Mast cell leukemia laboratory findings: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Mast cell leukemia}} | {{Mast cell leukemia}} | ||
{{CMG}}; {{AE}} {{NM}} | {{CMG}}; {{AE}} {{NM}}, {{S.G.}} | ||
==Overview== | ==Overview== | ||
Laboratory findings consistent with the diagnosis of mast cell leukemia include abnormal [[complete blood count]], [[ | Laboratory findings consistent with the diagnosis of [[mast cell]] leukemia include abnormal [[complete blood count]], [[biochemistry]], and [[immunohistochemistry]]. | ||
==Mast cell leukemia laboratory findings== | ==Mast cell leukemia laboratory findings== | ||
Laboratory findings consistent with the diagnosis of mast cell leukemia include abnormal [[complete blood count]], [[biochemistry]], [[immunohistochemistry | * Laboratory findings consistent with the diagnosis of mast cell leukemia include abnormal [[complete blood count]], [[biochemistry]], and [[immunohistochemistry]].<ref name="JorisGeorgin-Lavialle2012">{{cite journal|last1=Joris|first1=Magalie|last2=Georgin-Lavialle|first2=Sophie|last3=Chandesris|first3=Marie-Olivia|last4=Lhermitte|first4=Ludovic|last5=Claisse|first5=Jean-François|last6=Canioni|first6=Danielle|last7=Hanssens|first7=Katia|last8=Damaj|first8=Gandhi|last9=Hermine|first9=Olivier|last10=Hamidou|first10=Mohammed|title=Mast Cell Leukaemia: c-KIT Mutations Are Not Always Positive|journal=Case Reports in Hematology|volume=2012|year=2012|pages=1–6|issn=2090-6560|doi=10.1155/2012/517546}}</ref><ref name="Georgin-LavialleLhermitte2012">{{cite journal|last1=Georgin-Lavialle|first1=S.|last2=Lhermitte|first2=L.|last3=Dubreuil|first3=P.|last4=Chandesris|first4=M.-O.|last5=Hermine|first5=O.|last6=Damaj|first6=G.|title=Mast cell leukemia|journal=Blood|volume=121|issue=8|year=2012|pages=1285–1295|issn=0006-4971|doi=10.1182/blood-2012-07-442400}}</ref> | ||
* Patients with mast cell leukemia have more than 20% mast cells in bone marrow aspirates.<ref name="BauerLongo2017">{{cite journal|last1=Bauer|first1=James|last2=Longo|first2=Walter|last3=Yang|first3=David|title=Mast Cell Leukemia: Review of a Rare Disease and Case Report of Prolonged Survival after Allogeneic Stem Cell Transplant|journal=Human Pathology: Case Reports|volume=10|year=2017|pages=46–49|issn=22143300|doi=10.1016/j.ehpc.2017.05.003}}</ref> | |||
===Complete Blood Count=== | ===Complete Blood Count=== | ||
On complete blood count, characteristic findings of mast cell leukemia include:<ref name="JorisGeorgin-Lavialle2012">{{cite journal|last1=Joris|first1=Magalie|last2=Georgin-Lavialle|first2=Sophie|last3=Chandesris|first3=Marie-Olivia|last4=Lhermitte|first4=Ludovic|last5=Claisse|first5=Jean-François|last6=Canioni|first6=Danielle|last7=Hanssens|first7=Katia|last8=Damaj|first8=Gandhi|last9=Hermine|first9=Olivier|last10=Hamidou|first10=Mohammed|title=Mast Cell Leukaemia: c-KIT Mutations Are Not Always Positive|journal=Case Reports in Hematology|volume=2012|year=2012|pages=1–6|issn=2090-6560|doi=10.1155/2012/517546}}</ref><ref name="Georgin-LavialleLhermitte2012">{{cite journal|last1=Georgin-Lavialle|first1=S.|last2=Lhermitte|first2=L.|last3=Dubreuil|first3=P.|last4=Chandesris|first4=M.-O.|last5=Hermine|first5=O.|last6=Damaj|first6=G.