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{{Infobox_Disease |
{{Microscopic polyangiitis}}
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{{CMG}} ; {{AE}} {{VKG}}{{Vbe}}
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  DiseasesDB    = 8193 |
  ICD10          = {{ICD10|M|31|7|m|30}} |
  ICD9          = |
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  OMIM          = |
  MedlinePlus    = |
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{{SI}}
{{CMG}}; '''Associate Editor-In-Chief:''' {{CZ}}


{{SK}} MPA
{{SK}} MPA
==Overview==
 
'''Microscopic polyangiitis (MPA) ''' is an ill-defined [[autoimmune disease]] characterized by pauci-immune, necrotizing, small-vessel [[vasculitis]] without clinical or pathological evidence of necrotizing granulomatous [[inflammation]]. Because many different organ systems may be involved, a wide range of symptoms are possible in MPA.
==[[Microscopic polyangiitis overview|Overview]]==
==Cause==
 
This condition, the clinical picture of which may include many features of systemic lupus erythematosis, has been reported to have been caused by [[antibiotics]] and also by certain [[infection]]s, though, as with many autoimmune diseases, the causes remain to a large extent unknown.
==[[Microscopic polyangiitis historical perspective|Historical Perspective]]==
 
==[[Microscopic polyangiitis classification|Classification]]==
 
==[[Microscopic polyangiitis pathophysiology|Pathophysiology]]==
 
==[[Microscopic polyangiitis causes|Causes]]==
 
==[[Microscopic polyangiitis differential diagnosis|Differentiating Any Disease from other Diseases]]==
 
==[[Microscopic polyangiitis epidemiology and demographics|Epidemiology and Demographics]]==
 
==[[Microscopic polyangiitis risk factors|Risk Factors]]==
 
==[[Microscopic polyangiitis screening|Screening]]==
 
==[[Microscopic polyangiitis natural history, complications and prognosis|Natural History, Complications and Prognosis]]==
 
==Diagnosis==
==Diagnosis==
Laboratory tests show an increased sedimentation rate, reduced red blood count, antineutrophil cytoplasmic antibodies (p-ANCA) directed against [MPO(a constituent of [[neutrophil]] granules), and [[protein]] and red blood cells in the [[urine]]
[[Microscopic polyangiitis history and symptoms|History and Symptoms]] | [[Microscopic polyangiitis physical examination|Physical Examination]] | [[Microscopic polyangiitis laboratory findings|Laboratory Findings]] | [[Microscopic polyangiitis electrocardiogram|Electrocardiogram]] | [[Microscopic polyangiitis chest x ray|Chest X Ray]] | [[Microscopic polyangiitis CT|CT]] | [[Microscopic polyangiitis MRI|MRI]] | [[Microscopic polyangiitis echocardiography or ultrasound|Echocardiography or Ultrasound]] | [[Microscopic polyangiitis other imaging findings|Other Imaging Findings]] | [[Microscopic polyangiitis other diagnostic studies|Other Diagnostic Studies]]


The test for [[anti-glomerular basement membrane antibody]] (GBM), which is positive in [[Goodpasture's syndrome]], is negative.
==Treatment==
==Treatment==
The customary treatment involves long term dosage of [[prednisone]], alternated or combined with [[cytotoxic]] drugs, such as [[cyclophosphamide]] or [[azathioprine]]. [[Plasmapheresis]] may also be indicated in the acute setting to remove ANCA antibodies.
[[Microscopic polyangiitis medical therapy|Medical Therapy]] | [[Microscopic polyangiitis surgery|Surgery]] | [[Microscopic polyangiitis primary prevention|Primary Prevention]] | [[Microscopic polyangiitis secondary prevention|Secondary Prevention]] | [[Microscopic polyangiitis cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Microscopic polyangiitis future or investigational therapies|Future or Investigational Therapies]]
 
==Case Studies==
[[Microscopic polyangiitis case study one|Case #1]]
 
[[Category:Projects]]
[[Category:Help]]
 
{{WH}}
{{WS}}
 
==References==
{{reflist|2}}


==Related Chapters==
==Related Chapters==
* [[ANCA-associated vasculitides]]
* [[ANCA-associated vasculitides]]
*[[Polyarteritis nodosa]]
* [[Polyarteritis nodosa]]


{{Diseases of the musculoskeletal system and connective tissue}}
{{Diseases of the musculoskeletal system and connective tissue}}

Latest revision as of 12:59, 23 July 2018

Microscopic polyangiitis Microchapters

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Overview

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Classification

Pathophysiology

Causes

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Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

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CT

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Other Diagnostic Studies

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2]Vindhya BellamKonda, M.B.B.S [3]

Synonyms and keywords: MPA

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Any Disease from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms | Physical Examination | Laboratory Findings | Electrocardiogram | Chest X Ray | CT | MRI | Echocardiography or Ultrasound | Other Imaging Findings | Other Diagnostic Studies

Treatment

Medical Therapy | Surgery | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies

Case Studies

Case #1

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References

Related Chapters

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