Membranoproliferative glomerulonephritis causes: Difference between revisions

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{{CMG}}{{APM}} {{AE}}{{OO}} Nazia Fuad, M.D
{{CMG}}{{APM}} {{AE}}{{OO}} Nazia Fuad, M.D
==Overview==
==Overview==
There are multiples causes for membranoproliferative glomerulonephritis, main are autoimmune diseases, mainly systemic lupus erythematosus (SLE),  Sjögren syndrome, rheumatoid arthritis, inherited complement deficiencies (esp C2 deficiency), scleroderma, Celiac disease.Chronic infections also play major role such as viral infections like hepatitis B, hepatitis C, and cryoglobulinemia type II. Bacterial infections such as endocarditis, infected ventriculoatrial (or jugular) shunt, multiple visceral abscesses, leprosy. Protozoal - malaria, schistosomiasis. Rare causes of MPGN include non-Hodgkin lymphoma, renal cell carcinoma, snake venom, splenorenal shunt surgery for portal hypertension , melanoma, alpha-1-antitrypsin deficiency, and cryoglobulinemic glomerulonephritis Idiopathic MPGN is a diagnosis of exclusion.
There are multiples causes for membranoproliferative glomerulonephritis.  Main are [[autoimmune diseases]], mainly [[systemic lupus erythematosus]] (SLE),  [[Sjögren's syndrome|Sjögren syndrome]], [[rheumatoid arthritis]], inherited complement deficiencies (esp C2 deficiency), [[scleroderma]], [[Celiac disease]] .Chronic infections also play major role such as viral infections like [[hepatitis B]], [[hepatitis C]], and [[cryoglobulinemia]] type II, bacterial infections such as [[endocarditis]], infected ventriculoatrial (or jugular) [[Shunt (medical)|shunt]], multiple [[Abscesses|visceral abscesses]], [[leprosy]]. [[Protozoal]] - [[malaria]], [[schistosomiasis]]. Rare causes of MPGN include [[non-Hodgkin lymphoma]], [[renal cell carcinoma]], [[Snake venoms|snake venom]], splenorenal shunt surgery for [[portal hypertension]] , [[melanoma]], [[Alpha 1-antitrypsin deficiency|alpha-1-antitrypsin]] deficiency, and [[Glomerulonephritis|cryoglobulinemic glomerulonephritis]] Idiopathic MPGN is a diagnosis of exclusion.


==Causes==
==Causes==
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Main causes of membranoproliferative pattern of injury are listed as follows:
Main causes of membranoproliferative pattern of injury are listed as follows:


* Immune complex–mediated disease
* [[Immune complex]]–mediated disease
:*Idiopathic forms of MPGN or of unknown association<ref>{{Cite journal|last=Fernando C. Fervenza, Sanjeev Sethi, and Richard J. Glassock|first=|date=2012|title=Idiopathic membranoproliferative glomerulonephritis: does it exist?|url=|journal=Nephrology Dialysis Transplantation ( NDT )|volume=|pages=|via=}}</ref>
:*[[Idiopathic]] forms of MPGN or of unknown association<ref>{{Cite journal|last=Fernando C. Fervenza, Sanjeev Sethi, and Richard J. Glassock|first=|date=2012|title=Idiopathic membranoproliferative glomerulonephritis: does it exist?|url=|journal=Nephrology Dialysis Transplantation ( NDT )|volume=|pages=|via=}}</ref>
:*:* MPGN type I
:*:* MPGN type I
:*:* MPGN type II or dense deposit disease and PLD
:*:* MPGN type II or dense deposit disease.
:*:* MPGN type III
:*:* MPGN type III
:* Autoimmune diseases<ref>{{Cite journal|last=H. Terence Cook and Matthew C. Pickering|first=|date=2014|title=Histopathology of MPGN and C3 glomerulopathies|url=|journal=NATURE REVIEWS NEPHROLOGY|volume=|pages=|via=}}</ref><ref>{{Cite journal|last=MICHELINE LEVY, MARIE-CLAIRE GUBLER, MIREILLE SICH, AGNES BEZIAU, AND RENE HABIB|first=|date=1978|title=lmmunopathology Glomerulonephritis of Membranoproliferative with Subendothelial Deposits|url=|journal=clinical immunology and immunopathology|volume=|pages=|via=}}</ref><ref>{{Cite journal|last=Mårten Segelmark, Thomas Hellmark|first=|date=2010|title=Autoimmune kidney diseases|url=|journal=Elsevier|volume=|pages=|via=}}</ref>
:* [[Autoimmune disease]]<nowiki/>s<ref>{{Cite journal|last=H. Terence Cook and Matthew C. Pickering|first=|date=2014|title=Histopathology of MPGN and C3 glomerulopathies|url=|journal=NATURE REVIEWS NEPHROLOGY|volume=|pages=|via=}}</ref><ref>{{Cite journal|last=MICHELINE LEVY, MARIE-CLAIRE GUBLER, MIREILLE SICH, AGNES BEZIAU, AND RENE HABIB|first=|date=1978|title=lmmunopathology Glomerulonephritis of Membranoproliferative with Subendothelial Deposits|url=|journal=clinical immunology and immunopathology|volume=|pages=|via=}}</ref><ref>{{Cite journal|last=Mårten Segelmark, Thomas Hellmark|first=|date=2010|title=Autoimmune kidney diseases|url=|journal=Elsevier|volume=|pages=|via=}}</ref>
:*:* Systemic lupus erythematosus (SLE)
:*:* [[Systemic lupus erythematosus]] (SLE)
:*:* Sjögren syndrome
:*:* [[Sjögren's syndrome|Sjögren syndrome]]
:*:* Rheumatoid arthritis
:*:* [[Rheumatoid arthritis]]
:*:* Inherited complement deficiencies, in particular, C2 deficiency
:*:* Inherited complement deficiencies, in particular, C2 deficiency
:*:* Scleroderma
:*:* [[Scleroderma]]
:*:* Celiac disease
:*:* [[Celiac disease]]
:* Chronic infections
:* Chronic infections
:*:* Viral - Hepatitis B, hepatitis C, and cryoglobulinemia type II
:*:* [[Viral Hepatitis|Viral]] - [[Hepatitis B]], [[hepatitis C]], and [[Cryoglobulinemia|cryoglobulinemia type II]]
:*:* Bacterial - Endocarditis, infected ventriculoatrial (or jugular) shunt, multiple visceral abscesses, leprosy
:*:* [[Bacterial]] - [[Endocarditis]], infected ventriculoatrial (or jugular) shunt, multiple visceral [[Abscess|abscesses]], [[leprosy]]
:*:* Protozoal - Malaria, schistosomiasis
:*:* [[Protozoal]] - [[Malaria]][[Schistosomiasis|, schistosomiasis]]
:*:* Other infections - Mycoplasma, Lyme Disease<ref>{{Cite journal|last=Dimitrios Kirmizis, MD, Georgios Efstratiadis, MD, Dominiki Economidou, MD, Evdoxia Diza-Mataftsi, MD, Maria Leontsini, MD, and Dimitrios Memmos, MD|first=|date=2004|title=MPGN Secondary to Lyme Disease|url=|journal=American Journal of Kidney Diseases|volume=43|pages=|via=}}</ref>  
:*:* Other infections - [[Mycoplasma]], [[Lyme disease|Lyme Disease]]<ref>{{Cite journal|last=Dimitrios Kirmizis, MD, Georgios Efstratiadis, MD, Dominiki Economidou, MD, Evdoxia Diza-Mataftsi, MD, Maria Leontsini, MD, and Dimitrios Memmos, MD|first=|date=2004|title=MPGN Secondary to Lyme Disease|url=|journal=American Journal of Kidney Diseases|volume=43|pages=|via=}}</ref>  
:* Miscellaneous - Chronic liver disease (cirrhosis and alpha1-antitrypsin deficiency)
:* Miscellaneous - [[Chronic liver disease]] ([[cirrhosis]] and [[Alpha 1-antitrypsin deficiency|alpha1-antitrypsin deficiency]])
* Chronic and recovered thrombotic microangiopathies
* Chronic and recovered [[thrombotic microangiopathies]]
:* Healing phase of hemolytic uremic syndrome and/or thrombotic thrombocytopenic purpura
:* Healing phase of [[Hemolytic-uremic syndrome|hemolytic uremic syndrome]] and/or [[thrombotic thrombocytopenic purpura]]
:* Syndromes of circulating antiphospholipid (anticardiolipin) antibodies
:* Syndromes of circulating [[Antiphospholipid antibodies|antiphospholipid (anticardiolipin) antibodies]]
:* Radiation nephritis
:* [[Radiation]] [[nephritis]]
:* Nephropathy associated with bone marrow transplantation
:* [[Nephropathy]] associated with [[bone marrow transplantation]]
:* Sickle cell anemia and polycythemia
:* [[Sickle cell anemia]] and [[polycythemia]]
:* Transplant glomerulopathy
:* Transplant [[glomerulopathy]]
* Paraprotein deposition diseases
* [[Paraprotein]] deposition diseases
:* Glomerulonephropathies associated with cryoglobulinemia type I
:* Glomerulonephropathies associated with [[cryoglobulinemia]] type I
:* Waldenström macroglobulinemia
:* Waldenström [[macroglobulinemia]]
:* Immunotactoid glomerulopathy
:* Immunotactoid glomerulopathy
:* Immunoglobulin light chain or heavy chain deposition diseases
:* [[Immunoglobulin]] light chain or heavy chain deposition diseases
:* Fibrillary glomerulonephritis
:* Fibrillary [[glomerulonephritis]]
* Malignant neoplasms
* [[Malignant]] [[Neoplasm|neoplasms]]
:* Lymphoma
:* [[Lymphoma]]
:* Leukemia
:* [[Leukemia]]
:* Carcinoma
:* [[Carcinoma]]