|title=Mast cell leukemia|journal=Blood|volume=121|issue=8|year=2012|pages=1285–1295|issn=0006-4971|doi=10.1182/blood-2012-07-442400}}</ref> | On [[complete blood count]], characteristic findings of mast cell leukemia include:<ref name="JorisGeorgin-Lavialle2012">{{cite journal|last1=Joris|first1=Magalie|last2=Georgin-Lavialle|first2=Sophie|last3=Chandesris|first3=Marie-Olivia|last4=Lhermitte|first4=Ludovic|last5=Claisse|first5=Jean-François|last6=Canioni|first6=Danielle|last7=Hanssens|first7=Katia|last8=Damaj|first8=Gandhi|last9=Hermine|first9=Olivier|last10=Hamidou|first10=Mohammed|title=Mast Cell Leukaemia: c-KIT Mutations Are Not Always Positive|journal=Case Reports in Hematology|volume=2012|year=2012|pages=1–6|issn=2090-6560|doi=10.1155/2012/517546}}</ref><ref name="Georgin-LavialleLhermitte2012">{{cite journal|last1=Georgin-Lavialle|first1=S.|last2=Lhermitte|first2=L.|last3=Dubreuil|first3=P.|last4=Chandesris|first4=M.-O.|last5=Hermine|first5=O.|last6=Damaj|first6=G.|title=Mast cell leukemia|journal=Blood|volume=121|issue=8|year=2012|pages=1285–1295|issn=0006-4971|doi=10.1182/blood-2012-07-442400}}</ref> | ||
*Bicytopenia | *Bicytopenia | ||
*[[Anemia]] | *[[Anemia]] | ||
| Line 14: | Line 16: | ||
*[[Neutropenia]] | *[[Neutropenia]] | ||
===Biochemistry=== | ===Biochemistry=== | ||
Total serum [[tryptase]] level is elevated in mast cell leukemia.<ref name=wikipedia>Biochemistry of mast cell leukemia. Wikipedia (2015). https://en.wikipedia.org/wiki/Mast_cell_leukemia. Accessed on December 1, 2015</ref> | Total serum [[tryptase]] level is elevated in mast cell leukemia.<ref name="wikipedia">Biochemistry of mast cell leukemia. Wikipedia (2015). https://en.wikipedia.org/wiki/Mast_cell_leukemia. Accessed on December 1, 2015</ref> | ||
===Immunohistochemistry=== | ===Immunohistochemistry=== | ||
On immunohistochemistry, characteristic findings of mast cell leukemia include:<ref name="JorisGeorgin-Lavialle2012">{{cite journal|last1=Joris|first1=Magalie|last2=Georgin-Lavialle|first2=Sophie|last3=Chandesris|first3=Marie-Olivia|last4=Lhermitte|first4=Ludovic|last5=Claisse|first5=Jean-François|last6=Canioni|first6=Danielle|last7=Hanssens|first7=Katia|last8=Damaj|first8=Gandhi|last9=Hermine|first9=Olivier|last10=Hamidou|first10=Mohammed|title=Mast Cell Leukaemia: c-KIT Mutations Are Not Always Positive|journal=Case Reports in Hematology|volume=2012|year=2012|pages=1–6|issn=2090-6560|doi=10.1155/2012/517546}}</ref><ref name="Georgin-LavialleLhermitte2012">{{cite journal|last1=Georgin-Lavialle|first1=S.|last2=Lhermitte|first2=L.|last3=Dubreuil|first3=P.|last4=Chandesris|first4=M.-O.|last5=Hermine|first5=O.|last6=Damaj|first6=G.|title=Mast cell leukemia|journal=Blood|volume=121|issue=8|year=2012|pages=1285–1295|issn=0006-4971|doi=10.1182/blood-2012-07-442400}}</ref> | On [[immunohistochemistry]], characteristic findings of mast cell leukemia include:<ref name="JorisGeorgin-Lavialle2012">{{cite journal|last1=Joris|first1=Magalie|last2=Georgin-Lavialle|first2=Sophie|last3=Chandesris|first3=Marie-Olivia|last4=Lhermitte|first4=Ludovic|last5=Claisse|first5=Jean-François|last6=Canioni|first6=Danielle|last7=Hanssens|first7=Katia|last8=Damaj|first8=Gandhi|last9=Hermine|first9=Olivier|last10=Hamidou|first10=Mohammed|title=Mast Cell Leukaemia: c-KIT Mutations Are Not Always Positive|journal=Case Reports in Hematology|volume=2012|year=2012|pages=1–6|issn=2090-6560|doi=10.1155/2012/517546}}</ref><ref name="Georgin-LavialleLhermitte2012">{{cite journal|last1=Georgin-Lavialle|first1=S.|last2=Lhermitte|first2=L.|last3=Dubreuil|first3=P.|last4=Chandesris|first4=M.-O.|last5=Hermine|first5=O.|last6=Damaj|first6=G.|title=Mast cell leukemia|journal=Blood|volume=121|issue=8|year=2012|pages=1285–1295|issn=0006-4971|doi=10.1182/blood-2012-07-442400}}</ref> | ||
