Mast cell tumor laboratory findings: Difference between revisions

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__NOTOC__
__NOTOC__
{{Mast cell tumor}}
{{Mast cell tumor}}
{{CMG}}
{{CMG}};{{AE}} {{PSK}}
==Overview==
==Overview==
Laboratory tests that may be helpful for diagnosis of mast cell tumor include [[complete blood count]], serum [[tryptase]] levels, plasma and urinary [[histamine]] levels, and coagulation profile.
==Laboratory Findings==
==Laboratory Findings==
The diagnosis of systemic mastocytosis is established by demonstrating mast cell infiltration in an involved tissue, particularly the bone marrow, using special staining techniques or flow cytometry, but the measurement of serum tryptase is a good screening test, since almost all patients with systemic mastocytosis have serum tryptase levels exceeding 20 ng/mL.<ref name="KoenigMorel2008">{{cite journal|last1=Koenig|first1=Martial|last2=Morel|first2=Jérôme|last3=Reynaud|first3=Jacqueline|last4=Varvat|first4=Cécile|last5=Cathébras|first5=Pascal|title=An unusual cause of spontaneous bleeding in the intensive care unit – mastocytosis: a case report|journal=Cases Journal|volume=1|issue=1|year=2008|pages=100|issn=1757-1626|doi=10.1186/1757-1626-1-100}}</ref>
===Diagnostic pathway of mastocytosis===
Following flow chart illustrates the diagnostic pathway of mast cell tumor:<ref name="FerranteScavone2015">{{cite journal|last1=Ferrante|first1=Giuliana|last2=Scavone|first2=Valeria|last3=Muscia|first3=Maria|last4=Adrignola|first4=Emilia|last5=Corsello|first5=Giovanni|last6=Passalacqua|first6=Giovanni|last7=La Grutta|first7=Stefania|title=The care pathway for children with urticaria, angioedema, mastocytosis|journal=World Allergy Organization Journal|volume=8|issue=1|year=2015|pages=5|issn=1939-4551|doi=10.1186/s40413-014-0052-x}}</ref>


*Complete blood count
{{familytree/start |summary=Skin lesions or suggestive clinical}}
:*Thrombocytopenia
{{familytree |boxstyle=background: #DCDCDC; | | | | | | | | | | A01 |A01=<div style="width: 12em; padding:0.2em;">'''Skin lesions or suggestive clinical features'''</div>}}
:*Eosinophilia
{{familytree| | | | | | | | | | |!| }}
*Blood tryptase levels
{{familytree |boxstyle=background: #DCDCDC; | | | | | | | | | | A01 |A01=<div style="width: 12em; padding:0.2em;">'''Serum Tryptase'''
:*Elevated plasma tryptase levels
'''Complete blood count'''
*Plasma and urinary histamine
'''Complete metabolic panel'''</div>}}
{{familytree |boxstyle=background: #DCDCDC; | | | | | | |,|-|-|-|^|-|-|-|.| }}
{{familytree |boxstyle=background: #DCDCDC; | | | | | | B01 | | | | | | B02 |B01=<div style="width: 9em; padding:0.2em;">'''Normal complete blood count'''
'''Serum tryptase ≤ 100ng/ml'''
</div>|B02=<div style="width: 9em; padding:0.2em;">'''Abnormal complete blood cell count'''
'''Serum tryptase > 100 ng/ml'''</div>}}
{{familytree| | | | | | |!| | | | | | | |!|}}
{{familytree |boxstyle=background: #DCDCDC; | | | | | | C01 | | | | | |C02 |C01=<div style="width: 9em; padding:0.2em;">'''Cutaneous mastocytosis'''
</div>|C02=<div style="width: 9em; padding:0.2em;">'''Bone marrow: biopsy and aspiration'''
</div>|}}
{{familytree |boxstyle=background: #DCDCDC; | | | | | | | | | | | | |,|-|^|-|.|}}
{{familytree |boxstyle=background: #DCDCDC; | | | | | | | | | | | | B01 | | | B02 |B01=<div style="width: 9em; padding:0.2em;">'''Negative findings:'''
'''Other diagnosis'''
</div>|B02=<div style="width: 9em; padding:0.2em;">'''Positive findings:''' '''Systemic mastocytosis'''</div>}}
{{familytree/end}}
 
