Mesothelioma other diagnostic studies: Difference between revisions

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==Overview==
==Overview==
:* Antibodies to cytokeratin proteins are positive, differentiating these neoplasms from many sarcomas but not adenocarcinomas. 
Other diagnostic studies for mesothelioma include [[laparoscopy]], [[thoracoscopy]], [[pleuroscopy]], [[biopsy]], [[PET|position emission tomography scan]], and [[FISH|fluorescence in situ hybridization]].
:*The absence of staining with CEA or Leu-M1 differentiates them from adenocarcinomas. 
:*Recent evidence shows that Wilms’ Tumor Antigen 1 may help differentiate mesothelioma from adenocarcinoma.


==Other Diagnostic Studies==
==Other Diagnostic Studies==
===Laparoscopy, Thoracoscopy, and Pleuroscopy===
*[[Thoracoscopy]] or pleuroscopy may help in the [[diagnosis]] of [[mesothelioma]].<ref name="pmid19878170">{{cite journal| author=Alvarez JM, Hasani A, Segal A, Sterret G, Millward M, Nowak A et al.| title=Bilateral thoracoscopy, mediastinoscopy and laparoscopy, in addition to CT, MRI and PET imaging, are essential to correctly stage and treat patients with mesothelioma prior to trimodality therapy. | journal=ANZ J Surg | year= 2009 | volume= 79 | issue= 10 | pages= 734-8 | pmid=19878170 | doi=10.1111/j.1445-2197.2009.05060.x | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19878170  }} </ref><ref name="biopsyofmesothelioma1">Tests that examine the inside of the chest and abdomen are used to detect (find) and diagnose malignant mesothelioma. National cancer institute 2016. http://www.cancer.gov/types/mesothelioma/patient/mesothelioma-treatment-pdq. Accessed on February 15, 2016</ref><ref name="MRimesothelioma1">Radiographic findings of mesothelioma. Dr Bruno Di Muzio and A.Prof Frank Gaillard et al. Radiopaedia 2016. http://radiopaedia.org/articles/mesothelioma. Accessed on February 8, 2015</ref><ref name="pmid20139227">{{cite journal| author=Savic S, Franco N, Grilli B, Barascud Ade V, Herzog M, Bode B et al.| title=Fluorescence in situ hybridization in the definitive diagnosis of malignant mesothelioma in effusion cytology. | journal=Chest | year= 2010 | volume= 138 | issue= 1 | pages= 137-44 | pmid=20139227 | doi=10.1378/chest.09-1951 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20139227  }} </ref><ref name="pmid19878170">{{cite journal| author=Alvarez JM, Hasani A, Segal A, Sterret G, Millward M, Nowak A et al.| title=Bilateral thoracoscopy, mediastinoscopy and laparoscopy, in addition to CT, MRI and PET imaging, are essential to correctly stage and treat patients with mesothelioma prior to trimodality therapy. | journal=ANZ J Surg | year= 2009 | volume= 79 | issue= 10 | pages= 734-8 | pmid=19878170 | doi=10.1111/j.1445-2197.2009.05060.x | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19878170  }} </ref>
*[[Laparoscopy]] may be used to diagnose and treat selected cases of well-differentiated papillary [[mesothelioma]] associated with [[endometriosis|pelvic endometriosis]].<ref name="pmid20728825">{{cite journal| author=Nezhat FR, DeNoble SM, Brown DN, Shamshirsaz A, Hoehn D| title=Laparoscopic management of peritoneal mesothelioma associated with pelvic endometriosis. | journal=J Minim Invasive Gynecol | year= 2010 | volume= 17 | issue= 5 | pages= 646-50 | pmid=20728825 | doi=10.1016/j.jmig.2010.03.025 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20728825  }} </ref>
===Biopsy===
*[[Biopsy]] is helpful in the [[diagnosis]] of [[mesothelioma]].<ref name="biopsyofmesothelioma1">Tests that examine the inside of the chest and abdomen are used to detect (find) and diagnose malignant mesothelioma. National cancer institute 2016. http://www.cancer.gov/types/mesothelioma/patient/mesothelioma-treatment-pdq. Accessed on February 15, 2016</ref>
*Procedures performed for [[biopsy]] may include:<ref name="biopsyofmesothelioma1">Tests that examine the inside of the chest and abdomen are used to detect (find) and diagnose malignant mesothelioma. National cancer institute 2016. http://www.cancer.gov/types/mesothelioma/patient/mesothelioma-treatment-pdq. Accessed on February 15, 2016</ref>
:*[[Needle aspiration biopsy|Fine-needle (FNA) aspiration biopsy of the lung]]
:*[[Thoracoscopy]]
:*[[Thoracotomy]]
:*Peritoneoscopy
:*[[Biopsy|Open biopsy]]
===Position Emission Tomography===
===Position Emission Tomography===
*Positron emission tomography is becoming useful in two clinical settings:<ref name=MRimesothelioma1>Radiographic findings of mesothelioma. Dr Bruno Di Muzio and A.Prof Frank Gaillard et al. Radiopaedia 2016. http://radiopaedia.org/articles/mesothelioma. Accessed on February 8, 2015</ref>
*[[Positron emission tomography]] is becoming useful in two [[clinical]] settings:<ref name="MRimesothelioma1">Radiographic findings of mesothelioma. Dr Bruno Di Muzio and A.Prof Frank Gaillard et al. Radiopaedia 2016. http://radiopaedia.org/articles/mesothelioma. Accessed on February 8, 2015</ref>
:*Differentiating between benign and malignant asbestos-related pleural thickening
:*Differentiating between [[benign]] and [[malignant]] [[asbestos]]-related [[pleural]] thickening
:*Assessing for nodal metastases
:*Assessing for [[Nodal (protein)|nodal]] [[metastases]]
*In addition, there appears to be a correlation between the degree of [[Fludeoxyglucose F 18|FDG uptake]] and the biological aggressiveness of the tumor, which may help to guide treatment.<ref name=MRimesothelioma1>Radiographic findings of mesothelioma. Dr Bruno Di Muzio and A.Prof Frank Gaillard et al. Radiopaedia 2016. http://radiopaedia.org/articles/mesothelioma. Accessed on February 8, 2015</ref>
*In addition, there appears to be a correlation between the degree of [[Fludeoxyglucose F 18|FDG uptake]] and the biological aggressiveness of the [[tumor]], which may help to guide treatment.<ref name="MRimesothelioma1">Radiographic findings of mesothelioma. Dr Bruno Di Muzio and A.Prof Frank Gaillard et al. Radiopaedia 2016. http://radiopaedia.org/articles/mesothelioma. Accessed on February 8, 2015</ref>
 
