Milroy's Disease
|
WikiDoc Resources for Milroy's Disease |
|
Articles |
|---|
|
Most recent articles on Milroy's Disease Most cited articles on Milroy's Disease |
|
Media |
|
Powerpoint slides on Milroy's Disease |
|
Evidence Based Medicine |
|
Clinical Trials |
|
Ongoing Trials on Milroy's Disease at Clinical Trials.gov Trial results on Milroy's Disease Clinical Trials on Milroy's Disease at Google
|
|
Guidelines / Policies / Govt |
|
US National Guidelines Clearinghouse on Milroy's Disease NICE Guidance on Milroy's Disease
|
|
Books |
|
News |
|
Commentary |
|
Definitions |
|
Patient Resources / Community |
|
Patient resources on Milroy's Disease Discussion groups on Milroy's Disease Patient Handouts on Milroy's Disease Directions to Hospitals Treating Milroy's Disease Risk calculators and risk factors for Milroy's Disease
|
|
Healthcare Provider Resources |
|
Causes & Risk Factors for Milroy's Disease |
|
Continuing Medical Education (CME) |
|
International |
|
|
|
Business |
|
Experimental / Informatics |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
| Milroy's disease | |
| ICD-10 | Q82.0 |
|---|---|
| ICD-9 | 757.0 |
| OMIM | 153100 |
| DiseasesDB | 8228 |
| eMedicine | med/1482 |
| MeSH | D008209 |
Milroy's disease is a familial disease characterised by lymphedema, commonly in the legs, caused by congenital abnormalities in the lymphatic system. Disruption of the normal drainage of lymph leads to fluid accumulation and hypertrophy of soft tissues.[1][2] It is also known as Milroy disease, Nonne-Milroy-Meige syndrome and hereditary lymphedema.[3]
It was named by Sir William Osler for William Milroy, an American physician, who described a case in 1892, though it was first described by Rudolf Virchow in 1863.[4][5]
Description
The defect in Milroy's disease is present from birth and symptoms are usually first experienced in childhood. The most common problem is one-sided leg swelling, unilateral edema, which is progressive and can affect both legs. Impaired intestinal lymphatics can cause steatorrhea due to impaired transport of chylomicrons. Defective lymphocyte circulation can cause lymphopenia and impaired cell-mediated immunity.
This disease is more common in women and an association with the gene FLT4 has been described.[6]
See also
External links
References
- ↑ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. p. 849. ISBN 0-7216-2921-0.
- ↑ David Lowell Strayer; Raphael Rubin (2007). Rubin's Pathology: Clinicopathologic Foundations of Medicine 5th Edition. Hagerstwon, MD: Lippincott Williams & Wilkins. ISBN 0-7817-9516-8.
- ↑ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 1-4160-2999-0.
- ↑ Template:WhoNamedIt
- ↑ W. F. Milroy. An undescribed variety of herditary edema. New York Medical Journal, 1892, 56: 505-508.
- ↑ Spiegel R, Ghalamkarpour A, Daniel-Spiegel E, Vikkula M, Shalev SA (2006). "Wide clinical spectrum in a family with hereditary lymphedema type I due to a novel missense mutation in VEGFR3". Journal of human genetics. 51 (10): 846–50. doi:10.1007/s10038-006-0031-3. PMID 16924388.
Template:Congenital malformations and deformations of integument