Methemoglobinemia causes: Difference between revisions

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'''1.''' '''Drug Induced'''  
'''1.''' '''Drug Induced'''  


*[[Anesthetics]]<ref>{{ J Emerg Med. 2018 Mar 5. pii: S0736-4679(18)30095-7. doi: 10.1016/j.jemermed.2018.01.039. [Epub ahead of print]
• [[Anesthetics]]<ref>{{ J Emerg Med. 2018 Mar 5. pii: S0736-4679(18)30095-7. doi: 10.1016/j.jemermed.2018.01.039. [Epub ahead of print]
Local Anesthetic-Induced Methemoglobinemia During Pregnancy: A Case Report and Evaluation of Treatment Options.
Local Anesthetic-Induced Methemoglobinemia During Pregnancy: A Case Report and Evaluation of Treatment Options.
Faust AC1, Guy E1, Baby N2, Ortegon A3.pmid=29519718}}</ref> like *[[benzocaine]]<ref>{{ Ann Pharmacother. 1994 May;28(5):643-9.
Faust AC1, Guy E1, Baby N2, Ortegon A3.pmid=29519718}}</ref> like [[benzocaine]]<ref>{{ Ann Pharmacother. 1994 May;28(5):643-9.
Benzocaine-induced methemoglobinemia: report of a severe reaction and review of the literature.
Benzocaine-induced methemoglobinemia: report of a severe reaction and review of the literature.
Rodriguez LF1, Smolik LM, Zbehlik AJ.pmid=8069004 }}</ref>, *[[lidocaine]]<ref>{{Drug Saf Case Rep. 2018 Apr 7;5(1):15. doi: 10.1007/s40800-018-0081-4.
Rodriguez LF1, Smolik LM, Zbehlik AJ.pmid=8069004 }}</ref>, [[lidocaine]]<ref>{{Drug Saf Case Rep. 2018 Apr 7;5(1):15. doi: 10.1007/s40800-018-0081-4.
Acquired Methemoglobinemia Associated with Topical Lidocaine Administration: A Case Report.
Acquired Methemoglobinemia Associated with Topical Lidocaine Administration: A Case Report.
Gay HC1,2, Amaral AP3. pmid=PMID: 29627919 }}</ref>, *[[prilocaine]]<ref>{{Isr Med Assoc J. 2014 Apr;16(4):250-4.
Gay HC1,2, Amaral AP3. pmid=PMID: 29627919 }}</ref>, [[prilocaine]]<ref>{{Isr Med Assoc J. 2014 Apr;16(4):250-4.
Methemoglobinemia induced by lidocaine-prilocaine cream.
Methemoglobinemia induced by lidocaine-prilocaine cream.
Shamriz O, Cohen-Glickman I, Reif S, Shteyer E.pmid=24834764}}</ref>
Shamriz O, Cohen-Glickman I, Reif S, Shteyer E.pmid=24834764}}</ref>
Line 44: Line 44:
• [[Nitroglycerin]]
• [[Nitroglycerin]]


• [[Antimalarial drugs]] like *[[Primaquine phosphate]] (in [[nicotinamide adenine dinucleotide]] ([[NADH]]) methemoglobin reductase deficient individuals)
• [[Antimalarial drugs]] like [[Primaquine phosphate]] (in [[nicotinamide adenine dinucleotide]] ([[NADH]]) methemoglobin reductase deficient individuals)


• [[Rasburicase]]  <ref>{{Curr Drug Saf. 2017;12(1):13-18. doi: 10.2174/1574886312666170111151246.
• [[Rasburicase]]  <ref>{{Curr Drug Saf. 2017;12(1):13-18. doi: 10.2174/1574886312666170111151246.

Revision as of 13:24, 15 May 2018

Methemoglobinemia Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Template:Aksiniya K. Stevasarova, M.D.

Overview

Methemoglobinemia may be caused by either congenital or acquired conditions.

