Mast cell leukemia laboratory findings
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Nawal Muazam M.D.[2]
Overview
Laboratory findings consistent with the diagnosis of mast cell leukemia include abnormal complete blood count, immunohistochemistry, and flow cytometry.[1][2][3]
Mast cell leukemia laboratory findings
Laboratory findings consistent with the diagnosis of mast cell leukemia include abnormal complete blood count, biochemistry, immunohistochemistry, and flow cytometry.[1]
Complete Blood Count
On complete blood count, characteristic findings of mast cell leukemia include:[1][2]
- Bicytopenia
- Anemia
- Thrombocytopenia
- Leukopenia
- Neutropenia
Biochemistry
Total serum tryptase level is elevated in mast cell leukemia.[3]
Immunohistochemistry
On immunohistochemistry, characteristic findings of mast cell leukemia include:[1][2]
- Leukemic mast cells strongly express:
- Abnormal mast cells ususally express:[2]
- Other cell surface markers expressed by mast cells are:[2]
Flow Cytometry
Malignant mast cells overexpress the anti-apoptosis gene, B-cell lymphoma 2.[3]
References
- ↑ 1.0 1.1 1.2 1.3 Joris, Magalie; Georgin-Lavialle, Sophie; Chandesris, Marie-Olivia; Lhermitte, Ludovic; Claisse, Jean-François; Canioni, Danielle; Hanssens, Katia; Damaj, Gandhi; Hermine, Olivier; Hamidou, Mohammed (2012). "Mast Cell Leukaemia: c-KIT Mutations Are Not Always Positive". Case Reports in Hematology. 2012: 1–6. doi:10.1155/2012/517546. ISSN 2090-6560.
- ↑ 2.0 2.1 2.2 2.3 2.4 Georgin-Lavialle, S.; Lhermitte, L.; Dubreuil, P.; Chandesris, M.-O.; Hermine, O.; Damaj, G. (2012). "Mast cell leukemia". Blood. 121 (8): 1285–1295. doi:10.1182/blood-2012-07-442400. ISSN 0006-4971.
- ↑ 3.0 3.1 3.2 Biochemistry of mast cell leukemia. Wikipedia (2015). https://en.wikipedia.org/wiki/Mast_cell_leukemia. Accessed on December 1, 2015