Monkeypox pathophysiology On the Web
American Roentgen Ray Society Images of Monkeypox pathophysiology
Monkeypox virus is a member of orthopoxvirus genus (family Poxviridae). The monkeypox virus genome consists of linear double-stranded DNA that multiplies in the cytoplasm of infected cell. Possible routes of transmission are animal-to-animal, animal-to-human, and human-to-human. Virus is transmitted via direct contact with body fluids or lesions of infection person or animal, direct contact with contaminated materials such as clothing, and via respiratory secretions. The role of vaginal fluids and semen in the transmission of the virus is still being investigated.
- Direct contact with bodily fluids or sores on the body of someone who has monkeypox
- Direct contact with contaminated materials such as clothing or linens
- Respiratory secretions when people have close, face-to-face contact
A study showed that monkeypox virus was isolated from a person’s semen 6 days after symptoms appeared. Other studies found that the DNA of the virus was present in semen weeks after infection. However, the role of semen or vaginal fluids in the transmission remains unclear.
- Monkeypox virus is a member of orthopoxvirus genus, which is a subdivision of Chordopoxvirinae that belongs to family Poxviridae.
- It is a linear double-stranded DNA virus that multiplies in the cytoplasm of infected cell.
- All the proteins required for viral DNA replication, transcription, virion assembly, and egress are encoded by the MPXV genome.
- The genes encoding for housekeeping functions are present in the central region of the genome, and the genes encoding the virus–host interactions are located in the termini region.
- The nucleotide sequence within the central region of the monkeypox virus genome is 96.3% identical with that of smallpox virus. Nonetheless, monkeypox virus is not the direct ancestor of smallpox virus and is unlikely to naturally acquire all properties of smallpox virus.
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