Mixed connective tissue disease laboratory tests
|
Mixed connective tissue disease Microchapters |
|
Differentiating Mixed connective tissue disease from other Diseases |
|---|
|
Diagnosis |
|
Treatment |
|
Case Studies |
|
Mixed connective tissue disease laboratory tests On the Web |
|
American Roentgen Ray Society Images of Mixed connective tissue disease laboratory tests |
|
Mixed connective tissue disease laboratory tests in the news |
|
Directions to Hospitals Treating Mixed connective tissue disease |
|
Risk calculators and risk factors for Mixed connective tissue disease laboratory tests |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shaghayegh Habibi, M.D.[2]
Overview
Laboratory findings consistent with the diagnosis of MCTD include antibodies against the U1RNP, positive rheumatoid factor (RF), elevated CRP levels, hypergammaglobulinemia, anemia, leucopenia, circulating immune complexes, and hypocomplementemia.
Laboratory Findings
- Laboratory findings consistent with the diagnosis of MCTD include:[1][2][3]
- Antibodies against the U1-ribonucleoprotein complex (anti U1RNP)
- Rheumatoid factor (RF) positive
- Complete blood count may shows:
- Circulating immune complexes
- Hypocomplementemia
- Elevated CRP levels[4]
- Hypergammaglobulinemia[5]
References
- ↑ Mimura Y, Ihn H, Jinnin M, Asano Y, Yamane K, Tamaki K (July 2006). "Rheumatoid factor isotypes in mixed connective tissue disease". Clin. Rheumatol. 25 (4): 572–4. doi:10.1007/s10067-005-0185-y. PMID 16391886.
- ↑ Ruiz Pombo M, Labrador Horrillo M, Selva O'Callaghan A (November 2004). "[Undifferentiated, overlapping and mixed connective tissue diseases]". Med Clin (Barc) (in Spanish; Castilian). 123 (18): 712–7. PMID 15563821.
- ↑ Latuśkiewicz-Potemska J, Zygmunt A, Biernacka-Zielińska M, Stańczyk J, Smolewska E (October 2013). "Mixed connective tissue disease presenting with progressive scleroderma symptoms in a 10-year-old girl". Postepy Dermatol Alergol. 30 (5): 329–36. doi:10.5114/pdia.2013.38365. PMC 3858664. PMID 24353496.
- ↑ Bakri Hassan A, Rönnelid J, Gunnarsson I, Karlsson G, Berg L, Lundberg I (October 1998). "Increased serum levels of immunoglobulins, C-reactive protein, type 1 and type 2 cytokines in patients with mixed connective tissue disease". J. Autoimmun. 11 (5): 503–8. doi:10.1006/jaut.1998.0236. PMID 9802936.
- ↑ Hämeenkorpi R, Ruuska P, Forsberg S, Tiilikainen R, Mäkitalo R, Hakala M (1993). "More evidence of distinctive features of mixed connective tissue disease". Scand. J. Rheumatol. 22 (2): 63–8. PMID 8480140.