|
|
| Line 1: |
Line 1: |
| {{SI}}
| | #REDIRECT:[[Mixed connective tissue disease]] |
| | |
| {{WikiDoc Cardiology News}}
| |
| {{CMG}}
| |
| | |
| '''Associate Editor:''' {{CZ}}
| |
| | |
| | |
| | |
| ==Histopathological Findings==
| |
| | |
| There are no specific histologic findings that aid in the diagnosis of [[Mixed Connective Tissue Disorder]] as a separate autoimmune disease. For example, [[nephritis]] in [[MCTD]] is usually indistinguishable from [[lupus]] nephritis.
| |
| | |
| <div align="left">
| |
| <gallery heights="225" widths="225">
| |
| image:Fibrous Pericarditis in MCTD.jpg|Fibrous Pericarditis in MCTD
| |
| image:Cellular aggregates in perivascular space and adjacent myocardium.jpg|Cellular aggregates in perivascular space and adjacent myocardium
| |
| </gallery>
| |
| </div>
| |
| | |
| | |
| <div align="left">
| |
| <gallery heights="225" widths="225">
| |
| image:Cross Section of Intramural Coronary Artery.jpg|Cross Section of Intramural Coronary Artery
| |
| image:Small pulmonary artery in patient with MCTD and pulmonary hypertension.jpg|Small pulmonary artery in patient with MCTD and pulmnonary hypertension
| |
| </gallery>
| |
| </div>
| |
| | |
| ==Symptoms of MCTD==
| |
| | |
| ===Common symptoms===
| |
| | |
| *[[Raynaud’s phenomenon]]
| |
| | |
| *Swollen fingers or hands
| |
| | |
| ===Anti–U1 small nuclear RNP positive===
| |
| | |
| ===Mixed Connective Tissue Disorder Findings===
| |
| | |
| A.[[Systemic lupus erythematosus]]–like findings
| |
| | |
| *[[Polyarthritis]]
| |
| | |
| *[[Lymphadenopathy]]
| |
| | |
| *Facial [[erythema]]
| |
| | |
| *[[Pericarditis]] or [[pleuritis]]
| |
| | |
| *[[Leukopenia]] (<4,000/mm3) or thrombocytopenia (<100,000/mm3)
| |
| | |
| B.[[Scleroderma|Progressive Systemic Sclerosis]]–like findings
| |
| | |
| *[[Sclerodactyly]]
| |
| | |
| *[[Pulmonary fibrosis]], restrictive changes of the lung (forced vital capacity <80% of predicted), or reduced carbon monoxide diffusing capacity (<70% of predicted)
| |
| | |
| *Hypomotility or dilatation of esophagus
| |
| | |
| C.[[Polymyositis]]-like findings
| |
| | |
| *Muscle weakness
| |
| | |
| *Elevated serum level of muscle enzymes (creatine kinase)
| |
| | |
| *Myogenic pattern on electromyogram
| |
| | |
| ==Cardiac Involvement in MCTD==
| |
| | |
| Cardiovascular abnormalities associated with mixed connective tissue disease are rare. Presence of any of the complications listed below indicates unfavorable prognosis;
| |
| | |
| *Acute [[pericarditis]] and/or [[pericardial effusion]],
| |
| | |
| *[[Mitral valve prolapse]],
| |
| | |
| *Intimal hyperplasia of coronary arteries,
| |
| | |
| *Perivascular and myocardial leukocytic infiltrates,
| |
| | |
| *[[Pulmonary hypertension]].
| |
| | |
| *Coronary Artery Disease (although it is rarer, ACS may occur secondary to vascular changes and underlying CAD. The youngest patient with MCTD and ACS in literature was 18 years old)<ref>Jang J J, Olin J W, Fuster V. A teenager with mixed connective tissue disease presenting with an acute coronary syndrome. Vascular Medicine; 2004, Vol. 9 Issue 1, 31-34</ref>
| |
| | |
| <div align="left">
| |
| <gallery heights="225" widths="225">
| |
| image:Teenager before PCI.jpg|A teenager with MCTD presented as ACS before PCI
| |
| image:Teenager post PCI.jpg|A teenager with MCTD presented as ACS post PCI
| |
| </gallery>
| |
| </div>
| |
| | |
| ==References==
| |
| {{reflist|2}}
| |
| | |
|
| |
| | |
| | |
| [[Category:Cardiology]]
| |
| [[Category:Rheumatology]]
| |
| | |
| [[fr:Syndrome de Sharp]]
| |
| [[nl:Mixed connective tissue disease]]
| |
| [[ja:混合性結合組織病]]
| |
| [[sv:Mixed Connective Tissue Disease]]
| |
| | |
| {{WikiDoc Help Menu}}
| |
| {{WikiDoc Sources}}
| |