Mucoepidermoid carcinoma medical therapy
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Badria Munir M.B.B.S.[2] , Maria Fernanda Villarreal, M.D. [3]
Overview
There is no medical treatment for mucoepidermoid carcinoma. Radiotherapy can be neoadjuvant treatment in some lesions (dependent on the tumor stage and size).
Medical Therapy
There is no medical treatment for mucoepidermoid carcinoma, However chemotherapy can be used in order to shrink down the tumor. Chemotherapy can be the option for palliative care. Following agents can be used: Radiotherapy can be neoadjuvant treatment in some lesions (dependent on the tumor stage and size).[1][1]
- Doxorubicin
- Mitoxantrone
- Vinorelbine,
- A new form of 5-fluorouracil called fluoropyrimidine
- Newer combinations with antimicrotubule agents such as cisplatin has shown some efficacy in malignant tumors.
- Paclitaxel has demonstrated moderate activity against mucoepidermoid tumors and adenocarcinomas but no effect adenoid cystic carcinoma.[2]
- Various biological agents under investigation are:
Radiotherapy
Radiotherapy can be used alone in non resecatable tumors as well as adjuvant therapy after surgery and chemotherapy. Various techniques using radiotherapy has demonstrated significant efficiacy in treatment of salivary gland tumors:
- Gamma-knife stereotactic radiosurgery
- Brachytherapy
- Iodine-125
- Proton based radiation
- Neutron therapy[3]
References
- ↑ 1.0 1.1 Evans HL (1984). "Mucoepidermoid carcinoma of salivary glands: a study of 69 cases with special attention to histologic grading". Am. J. Clin. Pathol. 81 (6): 696–701. PMID 6731349.
- ↑ Stenner M, Klussmann JP (March 2009). "Current update on established and novel biomarkers in salivary gland carcinoma pathology and the molecular pathways involved". Eur Arch Otorhinolaryngol. 266 (3): 333–41. doi:10.1007/s00405-008-0882-7. PMID 19052760.
- ↑ Park G, Lee SW (December 2018). "Postoperative radiotherapy for mucoepidermoid carcinoma of the major salivary glands: long-term results of a single-institution experience". Radiat Oncol J. 36 (4): 317–324. doi:10.3857/roj.2018.00409. PMID 30630270.