Metoclopramide (oral)

{{DrugProjectFormSinglePage |authorTag=Kiran Singh, M.D. [1] |genericName=metoclopramide hydrochloride |aOrAn=a |indicationType=treatment |indication=symptoms due to [[gastroesophageal reflux] and diabetic gastroparesis |hasBlackBoxWarning=Yes |adverseReactions=headache, nausea, vomiting, fatigue, and somnolence |blackBoxWarningTitle=WARNING: TARDIVE DYSKINESIA |blackBoxWarningBody=* Treatment with metoclopramide can cause tardive dyskinesia, a serious movement disorder that is often irreversible. The risk of developing tardive dyskinesia increases with the duration of treatment and the total cumulative dose.

• Metoclopramide therapy should be discontinued in patients who develop signs or symptoms of tardive dyskinesia. There is no known treatment for tardive dyskinesia. In some patients, symptoms may lessen or resolve after metoclopramide treatment is stopped.

• Treatment with metoclopramide for longer than 12 weeks should be avoided in all but rare cases where therapeutic benefit is thought to outweigh the risk of developing tardive dyskinesia.

|fdaLIADAdult======Condition1=====

• Dosing Information

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|offLabelAdultGuideSupport======Condition1=====

• Developed by:

• Class of Recommendation:

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Condition2

There is limited information regarding Off-Label Guideline-Supported Use of Metoclopramide (oral) in adult patients.

|offLabelAdultNoGuideSupport======Condition1=====

• Dosing Information

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Condition2

There is limited information regarding Off-Label Non–Guideline-Supported Use of Metoclopramide (oral) in adult patients.

|fdaLIADPed======Condition1=====

• Dosing Information

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Condition2

There is limited information regarding FDA-Labeled Use of Metoclopramide (oral) in pediatric patients.

|offLabelPedGuideSupport======Condition1=====

• Developed by:

• Class of Recommendation:

• Strength of Evidence:

• Dosing Information

• Dosage

Condition2

There is limited information regarding Off-Label Guideline-Supported Use of Metoclopramide (oral) in pediatric patients.

|offLabelPedNoGuideSupport======Condition1=====

• Dosing Information

• Dosage

Condition2

There is limited information regarding Off-Label Non–Guideline-Supported Use of Metoclopramide (oral) in pediatric patients.

|contraindications=* Condition1

|warnings=* Description

Precautions

• Description

|clinicalTrials=There is limited information regarding Clinical Trial Experience of Metoclopramide (oral) in the drug label.

Miscellaneous

|postmarketing=There is limited information regarding Postmarketing Experience of Metoclopramide (oral) in the drug label.

Miscellaneous

|drugInteractions=* Drug

• Description

|useInPregnancyFDA=* Pregnancy Category |useInPregnancyAUS=* Australian Drug Evaluation Committee (ADEC) Pregnancy Category

There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Metoclopramide (oral) in women who are pregnant. |useInLaborDelivery=There is no FDA guidance on use of Metoclopramide (oral) during labor and delivery. |useInNursing=There is no FDA guidance on the use of Metoclopramide (oral) with respect to nursing mothers. |useInPed=There is no FDA guidance on the use of Metoclopramide (oral) with respect to pediatric patients. |useInGeri=There is no FDA guidance on the use of Metoclopramide (oral) with respect to geriatric patients. |useInGender=There is no FDA guidance on the use of Metoclopramide (oral) with respect to specific gender populations. |useInRace=There is no FDA guidance on the use of Metoclopramide (oral) with respect to specific racial populations. |useInRenalImpair=There is no FDA guidance on the use of Metoclopramide (oral) in patients with renal impairment. |useInHepaticImpair=There is no FDA guidance on the use of Metoclopramide (oral) in patients with hepatic impairment. |useInReproPotential=There is no FDA guidance on the use of Metoclopramide (oral) in women of reproductive potentials and males. |useInImmunocomp=There is no FDA guidance one the use of Metoclopramide (oral) in patients who are immunocompromised.

|administration=* Oral

• Intravenous

|monitoring=There is limited information regarding Monitoring of Metoclopramide (oral) in the drug label.

• Description

|IVCompat=There is limited information regarding IV Compatibility of Metoclopramide (oral) in the drug label.

|overdose====Acute Overdose===

Signs and Symptoms

• Description

Management

• Description

Chronic Overdose

There is limited information regarding Chronic Overdose of Metoclopramide (oral) in the drug label.

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File:Metoclopramide (oral)01.png

This image is provided by the National Library of Medicine.

|PD=There is limited information regarding Pharmacodynamics of Metoclopramide (oral) in the drug label.

|PK=There is limited information regarding Pharmacokinetics of Metoclopramide (oral) in the drug label.

|nonClinToxic=There is limited information regarding Nonclinical Toxicology of Metoclopramide (oral) in the drug label.

|clinicalStudies=There is limited information regarding Clinical Studies of Metoclopramide (oral) in the drug label.

|howSupplied=* |packLabel= |fdaPatientInfo=There is limited information regarding Patient Counseling Information of Metoclopramide (oral) in the drug label.

|alcohol=* Alcohol-Metoclopramide (oral) interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

|brandNames=* METOCLOPRAMIDE HYDROCHLORIDE® |lookAlike=* A® — B®

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