*Leukemic mast cells strongly express: | *Leukemic mast cells strongly express:<ref name="Georgin-LavialleLhermitte2012">{{cite journal|last1=Georgin-Lavialle|first1=S.|last2=Lhermitte|first2=L.|last3=Dubreuil|first3=P.|last4=Chandesris|first4=M.-O.|last5=Hermine|first5=O.|last6=Damaj|first6=G.|title=Mast cell leukemia|journal=Blood|volume=121|issue=8|year=2012|pages=1285–1295|issn=0006-4971|doi=10.1182/blood-2012-07-442400}}</ref> | ||
:*[[CD13]] | :*[[CD13]] | ||
:*[[CD33]] | :*[[CD33]] | ||
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:*[[CD2]] | :*[[CD2]] | ||
:*[[CD25]] | :*[[CD25]] | ||
*Other cell surface markers expressed by mast cells are:<ref name="Georgin-LavialleLhermitte2012">{{cite journal|last1=Georgin-Lavialle|first1=S.|last2=Lhermitte|first2=L.|last3=Dubreuil|first3=P.|last4=Chandesris|first4=M.-O.|last5=Hermine|first5=O.|last6=Damaj|first6=G.|title=Mast cell leukemia|journal=Blood|volume=121|issue=8|year=2012|pages=1285–1295|issn=0006-4971|doi=10.1182/blood-2012-07-442400}}</ref> | *Other cell surface markers expressed by mast cells are:<ref name="Georgin-LavialleLhermitte2012">{{cite journal|last1=Georgin-Lavialle|first1=S.|last2=Lhermitte|first2=L.|last3=Dubreuil|first3=P.|last4=Chandesris|first4=M.-O.|last5=Hermine|first5=O.|last6=Damaj|first6=G.|title=Mast cell leukemia|journal=Blood|volume=121|issue=8|year=2012|pages=1285–1295|issn=0006-4971|doi=10.1182/blood-2012-07-442400}}</ref><ref name="CostopoulosUzunov2018">{{cite journal|last1=Costopoulos|first1=Myrto|last2=Uzunov|first2=Madalina|last3=Bories|first3=Dominique|last4=Charlotte|first4=Frederic|last5=Maloum|first5=Karim|last6=Arock|first6=Michel|title=Acute mast cell leukemia: A rare but highly aggressive hematopoietic neoplasm|journal=Diagnostic Cytopathology|volume=46|issue=7|year=2018|pages=639–641|issn=87551039|doi=10.1002/dc.23965}}</ref><ref name="ZhengNong2018">{{cite journal|last1=Zheng|first1=Yalin|last2=Nong|first2=Lin|last3=Liang|first3=Li|last4=Wang|first4=Wei|last5=Li|first5=Ting|title=De novo mast cell leukemia without CD25 expression and KIT mutations: a rare case report in a 13-year-old child|journal=Diagnostic Pathology|volume=13|issue=1|year=2018|issn=1746-1596|doi=10.1186/s13000-018-0691-2}}</ref> | ||
:*[[CD11c]] | :*[[CD11c]] | ||
:*[[CD29]] | :*[[CD29]] | ||
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:*[[CD22]] | :*[[CD22]] | ||
:*[[CD54]] | :*[[CD54]] | ||
:*CD203c | |||
:*CD117 | |||
:*CD30 | |||
:*CD25 | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Latest revision as of 12:17, 22 October 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Nawal Muazam M.D.[2], Sogand Goudarzi, MD [3]
Overview
Laboratory findings consistent with the diagnosis of mast cell leukemia include abnormal complete blood count, biochemistry, and immunohistochemistry.
