Methemoglobinemia history and symptoms: Difference between revisions
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==History and Symptoms== | ==History and Symptoms== | ||
*Depending on the levels of [[MetHb]] in the blood we can observe different symptoms as follows: [[MetHb]] 15 % | *Depending on the levels of [[MetHb]] in the blood we can observe different symptoms as follows: Patients with [[MetHb]] levels of up to 15% will present with skin and blood color (chocolate-brown) changes. Patients with [[MetHb]] levels above 15% will present with [[hypoxia]] and [[MetHb]] levels above 70% can lead to death.<ref>{{Rev Bras Anestesiol. 2008 Nov-Dec;58(6):651-64. Methemoglobinemia: from diagnosis to treatment. [Article in English, Portuguese] do Nascimento TS1, Pereira RO, de Mello HL, Costa J. pmid=19082413}}</ref> <ref>{{Toxicol Rev. 2003;22(1):13-27. | ||
Occupational methaemoglobinaemia. Mechanisms of production, features, diagnosis and management including the use of methylene blue. | Occupational methaemoglobinaemia. Mechanisms of production, features, diagnosis and management including the use of methylene blue. | ||
Bradberry SM1. pmid=14579544}}</ref> | Bradberry SM1. pmid=14579544}}</ref> | ||
Revision as of 14:10, 15 May 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Template:Aksiniya K. Stevasarova, M.D.
Overview
Congenital (Hereditary) Methemoglobinemia
There are three main congenital conditions that lead to methemoglobinemia:
1. Cytochrome b5 reductase deficiency and pyruvate kinase deficiency
3. Presence of abnormal hemoglobin (Hb M)
Acquired or Acute Methemoglobinemia
Most common cause include different oxidant drugs, toxins or chemicals
History and Symptoms
- Depending on the levels of MetHb in the blood we can observe different symptoms as follows: Patients with MetHb levels of up to 15% will present with skin and blood color (chocolate-brown) changes. Patients with MetHb levels above 15% will present with hypoxia and MetHb levels above 70% can lead to death.[1] [2]
- Cyanosis that is unresponsive to oxygen treatment is the main physical finding in people with methemoglobinemia, along with that the patient can present with dizziness, nausea and shortness of breath.
References
- ↑ {{Rev Bras Anestesiol. 2008 Nov-Dec;58(6):651-64. Methemoglobinemia: from diagnosis to treatment. [Article in English, Portuguese] do Nascimento TS1, Pereira RO, de Mello HL, Costa J. pmid=19082413}}
- ↑ {{Toxicol Rev. 2003;22(1):13-27. Occupational methaemoglobinaemia. Mechanisms of production, features, diagnosis and management including the use of methylene blue. Bradberry SM1. pmid=14579544}}