Microscopic polyangiitis laboratory findings: Difference between revisions
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Laboratory findings consistent with the diagnosis of Microscopic polyangiitis include, anti-neutrophil cytoplasmic antibody, elevated blood urea nitrogen, elevated serum creatinine, elevated erythrocyte sedimentation rate, proteinuria, hematuria, red cell casts and leukocytosis. | Laboratory findings consistent with the diagnosis of Microscopic polyangiitis include, anti-neutrophil cytoplasmic antibody, elevated blood urea nitrogen, elevated serum creatinine, elevated erythrocyte sedimentation rate, proteinuria, hematuria, red cell casts and leukocytosis. | ||
===Blood Work-up=== | ===Blood Work-up<ref name="pmid10088763">{{cite journal |vauthors=Guillevin L, Durand-Gasselin B, Cevallos R, Gayraud M, Lhote F, Callard P, Amouroux J, Casassus P, Jarrousse B |title=Microscopic polyangiitis: clinical and laboratory findings in eighty-five patients |journal=Arthritis Rheum. |volume=42 |issue=3 |pages=421–30 |date=March 1999 |pmid=10088763 |doi=10.1002/1529-0131(199904)42:3<421::AID-ANR5>3.0.CO;2-6 |url=}}</ref>=== | ||
* Anti-neutrophil cytoplasmic antibody test. | * Anti-neutrophil cytoplasmic antibody test. | ||
Revision as of 18:48, 23 April 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Ali Poyan Mehr, M.D. [2]Associate Editor(s)-in-Chief: Krzysztof Wierzbicki M.D. [3]
Overview
When suspecting a patient with microscopic polyanigitis an ANCA test should be an idle choice.Laboratory findings consistent with the diagnosis of Microscopic polyangiitis include, leukocytosis, elevated erythrocyte sedimentation rate, proteinuria, hematuria, red cell casts, elevated blood urea nitrogen, elevated serum creatinine, and anti-neutrophil cytoplasmic antibodies.
Laboratory Findings
Laboratory findings consistent with the diagnosis of Microscopic polyangiitis include, anti-neutrophil cytoplasmic antibody, elevated blood urea nitrogen, elevated serum creatinine, elevated erythrocyte sedimentation rate, proteinuria, hematuria, red cell casts and leukocytosis.
Blood Work-up[1]
- Anti-neutrophil cytoplasmic antibody test.
- Complete blood count.
- Serum creatinine.
- Blood urea nitrogen.
- leukocytosis.
Urianlysis
- Protienuria
- Hematuria
- Red cell casts
Biopsy
Biopsy of the involved skin, lung, renal, and nerve can be made to help establish a diagnosis of Microscopic polyangiitis.
- Skin biopsy is characterized by the presences of immunoglobulins and complement components.
- Renal biopsy is characterized as crescent formation with focal necrosis.
- Lung biopsy is characterized as alveolar capillaritis.
- Nerve biopsy is characterized by vascular necrosis of small and medium sized vessels.
References
- ↑ Guillevin L, Durand-Gasselin B, Cevallos R, Gayraud M, Lhote F, Callard P, Amouroux J, Casassus P, Jarrousse B (March 1999). "Microscopic polyangiitis: clinical and laboratory findings in eighty-five patients". Arthritis Rheum. 42 (3): 421–30. doi:10.1002/1529-0131(199904)42:3<421::AID-ANR5>3.0.CO;2-6. PMID 10088763.