Mast cell leukemia laboratory findings
- Laboratory findings consistent with the diagnosis of mast cell leukemia include abnormal complete blood count, biochemistry, and immunohistochemistry.[1][2]
- Patients with mast cell leukemia have more than 20% mast cells in bone marrow aspirates.[3]
Complete Blood Count
On complete blood count, characteristic findings of mast cell leukemia include:[1][2]
- Bicytopenia
- Anemia
- Thrombocytopenia
- Leukopenia
- Neutropenia
Biochemistry
Total serum tryptase level is elevated in mast cell leukemia.[4]
Immunohistochemistry
On immunohistochemistry, characteristic findings of mast cell leukemia include:[1][2]
- Leukemic mast cells strongly express:[2]
- Abnormal mast cells ususally express:[2]
References
- ↑ 1.0 1.1 1.2 Joris, Magalie; Georgin-Lavialle, Sophie; Chandesris, Marie-Olivia; Lhermitte, Ludovic; Claisse, Jean-François; Canioni, Danielle; Hanssens, Katia; Damaj, Gandhi; Hermine, Olivier; Hamidou, Mohammed (2012). "Mast Cell Leukaemia: c-KIT Mutations Are Not Always Positive". Case Reports in Hematology. 2012: 1–6. doi:10.1155/2012/517546. ISSN 2090-6560.
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Georgin-Lavialle, S.; Lhermitte, L.; Dubreuil, P.; Chandesris, M.-O.; Hermine, O.; Damaj, G. (2012). "Mast cell leukemia". Blood. 121 (8): 1285–1295. doi:10.1182/blood-2012-07-442400. ISSN 0006-4971.
- ↑ Bauer, James; Longo, Walter; Yang, David (2017). "Mast Cell Leukemia: Review of a Rare Disease and Case Report of Prolonged Survival after Allogeneic Stem Cell Transplant". Human Pathology: Case Reports. 10: 46–49. doi:10.1016/j.ehpc.2017.05.003. ISSN 2214-3300.
- ↑ Biochemistry of mast cell leukemia. Wikipedia (2015). https://en.wikipedia.org/wiki/Mast_cell_leukemia. Accessed on December 1, 2015
- ↑ Costopoulos, Myrto; Uzunov, Madalina; Bories, Dominique; Charlotte, Frederic; Maloum, Karim; Arock, Michel (2018). "Acute mast cell leukemia: A rare but highly aggressive hematopoietic neoplasm". Diagnostic Cytopathology. 46 (7): 639–641. doi:10.1002/dc.23965. ISSN 8755-1039.
- ↑ Zheng, Yalin; Nong, Lin; Liang, Li; Wang, Wei; Li, Ting (2018). "De novo mast cell leukemia without CD25 expression and KIT mutations: a rare case report in a 13-year-old child". Diagnostic Pathology. 13 (1). doi:10.1186/s13000-018-0691-2. ISSN 1746-1596.