===Fluorescence In Situ Hybridization (FISH)===
*[[FISH]] may be helpful in the [[diagnosis]] of [[mesothelioma]]. It helps in distinguishing [[malignant]] [[mesothelioma]] from reactive [[mesothelial]] [[cells]] in effusions.<ref name="pmid20139227">{{cite journal| author=Savic S, Franco N, Grilli B, Barascud Ade V, Herzog M, Bode B et al.| title=Fluorescence in situ hybridization in the definitive diagnosis of malignant mesothelioma in effusion cytology. | journal=Chest | year= 2010 | volume= 138 | issue= 1 | pages= 137-44 | pmid=20139227 | doi=10.1378/chest.09-1951 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20139227  }} </ref>
*Mutlitarget [[Fluorescence in situ hybridization|FISH]] [[Assays|assay]] may be used to detect [[chromosomal]] abberations ([[chromosome 3|chromosomes 3]], [[chromosome 7|7]], [[chromosome 17|17]], and [[chromosome 9|9p21]]).
*[[Fluorescence in situ hybridization|FISH]] technique may also be used to explore the alternative [[Mechanism (biology)|mechanism]] of [[tumor suppressor gene]] inactivation by [[methylation]] of ''[[p16]]'', ''p14'', and ''p15'' [[gene]] in the [[pathogenesis]] of mesothelioma.<ref name="pmid20139227">{{cite journal| author=Savic S, Franco N, Grilli B, Barascud Ade V, Herzog M, Bode B et al.| title=Fluorescence in situ hybridization in the definitive diagnosis of malignant mesothelioma in effusion cytology. | journal=Chest | year= 2010 | volume= 138 | issue= 1 | pages= 137-44 | pmid=20139227 | doi=10.1378/chest.09-1951 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20139227  }} </ref>


==References==
==References==
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[[Category:Up-To-Date]]
[[Category:Oncology]]
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Latest revision as of 15:49, 11 March 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Overview

Other diagnostic studies for mesothelioma include laparoscopy, thoracoscopy, pleuroscopy, biopsy, position emission tomography scan, and fluorescence in situ hybridization.

Other Diagnostic Studies

Laparoscopy, Thoracoscopy, and Pleuroscopy

Biopsy

Position Emission Tomography

  • In addition, there appears to be a correlation between the degree of FDG uptake and the biological aggressiveness of the tumor, which may help to guide treatment.[3]

Fluorescence In Situ Hybridization (FISH)

References

  1. 1.0 1.1 Alvarez JM, Hasani A, Segal A, Sterret G, Millward M, Nowak A; et al. (2009). "Bilateral thoracoscopy, mediastinoscopy and laparoscopy, in addition to CT, MRI and PET imaging, are essential to correctly stage and treat patients with mesothelioma prior to trimodality therapy". ANZ J Surg. 79 (10): 734–8. doi:10.1111/j.1445-2197.2009.05060.x. PMID 19878170.
  2. 2.0 2.1 2.2 Tests that examine the inside of the chest and abdomen are used to detect (find) and diagnose malignant mesothelioma. National cancer institute 2016. http://www.cancer.gov/types/mesothelioma/patient/mesothelioma-treatment-pdq. Accessed on February 15, 2016
  3. 3.0 3.1 3.2 Radiographic findings of mesothelioma. Dr Bruno Di Muzio and A.Prof Frank Gaillard et al. Radiopaedia 2016. http://radiopaedia.org/articles/mesothelioma. Accessed on February 8, 2015
  4. 4.0 4.1 4.2 Savic S, Franco N, Grilli B, Barascud Ade V, Herzog M, Bode B; et al. (2010). "Fluorescence in situ hybridization in the definitive diagnosis of malignant mesothelioma in effusion cytology". Chest. 138 (1): 137–44. doi:10.1378/chest.09-1951. PMID 20139227.
  5. Nezhat FR, DeNoble SM, Brown DN, Shamshirsaz A, Hoehn D (2010). "Laparoscopic management of peritoneal mesothelioma associated with pelvic endometriosis". J Minim Invasive Gynecol. 17 (5): 646–50. doi:10.1016/j.jmig.2010.03.025. PMID 20728825.

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