Difference between revisions of "Management of the thrombotic lesion"

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(New page: {{SI}} {{WikiDoc Cardiology Network Infobox}} {{CMG}}<br/> '''Associate Editors-In-Chief:''' ==Goals of Treatment== There are several main goals in treating thrombotic lesions, including:...)
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==Treatment Choices==
 
==Treatment Choices==
 
===Pharmacologic Therapy===
 
===Pharmacologic Therapy===
'''Antiplatelet therapy:''' Aspirin, platelet glycoprotein IIb/IIIa receptor (GP IIb/IIIa) antagonists (abciximab, eptifibatide, tirofiban), ADP receptor/P2Y12 inhibitors (plavix, ticagrelor, prasugrel)
+
*Antiplatelet therapy: Aspirin, platelet glycoprotein IIb/IIIa receptor (GP IIb/IIIa) antagonists (abciximab, eptifibatide, tirofiban), ADP receptor/P2Y12 inhibitors (plavix, ticagrelor, prasugrel)
  
'''Antithrombin Therapy:''' Ufractionated heparin (UFH), low molecular weight heparin (LMWH). Fondaparinux not recommended in primary PCI.
+
*Antithrombin Therapy: Ufractionated heparin (UFH), low molecular weight heparin (LMWH). Fondaparinux not recommended in primary PCI.
  
'''Direct Thrombin Inhibitors:''' hirudin, bivalirudin, argatroban
+
*Direct Thrombin Inhibitors: hirudin, bivalirudin, argatroban
  
'''Thrombolytic Therapy:''' Urokinase (UK), tissue plasminogen activator (tPA) for STEMI when other pharmacologic and mechanical treatments are not successful
+
*Thrombolytic Therapy: Urokinase (UK), tissue plasminogen activator (tPA) for STEMI when other pharmacologic and mechanical treatments are not successful
  
 
===Mechanical Therapy===
 
===Mechanical Therapy===
'''Aspiration Catheter:''' (Export, Pronto) is the choice prior to the other interventions listed below 
 
  
'''Percutaneous Coronary Intervention (PCI):''' Bare metal or drug-eluting stent particularly direct stenting without pre-dilation by conventional balloon angioplasty
+
*Aspiration Catheter: (Export, Pronto) is the choice prior to the other interventions listed below 
  
'''Distal Protection:''' (Percusurge guardwire, Triactive, Spider wire, Proxis) particularly in saphenous vein grafts
+
*Percutaneous Coronary Intervention (PCI): Bare metal or drug-eluting stent particularly direct stenting without pre-dilation by conventional balloon angioplasty
  
'''Percutaneous Transluminal Coronary Angioplasty (PTCA)'''
+
*Distal Protection: (Percusurge guardwire, Triactive, Spider wire, Proxis) particularly in saphenous vein grafts
  
'''Directional Atherectomy'''.
+
*Percutaneous Transluminal Coronary Angioplasty (PTCA)
  
'''Transluminal Extraction Catheter (TEC)'''
+
*Directional Atherectomy
  
'''Rheolytic Thrombectomy (Possis Angiojet)'''
+
*Transluminal Extraction Catheter (TEC)
 +
 
 +
*Rheolytic Thrombectomy (Possis Angiojet)
  
 
{{SIB}}
 
{{SIB}}

Revision as of 13:45, 6 August 2010

WikiDoc Resources for Management of the thrombotic lesion

Articles

Most recent articles on Management of the thrombotic lesion

Most cited articles on Management of the thrombotic lesion

Review articles on Management of the thrombotic lesion

Articles on Management of the thrombotic lesion in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Management of the thrombotic lesion

Images of Management of the thrombotic lesion

Photos of Management of the thrombotic lesion

Podcasts & MP3s on Management of the thrombotic lesion

Videos on Management of the thrombotic lesion

Evidence Based Medicine

Cochrane Collaboration on Management of the thrombotic lesion

Bandolier on Management of the thrombotic lesion

TRIP on Management of the thrombotic lesion

Clinical Trials

Ongoing Trials on Management of the thrombotic lesion at Clinical Trials.gov

Trial results on Management of the thrombotic lesion

Clinical Trials on Management of the thrombotic lesion at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Management of the thrombotic lesion

NICE Guidance on Management of the thrombotic lesion

NHS PRODIGY Guidance

FDA on Management of the thrombotic lesion

CDC on Management of the thrombotic lesion

Books

Books on Management of the thrombotic lesion

News

Management of the thrombotic lesion in the news

Be alerted to news on Management of the thrombotic lesion

News trends on Management of the thrombotic lesion

Commentary

Blogs on Management of the thrombotic lesion

Definitions

Definitions of Management of the thrombotic lesion

Patient Resources / Community

Patient resources on Management of the thrombotic lesion

Discussion groups on Management of the thrombotic lesion

Patient Handouts on Management of the thrombotic lesion

Directions to Hospitals Treating Management of the thrombotic lesion

Risk calculators and risk factors for Management of the thrombotic lesion

Healthcare Provider Resources

Symptoms of Management of the thrombotic lesion

Causes & Risk Factors for Management of the thrombotic lesion

Diagnostic studies for Management of the thrombotic lesion

Treatment of Management of the thrombotic lesion

Continuing Medical Education (CME)

