.54 to 1.<ref name="radio">Multiple myeloma. Radiopaedia (2015)http://radiopaedia.org/articles/multiple-myeloma-1 Accessed on September, 20th 2015</ref>
-*The incidence of solitary plasmacytoma in males to females is 2:1.<ref name="pmid26464186" />
-===Race===
+[[File:Screenshot 2018-11-02 Myeloma - Cancer Stat Facts(1).png||thumb|none|500px|]]
-*Among African Americans, multiple myeloma is one of the top 10 leading causes of cancer deaths.<ref name="seer">Seer stat fact sheet. National cancer institute (2015)http://seer.cancer.gov/statfacts/html/mulmy.html Accessed on September, 20th 2015</ref>
-*The incidence of multiple myeloma in the African American population is more than the European American population.
-*African Americans have a 2-fold higher age-standardized incidence rate of multiple myeloma than Caucasians.<ref name="pmid27604794">{{cite journal| author=Hong J, Lee JH| title=Recent advances in multiple myeloma: a Korean perspective. | journal=Korean J Intern Med | year= 2016 | volume= 31 | issue= 5 | pages= 820-34 | pmid=27604794 | doi=10.3904/kjim.2015.408 | pmc=5016289 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27604794  }} </ref> The incidence of multiple myeloma in African Americans is 9.6 per 100,000 persons. The incidence of Caucasians is 4.1 per 100,000 persons.<ref name="pmid27604794">{{cite journal| author=Hong J, Lee JH| title=Recent advances in multiple myeloma: a Korean perspective. | journal=Korean J Intern Med | year= 2016 | volume= 31 | issue= 5 | pages= 820-34 | pmid=27604794 | doi=10.3904/kjim.2015.408 | pmc=5016289 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27604794  }} </ref>
-==Gallery==
-[[File:Screenshot 2018-11-02 Myeloma - Cancer Stat Facts.png|thumb|Adopted from National Cancer Institute]]
-[[File:Screenshot 2018-11-02 Myeloma - Cancer Stat Facts(1).png|frame]]
 [[File:Multiple myeloma summary.png|thumb|none|500px|Multiple myeloma summary.<ref name="seer">Seer stat fact sheet. National cancer institute (2015)http://seer.cancer.gov/statfacts/html/mulmy.html Accessed on September, 20th 2015</ref>]]
 [[File:Percent of new cases by age group.png|thumb|none|500px|Percent of new cases by age group: multiple myeloma.<ref name="seer">Seer stat fact sheet. National cancer institute (2015)http://seer.cancer.gov/statfacts/html/mulmy.html Accessed on September, 20th 2015</ref>]]
 [[File:Number of new cases per race and gender.png|thumb|none|500px|Number of new cases per 100,000 persons by race/ethnicity & sex: multiple myeloma.<ref name="seer">Seer stat fact sheet. National cancer institute (2015)http://seer.cancer.gov/statfacts/html/mulmy.html Accessed on September, 20th 2015</ref>>]]
 [[File:Percent od deaths per age group Myeloma.png|thumb|none|500px|Percent of deaths per age group: multiple myeloma.<ref name="seer">Seer stat fact sheet. National cancer institute (2015)http://seer.cancer.gov/statfacts/html/mulmy.html Accessed on September, 20th 2015</ref>]]
 [[File:Number of Deaths per 100,000 Persons by RaceEthnicity & Sex Myeloma.png|thumb|none|500px|Number of deaths per 100,000 persons by race/ethnicity & sex multiple myeloma.<ref name="seer">Seer stat fact sheet. National cancer institute (2015)http://seer.cancer.gov/statfacts/html/mulmy.html Accessed on September, 20th 2015</ref>]]
 [[File:Percent of total cancer in the US.png|thumb|none|500px|Multiple myeloma percent of total new cancer csases in the United states.<ref name="seer">Seer stat fact sheet. National cancer institute (2015)http://seer.cancer.gov/statfacts/html/mulmy.html Accessed on September, 20th 2015</ref> ]]
 [[File:Multiple Myeloma 5 year survival rate.png|thumb|none|500px|Five year survival percentage.<ref name="seer">Seer stat fact sheet. National cancer institute (2015)http://seer.cancer.gov/statfacts/html/mulmy.html Accessed on September, 20th 2015</ref>]]
 [[File:New Cases, Deaths and 5-Year Relative Survival.png|thumb|none|500px|New cases, deaths, and 5-Year relative survival.<ref name="seer">Seer stat fact sheet. National cancer institute (2015)http://seer.cancer.gov/statfacts/html/mulmy.html Accessed on September, 20th 2015</ref>]]
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