View source for Medium-sized vessel vasculitis with headache, fever, weight loss, arthralgia, claudication, bruit, and hypertension

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{{CMG}}; {{AE}} {{EG}}

<span style="font-size:85%">'''Abbreviations:'''
ABG= [[Arterial blood gas]], ANA= [[Antinuclear antibody]], ANP= [[Atrial natriuretic peptide]], ASO= [[Antistreptolysin O|Antistreptolysin O antibody]], BNP= [[Brain natriuretic peptide]], CBC= [[Complete blood count]], COPD= [[Chronic obstructive pulmonary disease]], CRP= [[C-reactive protein]], CT= [[Computed tomography]], CXR= [[Chest X-ray]], DVT= [[Deep vein thrombosis]], ESR= [[Erythrocyte sedimentation rate]], HRCT= [[High Resolution CT]], IgE= [[Immunoglobulin E]], LDH= [[Lactate dehydrogenase]], PCWP= [[Pulmonary capillary wedge pressure]], PCR= [[Polymerase chain reaction]], PFT= [[Pulmonary function test]].</span>
<small>
{| style="border: 0px; font-size: 90%; margin: 3px;" align="center"
! colspan="3" rowspan="4" style="background:#4479BA; color: #FFFFFF;" align="center" |Diseases
| colspan="8" rowspan="1" style="background:#4479BA; color: #FFFFFF;" align="center" |'''Clinical manifestations'''
! colspan="9" rowspan="2" style="background:#4479BA; color: #FFFFFF;" align="center" |Para-clinical findings
| colspan="1" rowspan="4" style="background:#4479BA; color: #FFFFFF;" align="center" |'''Gold standard'''
! rowspan="4" style="background:#4479BA; color: #FFFFFF;" align="center" |Additional findings
|-
| colspan="5" rowspan="2" style="background:#4479BA; color: #FFFFFF;" align="center" |'''Symptoms'''
! colspan="3" rowspan="2" style="background:#4479BA; color: #FFFFFF;" align="center" | Physical examination
|-
! colspan="4" style="background:#4479BA; color: #FFFFFF;" align="center" |Lab Findings
! colspan="4" style="background:#4479BA; color: #FFFFFF;" align="center" |Imaging
! rowspan="2" style="background:#4479BA; color: #FFFFFF;" align="center" |Histopathology
|-
! style="background:#4479BA; color: #FFFFFF;" align="center" |Headache
! colspan="1" rowspan="1" style="background:#4479BA; color: #FFFFFF;" align="center" | Fever 
! style="background:#4479BA; color: #FFFFFF;" align="center" |Weight loss
! style="background:#4479BA; color: #FFFFFF;" align="center" |Arthralgia
! style="background:#4479BA; color: #FFFFFF;" align="center" |Claudication
! style="background:#4479BA; color: #FFFFFF;" align="center" |Bruit
! colspan="1" rowspan="1" style="background:#4479BA; color: #FFFFFF;" align="center" |HTN
! style="background:#4479BA; color: #FFFFFF;" align="center" |Focal neurological disorder
! style="background:#4479BA; color: #FFFFFF;" align="center" |Biomarker
! style="background:#4479BA; color: #FFFFFF;" align="center" |CBC
! style="background:#4479BA; color: #FFFFFF;" align="center" |ESR
! style="background:#4479BA; color: #FFFFFF;" align="center" |Other
! style="background:#4479BA; color: #FFFFFF;" align="center" |CT scan
! style="background:#4479BA; color: #FFFFFF;" align="center" |Angiography
! style="background:#4479BA; color: #FFFFFF;" align="center" |Ultrasound/ Echocardiography
! style="background:#4479BA; color: #FFFFFF;" align="center" |Other
|-
! rowspan="2" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Medium-Vessel Vasculitis
! colspan="2" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Polyarteritis nodosa]]<ref name="pmid25770638">{{cite journal| author=Howard T, Ahmad K, Swanson JA, Misra S| title=Polyarteritis nodosa. | journal=Tech Vasc Interv Radiol | year= 2014 | volume= 17 | issue= 4 | pages= 247-51 | pmid=25770638 | doi=10.1053/j.tvir.2014.11.005 | pmc=4363102 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25770638  }}</ref>
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[LAMP2|LAMP-2 protein autoantibodies]] 
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]], [[Normochromic anemia]], [[Thrombocytosis]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑ [[Creatinine|Cr]] or [[Blood urea nitrogen|BUN]], 
↑ [[ALT]] or [[AST]], [[Proteinuria]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Focal regions of [[infarction]] or [[hemorrhage]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Multiple [[Aneurysm|microaneurysms]],  [[Hemorrhage]] due to focal [[rupture]], [[Occlusion]] 
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Aneurysms]] and [[renal]] [[arteriovenous fistula]] in [[Doppler sonography|color Doppler sonography]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Necrotizing]] [[inflammatory]] lesions
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Angiography]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Sudden [[weight loss]], [[Abdominal pain]]
|-
! colspan="2" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Hepatitis B virus]]-associated [[polyarteritis nodosa]]<ref name="pmid25755502">{{cite journal |vauthors=Sharma A, Sharma K |title=Hepatotropic viral infection associated systemic vasculitides-hepatitis B virus associated polyarteritis nodosa and hepatitis C virus associated cryoglobulinemic vasculitis |journal=J Clin Exp Hepatol |volume=3 |issue=3 |pages=204–12 |date=September 2013 |pmid=25755502 |pmc=4216827 |doi=10.1016/j.jceh.2013.06.001 |url=}}</ref>
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hepatitis B surface antigen|HBsAg]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]], [[Normochromic anemia]], [[Thrombocytosis]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑ [[ALT]] or [[AST]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Focal regions of [[infarction]] or [[hemorrhage]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Aneurysms|Microaneurysms]] in [[mesenteric artery]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Aneurysms]] and [[renal]] [[arteriovenous fistula]] in [[Doppler sonography|color Doppler sonography]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Necrotizing]] [[inflammatory]] lesions
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Angiography]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Peripheral neuropathy]], [[Livedo reticularis]]
|-
|}
</small>
==References==
{{Reflist|2}}
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[[Category:Medicine]]
[[Category:Up-To-Date]]
[[Category:Rheumatology]]