Causes

Congenital (Hereditary) Methemoglobinemia

  • There are three main congenital conditions that lead to methemoglobinemia:

1. Cytochrome b5 reductase deficiency and pyruvate kinase deficiency

2. G6PD deficiency

3. Presence of abnormal hemoglobin (Hb M)


Acquired or Acute Methemoglobinemia

1. Drug Induced

Anesthetics[3] like benzocaine[4], lidocaine[5], prilocaine[6]

Methylene blue

Nitric oxide

Amyl Nitrate

Nitroglycerin

Antimalarial drugs like Primaquine phosphate (in nicotinamide adenine dinucleotide (NADH) methemoglobin reductase deficient individuals)

Rasburicase [7]

Sulfasalazine

Dapsone

Trimethoprim

Sulfonamides

Aniline dyes[8]

Metoclopramide

Chlorates and Bromates

2. Contaminated well water (in premature infants and infants younger than 4 months) [9] [10]

3. Solid foods (not well cooked vegetables high in nitrates in premature infants and infants younger than 4 months) [11] [12]

References

  1. Template:Med Toxicol. 1986 Jul-Aug;1(4):253-60. Drug- and chemical-induced methaemoglobinaemia. Clinical features and management. Hall AH, Kulig KW, Rumack BH.pmid=PMID: 3537620
  2. {{Rev Bras Anestesiol. 2008 Nov-Dec;58(6):651-64. Methemoglobinemia: from diagnosis to treatment. [Article in English, Portuguese] do Nascimento TS1, Pereira RO, de Mello HL, Costa J. pmid=19082413}}
  3. {{ J Emerg Med. 2018 Mar 5. pii: S0736-4679(18)30095-7. doi: 10.1016/j.jemermed.2018.01.039. [Epub ahead of print] Local Anesthetic-Induced Methemoglobinemia During Pregnancy: A Case Report and Evaluation of Treatment Options. Faust AC1, Guy E1, Baby N2, Ortegon A3.pmid=29519718}}
  4. {{ Ann Pharmacother. 1994 May;28(5):643-9. Benzocaine-induced methemoglobinemia: report of a severe reaction and review of the literature. Rodriguez LF1, Smolik LM, Zbehlik AJ.pmid=8069004 }}
  5. {{Drug Saf Case Rep. 2018 Apr 7;5(1):15. doi: 10.1007/s40800-018-0081-4. Acquired Methemoglobinemia Associated with Topical Lidocaine Administration: A Case Report. Gay HC1,2, Amaral AP3. pmid=PMID: 29627919 }}
  6. {{Isr Med Assoc J. 2014 Apr;16(4):250-4. Methemoglobinemia induced by lidocaine-prilocaine cream. Shamriz O, Cohen-Glickman I, Reif S, Shteyer E.pmid=24834764}}
  7. {{Curr Drug Saf. 2017;12(1):13-18. doi: 10.2174/1574886312666170111151246. Rasburicase-Induced Methemoglobinemia in a Patient with Glucose-6- Phosphate Dehydrogenase Deficiency. Khan M, Paul S, Farooq S, Oo TH, Ramshesh P, Jain N1. pmid=28078984}}
  8. {{Case Rep Emerg Med. 2015;2015:208732. doi: 10.1155/2015/208732. Epub 2015 Mar 12. P-chloroaniline poisoning causing methemoglobinemia: a case report and review of the literature. Messmer AS1, Nickel CH1, Bareiss D1. pmid=25861488 PMCID: PMC4377359 }}
  9. {{Eur J Emerg Med. 2003 Dec;10(4):326-30. A severe methaemoglobinemia induced by nitrates: a case report. Brunato F1, Garziera MG, Briguglio E. pmid=14676514 }}
  10. [www.epa.gov/dwstandardsregulations]
  11. [www.fda.gov/Drugs/DrugSafety/ucm250024.htm]
  12. [www.fda.gov/forconsumers/consumerupdates/ucm306062.htm]


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