Marburg hemorrhagic fever differential diagnosis: Difference between revisions

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Treatment should be based on the most likely etiology of fever according to local [[epidemiology]]. If the [[fever]] continues after 3 days of recommended treatment, and if the patient has [[signs]] such as [[bleeding]] or [[shock]], a viral hemorrhagic fever should be considered. It is important to review the patient’s history for any contact with someone who was ill with [[fever]] and [[bleeding]] or who died from an unexplained [[illness]] with [[fever]] and [[bleeding]].  
Treatment should be based on the most likely etiology of fever according to local [[epidemiology]]. If the [[fever]] continues after 3 days of recommended treatment, and if the patient has [[signs]] such as [[bleeding]] or [[shock]], a viral hemorrhagic fever should be considered. It is important to review the patient’s history for any contact with someone who was ill with [[fever]] and [[bleeding]] or who died from an unexplained [[illness]] with [[fever]] and [[bleeding]].  
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Revision as of 19:45, 19 October 2017

Marburg hemorrhagic fever Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief:

Overview

Differentiating Marburg Hemorrhagic Fever from other Diseases

Marburg hemorrhagic fever must be differentiated from other diseases that may cause fever, abdominal pain, diarrhea, vomiting and bleeding such as:

Incubation

period

Vector Symptoms Differentiating

Features

Diagnosis
fever abdominal pain diarrhea bleeding Differentiating

Laboratory findings

exam findings
Marburg Hemorrhagic Fever  2-21
Ebola hemorrhagic fever 2-21
Lassa hemorrhagic fever
Crimean-Congo hemorrhagic fever
Malaria
Typhoid fever
Shigellosis
Cholera
Leptospirosis 2-30
Plague
Rickettsiosis
Relapsing fever
Meningitis
Hepatitis
Dengue

Treatment should be based on the most likely etiology of fever according to local epidemiology. If the fever continues after 3 days of recommended treatment, and if the patient has signs such as bleeding or shock, a viral hemorrhagic fever should be considered. It is important to review the patient’s history for any contact with someone who was ill with fever and bleeding or who died from an unexplained illness with fever and bleeding.


Shown below is a table summarizing the typical findings of the differential diagnoses of MHF.

Disease Findings
Shigellosis & other bacterial enteric infections Presents with diarrhea, possibly bloody, accompanied by fever, nausea, and sometimes toxemia, vomiting, cramps, and tenesmus. Stools contain blood and mucous in a typical case. A search for possible sites of bacterial infection, together with cultures and blood smears, should be made. Presence of leucocytosis distinguishes bacterial infections.
Typhoid fever Presents with fever, headache, rash, gastrointestinal symptoms, with lymphadenopathy, relative bradycardia, cough and leucopenia and sometimes sore throat. Blood and stool culture can demonstrate causative bacteria.
Malaria Presents with acute fever, headache and sometime diarrhea (children). Blood smears must be examined for malaria parasites. Presence of parasites does not exclude concurrent viral infection. Antimalarial must be prescribed in an attempt at therapy.
Lassa fever Disease onset is usually gradual, with fever, sore throat, cough, pharyngitis, and facial edema in the later stages. Inflammation and exudation of the pharynx and conjunctiva are common.
Yellow fever and other Flaviviridae Present with hemorrhagic complications. Epidemiological investigation may reveal a pattern of disease transmission by an insect vector. Virus isolation and serological investigation serves to distinguish these virus. Confirmed history of previous yellow fever vaccination will rule out yellow fever.
Others Viral hepatitis, leptospirosis, rheumatic fever, typhus, and mononucleosis produce signs and symptoms that may be confused with Ebola in the early stages of infection.
Table adapted from WHO Guidelines For Epidemic Preparedness And Response: Ebola Haemorrhagic Fever [1]

References

  1. "WHO Guidelines For Epidemic Preparedness And Response: Ebola Haemorrhagic Fever".