Metoprolol: Difference between revisions

Metoprolol
Clinical data
Trade names	Lopressor, Toprol-xl
AHFS/Drugs.com	Monograph
MedlinePlus	a682864
[[Regulation of therapeutic goods \|Template:Engvar data]]	US FDA: Metoprolol;
Pregnancy; category	AU: C ; US: C (Risk not ruled out) ; ;
Routes of; administration	Oral, IV
ATC code	C07AB02 (WHO) ;
Legal status
Legal status	In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	12%
Metabolism	Hepatic via CYP2D6, CYP3A4
Elimination half-life	3-7 hours
Excretion	Renal
Identifiers
	IUPAC name (RS)-1-(Isopropylamino)-3-[4-(2-methoxyethyl)phenoxy]propan-2-ol;
CAS Number	51384-51-1 ;
PubChem CID	4171;
IUPHAR/BPS	553;
DrugBank	DB00264 ;
ChemSpider	4027 ;
UNII	GEB06NHM23;
KEGG	D02358 ;
ChEBI	CHEBI:6904 ;
ChEMBL	ChEMBL13 ;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C15H25NO3
Molar mass	267.364 g/mol
3D model (JSmol)	Interactive image;
Melting point	120 °C (248 °F)
	SMILES O(c1ccc(cc1)CCOC)CC(O)CNC(C)C;
	InChI InChI=1S/C15H25NO3/c1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3/h4-7,12,14,16-17H,8-11H2,1-3H3 ; Key:IUBSYMUCCVWXPE-UHFFFAOYSA-N ;
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VisualWikitext

Revision as of 21:24, 12 March 2014

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Metoprolol is a selective β₁ receptor blocker used in treatment of several diseases of the cardiovascular system, especially hypertension. The active substance metoprolol is employed either as metoprolol succinate or as metoprolol tartrate (where 100 mg metoprolol tartrate corresponds to 95 mg metoprolol succinate). The tartrate is an immediate-release and the succinate is an extended-release formulation.^[1]

FDA Package Insert

Lopressor

Toprol XL

Taking Alcohol with Metoprolol

Alcohol-Metoprolol interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

References

↑ Cupp M (2009). "Alternatives for Metoprolol Succinate" (pdf). Pharmacist's Letter / Prescriber's Letter. 25 (250302).

[1] Cupp M (2009). "Alternatives for Metoprolol Succinate" (pdf). Pharmacist's Letter / Prescriber's Letter. 25 (250302).

[1]

@@ Line 5: / Line 5: @@
 ==Overview==
-'''Metoprolol''' is a selective [[beta blocker|β<sub>1</sub> receptor blocker]] used in treatment of several diseases of the cardiovascular system, especially [[hypertension]]. The active substance metoprolol is employed either as ''metoprolol [[succinic acid|succinate]]'' or as ''metoprolol [[tartrate]]'' (where 100&nbsp;mg metoprolol tartrate corresponds to 95&nbsp;mg metoprolol succinate). The tartrate is an immediate-release and the succinate is an extended-release [[Pharmaceutical formulation|formulation]].<ref>{{cite journal | author = Cupp M | title = Alternatives for Metoprolol Succinate | journal = Pharmacist's Letter / Prescriber's Letter | year = 2009 | volume = 25 | issue = 250302 | url = http://www.ncbop.org/PDF/MetoprololShortageMarch2009.pdf | format = pdf | accessdate = }}</ref>
+'''Metoprolol''' is a selective [[beta blocker|β<sub>1</sub> receptor blocker]] used in treatment of several diseases of the cardiovascular system, especially [[hypertension]]. The active substance metoprolol is employed either as ''metoprolol [[succinic acid|succinate]]'' or as ''metoprolol [[tartrate]]'' (where 100 mg metoprolol tartrate corresponds to 95 mg metoprolol succinate). The tartrate is an immediate-release and the succinate is an extended-release [[Pharmaceutical formulation|formulation]].<ref>{{cite journal | author = Cupp M | title = Alternatives for Metoprolol Succinate | journal = Pharmacist's Letter / Prescriber's Letter | year = 2009 | volume = 25 | issue = 250302 | url = http://www.ncbop.org/PDF/MetoprololShortageMarch2009.pdf | format = pdf | accessdate = }}</ref>
 ==Category==
@@ Line 11: / Line 11: @@
 Beta-blockers, Antimigraine drugs
-==[[Lopressor]]==
+==FDA Package Insert==
-==[[Toprol XL]]==
+===[[Lopressor]]===
+===[[Toprol XL]]===
 ==Taking Alcohol with Metoprolol==