===Laboratory findings===
*[[Complete blood count]]
:*[[Anemia]]
:*[[Eosinophilia]]
:*[[Thrombocytopenia]]
*[[Tryptase]] levels<ref name="OzdemirDagdelen2010">{{cite journal|last1=Ozdemir|first1=Didem|last2=Dagdelen|first2=Selcuk|last3=Erbas|first3=Tomris|last4=Agbaht|first4=Kemal|last5=Serefhanoglu|first5=Songul|last6=Aksu|first6=Salih|last7=Ersoy-Evans|first7=Sibel|title=Hypotension, Syncope, and Fever in Systemic Mastocytosis without Skin Infiltration and Rapid Response to Corticosteroid and Cyclosporin: A Case Report|journal=Case Reports in Medicine|volume=2010|year=2010|pages=1–4|issn=1687-9627|doi=10.1155/2010/782595}}</ref>
:*Tryptase which is stored almost exclusively within the secretory granules of mast cells is the most widely used marker of mastocytosis.
:*In healthy individuals, serum tryptase levels range between <1 and 15 ng/mL; however, mast cell activation causes increased tryptase levels.
:*Additionally, tryptase levels in SM are assumed to correlate closely with the cumulative mast cell burden and multiorgan involvement
*Plasma and urinary [[histamine]]
:*Chronically elevated plasma and urinary histamine levels and its metabolite N-methylhistamine
:*Chronically elevated plasma and urinary histamine levels and its metabolite N-methylhistamine
*Partial thromboplastin time
*[[Partial thromboplastin time]]
:*Elevated in a blood sample obtained immediately after attack
:*Elevated in a blood sample obtained immediately after attack
:*Kinetics of blood clotting may be altered due to fibrinogenolytic and anticoagulant activities of tryptase and heparin respectively.<ref name="KoenigMorel2008">{{cite journal|last1=Koenig|first1=Martial|last2=Morel|first2=Jérôme|last3=Reynaud|first3=Jacqueline|last4=Varvat|first4=Cécile|last5=Cathébras|first5=Pascal|title=An unusual cause of spontaneous bleeding in the intensive care unit – mastocytosis: a case report|journal=Cases Journal|volume=1|issue=1|year=2008|pages=100|issn=1757-1626|doi=10.1186/1757-1626-1-100}}</ref>
*Molecular testing for Kit D816V mutation
*[[Liver function tests]]
*[[Renal function tests]]


==References==
==References==
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[[Category:Types of cancer]]
[[Category:Types of cancer]]
[[Category:Pathology]]
[[Category:Pathology]]
[[Category:Up-To-Date]]
[[Category:Oncology]]
[[Category:Medicine]]
[[Category:Hematology]]
[[Category:Immunology]]

Latest revision as of 02:31, 27 November 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Suveenkrishna Pothuru, M.B,B.S. [2]

Overview

Laboratory tests that may be helpful for diagnosis of mast cell tumor include complete blood count, serum tryptase levels, plasma and urinary histamine levels, and coagulation profile.

Laboratory Findings

Diagnostic pathway of mastocytosis

Following flow chart illustrates the diagnostic pathway of mast cell tumor:[1]


 
 
 
 
 
 
 
 
 
Skin lesions or suggestive clinical features
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Serum Tryptase

Complete blood count

Complete metabolic panel
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Normal complete blood count

Serum tryptase ≤ 100ng/ml

 
 
 
 
 
Abnormal complete blood cell count Serum tryptase > 100 ng/ml
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Cutaneous mastocytosis
 
 
 
 
 
Bone marrow: biopsy and aspiration
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Negative findings:

Other diagnosis

 
 
Positive findings: Systemic mastocytosis

Laboratory findings

  • Tryptase which is stored almost exclusively within the secretory granules of mast cells is the most widely used marker of mastocytosis.
  • In healthy individuals, serum tryptase levels range between <1 and 15 ng/mL; however, mast cell activation causes increased tryptase levels.
  • Additionally, tryptase levels in SM are assumed to correlate closely with the cumulative mast cell burden and multiorgan involvement
  • Chronically elevated plasma and urinary histamine levels and its metabolite N-methylhistamine
  • Elevated in a blood sample obtained immediately after attack
  • Kinetics of blood clotting may be altered due to fibrinogenolytic and anticoagulant activities of tryptase and heparin respectively.[3]

References

  1. Ferrante, Giuliana; Scavone, Valeria; Muscia, Maria; Adrignola, Emilia; Corsello, Giovanni; Passalacqua, Giovanni; La Grutta, Stefania (2015). "The care pathway for children with urticaria, angioedema, mastocytosis". World Allergy Organization Journal. 8 (1): 5. doi:10.1186/s40413-014-0052-x. ISSN 1939-4551.
  2. Ozdemir, Didem; Dagdelen, Selcuk; Erbas, Tomris; Agbaht, Kemal; Serefhanoglu, Songul; Aksu, Salih; Ersoy-Evans, Sibel (2010). "Hypotension, Syncope, and Fever in Systemic Mastocytosis without Skin Infiltration and Rapid Response to Corticosteroid and Cyclosporin: A Case Report". Case Reports in Medicine. 2010: 1–4. doi:10.1155/2010/782595. ISSN 1687-9627.
  3. Koenig, Martial; Morel, Jérôme; Reynaud, Jacqueline; Varvat, Cécile; Cathébras, Pascal (2008). "An unusual cause of spontaneous bleeding in the intensive care unit – mastocytosis: a case report". Cases Journal. 1 (1): 100. doi:10.1186/1757-1626-1-100. ISSN 1757-1626.

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