==References==
==References==

Revision as of 18:10, 25 July 2018


Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Ali Poyan Mehr, M.D. [2] Associate Editor(s)-in-Chief: Olufunmilola Olubukola M.D.[3] Nazia Fuad, M.D

Overview

There are multiples causes for membranoproliferative glomerulonephritis. Main are autoimmune diseases, mainly systemic lupus erythematosus (SLE), Sjögren syndrome, rheumatoid arthritis, inherited complement deficiencies (esp C2 deficiency), scleroderma, Celiac disease .Chronic infections also play major role such as viral infections like hepatitis B, hepatitis C, and cryoglobulinemia type II, bacterial infections such as endocarditis, infected ventriculoatrial (or jugular) shunt, multiple visceral abscesses, leprosy. Protozoal - malaria, schistosomiasis. Rare causes of MPGN include non-Hodgkin lymphoma, renal cell carcinoma, snake venom, splenorenal shunt surgery for portal hypertension , melanoma, alpha-1-antitrypsin deficiency, and cryoglobulinemic glomerulonephritis Idiopathic MPGN is a diagnosis of exclusion.

Causes

Main causes of membranoproliferative pattern of injury are listed as follows:

References

  1. ↑ Fernando C. Fervenza, Sanjeev Sethi, and Richard J. Glassock (2012). "Idiopathic membranoproliferative glomerulonephritis: does it exist?". Nephrology Dialysis Transplantation ( NDT ).
  2. ↑ H. Terence Cook and Matthew C. Pickering (2014). "Histopathology of MPGN and C3 glomerulopathies". NATURE REVIEWS NEPHROLOGY.
  3. ↑ MICHELINE LEVY, MARIE-CLAIRE GUBLER, MIREILLE SICH, AGNES BEZIAU, AND RENE HABIB (1978). "lmmunopathology Glomerulonephritis of Membranoproliferative with Subendothelial Deposits". clinical immunology and immunopathology.
  4. ↑ Mårten Segelmark, Thomas Hellmark (2010). "Autoimmune kidney diseases". Elsevier.
  5. ↑ Dimitrios Kirmizis, MD, Georgios Efstratiadis, MD, Dominiki Economidou, MD, Evdoxia Diza-Mataftsi, MD, Maria Leontsini, MD, and Dimitrios Memmos, MD (2004). "MPGN Secondary to Lyme Disease". American Journal of Kidney Diseases. 43.

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