Mast cell tumor laboratory findings: Difference between revisions
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==Overview== | ==Overview== | ||
==Laboratory Findings== | ==Laboratory Findings== | ||
{{familytree/start |summary=Skin lesions or suggestive clinical}} | |||
{{familytree |boxstyle=background: #DCDCDC; | | | | | | | | | | A01 |A01=<div style="width: 12em; padding:0.2em;">'''Skin lesions or suggestive clinical'''</div>}} | |||
{{familytree |boxstyle=background: #DCDCDC; | | | | | | | | | | A01 |A01=<div style="width: 12em; padding:0.2em;">'''Serum Tryptase''' | |||
'''Complete blood count''' | |||
'''Complete metabolic panel'''</div>}} | |||
{{familytree |boxstyle=background: #DCDCDC; | | | | | | |,|-|-|-|^|-|-|-|.| }} | |||
{{familytree |boxstyle=background: #DCDCDC; | | | | | | B01 | | | | | | B02 |B01=<div style="width: 9em; padding:0.2em;">Normal complete blood count | |||
Serum tryptase ≤ 100ng/ml | |||
</div>|B02=<div style="width: 9em; padding:0.2em;">Abnormal complete blood cell count | |||
Serum tryptase > 100 ng/ml</div>}} | |||
{{familytree |boxstyle=background: #DCDCDC; | | | | |,|-|^|-|.| | | |,|-|^|-|.|}} | |||
{{familytree |boxstyle=background: #DCDCDC; | | | | C01 | | C02 | | C03 | | C04|C01=<div style="width: 9em; padding:0.2em;">'''Simple hyperplasia with cellular atypia ''' | |||
</div>|C02=<div style="width: 9em; padding:0.2em;">'''Simple hyperplasia without cellular atypia'''</div>|C03=<div style="width: 9em; padding:0.2em;">'''Complex hyperplasia with cellular atypia''' | |||
</div>|C04=<div style="width: 9em; padding:0.2em;">'''Complex hyperplasia without cellular atypia ''' | |||
</div>|}} | |||
{{familytree/end}} | |||
The diagnosis of systemic mastocytosis is established by demonstrating mast cell infiltration in an involved tissue, particularly the bone marrow, using special staining techniques or flow cytometry, but the measurement of serum tryptase is a good screening test, since almost all patients with systemic mastocytosis have serum tryptase levels exceeding 20 ng/mL.<ref name="KoenigMorel2008">{{cite journal|last1=Koenig|first1=Martial|last2=Morel|first2=Jérôme|last3=Reynaud|first3=Jacqueline|last4=Varvat|first4=Cécile|last5=Cathébras|first5=Pascal|title=An unusual cause of spontaneous bleeding in the intensive care unit – mastocytosis: a case report|journal=Cases Journal|volume=1|issue=1|year=2008|pages=100|issn=1757-1626|doi=10.1186/1757-1626-1-100}}</ref> | |||
*[[Complete blood count]] | *[[Complete blood count]] | ||
:*[[Eosinophilia]] | :*[[Eosinophilia]] | ||
:*[[Thrombocytopenia]] | :*[[Thrombocytopenia]] | ||
*[[Tryptase]] levels | *[[Tryptase]] levels<ref name="OzdemirDagdelen2010">{{cite journal|last1=Ozdemir|first1=Didem|last2=Dagdelen|first2=Selcuk|last3=Erbas|first3=Tomris|last4=Agbaht|first4=Kemal|last5=Serefhanoglu|first5=Songul|last6=Aksu|first6=Salih|last7=Ersoy-Evans|first7=Sibel|title=Hypotension, Syncope, and Fever in Systemic Mastocytosis without Skin Infiltration and Rapid Response to Corticosteroid and Cyclosporin: A Case Report|journal=Case Reports in Medicine|volume=2010|year=2010|pages=1–4|issn=1687-9627|doi=10.1155/2010/782595}}</ref> | ||
:*Tryptase which is stored almost exclusively within the secretory granules of mast cells is the most widely used marker of mastocytosis. | :*Tryptase which is stored almost exclusively within the secretory granules of mast cells is the most widely used marker of mastocytosis. | ||
:*In healthy individuals, serum tryptase levels range between <1 and 15 ng/mL; however, mast cell activation causes increased tryptase levels. | :*In healthy individuals, serum tryptase levels range between <1 and 15 ng/mL; however, mast cell activation causes increased tryptase levels. | ||
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*[[Partial thromboplastin time]] | *[[Partial thromboplastin time]] | ||
:*Elevated in a blood sample obtained immediately after attack | :*Elevated in a blood sample obtained immediately after attack | ||
==References== | ==References== | ||
Revision as of 16:08, 4 March 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Laboratory Findings
Skin lesions or suggestive clinical | |||||||||||||||||||||||||||||||||||||
Serum Tryptase
Complete blood count Complete metabolic panel | |||||||||||||||||||||||||||||||||||||
Normal complete blood count
Serum tryptase ≤ 100ng/ml | Abnormal complete blood cell count
Serum tryptase > 100 ng/ml | ||||||||||||||||||||||||||||||||||||
Simple hyperplasia with cellular atypia
| Simple hyperplasia without cellular atypia | Complex hyperplasia with cellular atypia
| Complex hyperplasia without cellular atypia
| ||||||||||||||||||||||||||||||||||
The diagnosis of systemic mastocytosis is established by demonstrating mast cell infiltration in an involved tissue, particularly the bone marrow, using special staining techniques or flow cytometry, but the measurement of serum tryptase is a good screening test, since almost all patients with systemic mastocytosis have serum tryptase levels exceeding 20 ng/mL.[1]
- Tryptase which is stored almost exclusively within the secretory granules of mast cells is the most widely used marker of mastocytosis.
- In healthy individuals, serum tryptase levels range between <1 and 15 ng/mL; however, mast cell activation causes increased tryptase levels.
- Additionally, tryptase levels in SM are assumed to correlate closely with the cumulative mast cell burden and multiorgan involvement
- Plasma and urinary histamine
- Chronically elevated plasma and urinary histamine levels and its metabolite N-methylhistamine
- Elevated in a blood sample obtained immediately after attack
References
- ↑ Koenig, Martial; Morel, Jérôme; Reynaud, Jacqueline; Varvat, Cécile; Cathébras, Pascal (2008). "An unusual cause of spontaneous bleeding in the intensive care unit – mastocytosis: a case report". Cases Journal. 1 (1): 100. doi:10.1186/1757-1626-1-100. ISSN 1757-1626.
- ↑ Ozdemir, Didem; Dagdelen, Selcuk; Erbas, Tomris; Agbaht, Kemal; Serefhanoglu, Songul; Aksu, Salih; Ersoy-Evans, Sibel (2010). "Hypotension, Syncope, and Fever in Systemic Mastocytosis without Skin Infiltration and Rapid Response to Corticosteroid and Cyclosporin: A Case Report". Case Reports in Medicine. 2010: 1–4. doi:10.1155/2010/782595. ISSN 1687-9627.