Metoprolol: Difference between revisions

Metoprolol
Clinical data
Trade names	Lopressor, Toprol-xl
AHFS/Drugs.com	Monograph
MedlinePlus	a682864
[[Regulation of therapeutic goods \|Template:Engvar data]]	US FDA: Metoprolol;
Pregnancy; category	AU: C ; US: C (Risk not ruled out) ; ;
Routes of; administration	Oral, IV
ATC code	C07AB02 (WHO) ;
Legal status
Legal status	In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	12%
Metabolism	Hepatic via CYP2D6, CYP3A4
Elimination half-life	3-7 hours
Excretion	Renal
Identifiers
	IUPAC name (RS)-1-(Isopropylamino)-3-[4-(2-methoxyethyl)phenoxy]propan-2-ol;
CAS Number	51384-51-1 ;
PubChem CID	4171;
IUPHAR/BPS	553;
DrugBank	DB00264 ;
ChemSpider	4027 ;
UNII	GEB06NHM23;
KEGG	D02358 ;
ChEBI	CHEBI:6904 ;
ChEMBL	ChEMBL13 ;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C15H25NO3
Molar mass	267.364 g/mol
3D model (JSmol)	Interactive image;
Melting point	120 °C (248 °F)
	SMILES O(c1ccc(cc1)CCOC)CC(O)CNC(C)C;
	InChI InChI=1S/C15H25NO3/c1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3/h4-7,12,14,16-17H,8-11H2,1-3H3 ; Key:IUBSYMUCCVWXPE-UHFFFAOYSA-N ;
(verify)

VisualWikitext

Revision as of 14:25, 26 March 2014

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms / Brand Names: Lopressor, Toprol XL, Toprolxl XL

Overview

Metoprolol is a competitive, β₁-selective (cardioselective) blocker used in treatment of angina pectoris, hypertension, arrhythmia, and migraine. Common adverse reactions include bradyarrhythmia, heart block, heart failure, hypotension, pruritus, rash, constipation, diarrhea, indigestion, nausea, dizziness, fatigue, headache, depression, dyspnea, and wheezing.

The active substance metoprolol is employed either as metoprolol succinate or as metoprolol tartrate (where 100 mg metoprolol tartrate corresponds to 95 mg metoprolol succinate). The tartrate is an immediate-release and the succinate is an extended-release formulation.^[1]

Prescribing Information

Metoprolol Succinate

Metoprolol Succinate/Hydrochlorothiazide

Metoprolol Tartrate

Metoprolol Tartrate/Arginine

[[Metoprolol tartrate/Hydrochlorothiazide|Metoprolol Tartrate/ydrochlorothiazide

References

↑ Cupp M (2009). "Alternatives for Metoprolol Succinate" (pdf). Pharmacist's Letter / Prescriber's Letter. 25 (250302).

[1] Cupp M (2009). "Alternatives for Metoprolol Succinate" (pdf). Pharmacist's Letter / Prescriber's Letter. 25 (250302).

[1]

@@ Line 17: / Line 17: @@
 ==Prescribing Information==
-===''Metoprolol Succinate''===
+===''[[Metoprolol succinate|Metoprolol Succinate]]''===
-=====Metoprolol succinate (metoprolol succinate) tablet, film coated, extended release=====
+===''[[Metoprolol succinate/Hydrochlorothiazide|Metoprolol Succinate/Hydrochlorothiazide]]''===
-=====Metoprolol succinate (metoprolol succinate) tablet, extended release=====
+===''[[Metoprolol tartrate|Metoprolol Tartrate]]''===
-=====[[Toprol XL tablet|Toprol XL (metoprolol succinate) tablet, extended release]]=====
+===''[[Metoprolol tartrate/Arginine|Metoprolol Tartrate/Arginine]]''===
-=====Toprolxl XL (metoprolol succinate) tablet, extended release=====
+===''[[Metoprolol tartrate/Hydrochlorothiazide|Metoprolol Tartrate/ydrochlorothiazide''===
-===''Metoprolol Succinate and Hydrochlorothiazide''===
-=====[[Dutoprol tablet|Dutoprol (metoprolol succinate and hydrochlorothiazide) tablet, film coated]]=====
-===''Metoprolol Tartrate''===
-=====[[Lopressor injection|Lopressor (metoprolol tartrate) injection, solution]]=====
-=====[[Lopressor tablet|Lopressor (metoprolol tartrate) tablet]]=====
-=====Metoprolol tartrate (metoprolol tartrate) injection, solution=====
-=====Metoprolol tartrate (metoprolol tartrate) tablet, film coated=====
-===''Metoprolol Tartrate and Arginine''===
-=====[[Hypertensolol kit|Hypertensolol (metoprolol tartrate, arginine) kit]]=====
-===''Metoprolol Tartrate and Hydrochlorothiazide''===
-=====[[Lopressor HCT tablet|Lopressor HCT (metoprolol tartrate and hydrochlorothiazide) tablet]]=====
-=====Metoprolol tartrate and hydrochlorothiazide (metoprolol tartrate and hydrochlorothiazide) tablet=====
 ==References==
 {{reflist|2}}
-{{beta blockers}}
-[[Category:Antianginals]]
-[[Category:Antiarrhythmic agents]]
-[[Category:Antihypertensive agents]]
-[[Category:Antimigraine drugs]]
-[[Category:Beta blockers]]
-[[Category:Cardiovascular Drugs]]