CME Programs on Management of the thrombotic lesion

International

Management of the thrombotic lesion en Espanol

Management of the thrombotic lesion en Francais

Business

Management of the thrombotic lesion in the Marketplace

Patents on Management of the thrombotic lesion

Experimental / Informatics

List of terms related to Management of the thrombotic lesion

Cardiology Network
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Discuss Management of the thrombotic lesion further in the WikiDoc Cardiology Network
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Associate Editors-In-Chief:

Goals of Treatment

There are several main goals in treating thrombotic lesions, including:

  • Reperfusion of the epicardial artery and the downstream microvasculature
  • Resolution/reduction of [[thrombus burden
  • Avoid/minimize distal embolization
  • Avoid/reduce thrombotic major adverse cardiac events (death, MI, recurrent ischemia, urgent target vessel revascularization (TVR))

Treatment Choices

Pharmacologic Therapy

  • Antiplatelet therapy: Aspirin, platelet glycoprotein IIb/IIIa receptor (GP IIb/IIIa) antagonists (abciximab, eptifibatide, tirofiban), ADP receptor/P2Y12 inhibitors (plavix, ticagrelor, prasugrel)
  • Antithrombin Therapy: Ufractionated heparin (UFH), low molecular weight heparin (LMWH). Fondaparinux not recommended in primary PCI.
  • Direct Thrombin Inhibitors: hirudin, bivalirudin, argatroban
  • Thrombolytic Therapy: Urokinase (UK), tissue plasminogen activator (tPA) for STEMI when other pharmacologic and mechanical treatments are not successful

Mechanical Therapy

  • Aspiration Catheter: (Export, Pronto) is the choice prior to the other interventions listed below
  • Percutaneous Coronary Intervention (PCI): Bare metal or drug-eluting stent particularly direct stenting without pre-dilation by conventional balloon angioplasty
  • Distal Protection: (Percusurge guardwire, Triactive, Spider wire, Proxis) particularly in saphenous vein grafts
  • Percutaneous Transluminal Coronary Angioplasty (PTCA)
  • Directional Atherectomy
  • Transluminal Extraction Catheter (TEC)
  • Rheolytic Thrombectomy (Possis Angiojet)

Cost Effectiveness of Management of the thrombotic lesion

| group5 = Clinical Trials Involving Management of the thrombotic lesion | list5 = Ongoing Trials on Management of the thrombotic lesion at Clinical Trials.govTrial results on Management of the thrombotic lesionClinical Trials on Management of the thrombotic lesion at Google


| group6 = Guidelines / Policies / Government Resources (FDA/CDC) Regarding Management of the thrombotic lesion | list6 = US National Guidelines Clearinghouse on Management of the thrombotic lesionNICE Guidance on Management of the thrombotic lesionNHS PRODIGY GuidanceFDA on Management of the thrombotic lesionCDC on Management of the thrombotic lesion


| group7 = Textbook Information on Management of the thrombotic lesion | list7 = Books and Textbook Information on Management of the thrombotic lesion


| group8 = Pharmacology Resources on Management of the thrombotic lesion | list8 = AND (Dose)}} Dosing of Management of the thrombotic lesionAND (drug interactions)}} Drug interactions with Management of the thrombotic lesionAND (side effects)}} Side effects of Management of the thrombotic lesionAND (Allergy)}} Allergic reactions to Management of the thrombotic lesionAND (overdose)}} Overdose information on Management of the thrombotic lesionAND (carcinogenicity)}} Carcinogenicity information on Management of the thrombotic lesionAND (pregnancy)}} Management of the thrombotic lesion in pregnancyAND (pharmacokinetics)}} Pharmacokinetics of Management of the thrombotic lesion


| group9 = Genetics, Pharmacogenomics, and Proteinomics of Management of the thrombotic lesion | list9 = AND (pharmacogenomics)}} Genetics of Management of the thrombotic lesionAND (pharmacogenomics)}} Pharmacogenomics of Management of the thrombotic lesionAND (proteomics)}} Proteomics of Management of the thrombotic lesion


| group10 = Newstories on Management of the thrombotic lesion | list10 = Management of the thrombotic lesion in the newsBe alerted to news on Management of the thrombotic lesionNews trends on Management of the thrombotic lesion


| group11 = Commentary on Management of the thrombotic lesion | list11 = Blogs on Management of the thrombotic lesion

| group12 = Patient Resources on Management of the thrombotic lesion | list12 = Patient resources on Management of the thrombotic lesionDiscussion groups on Management of the thrombotic lesionPatient Handouts on Management of the thrombotic lesionDirections to Hospitals Treating Management of the thrombotic lesionRisk calculators and risk factors for Management of the thrombotic lesion


| group13 = Healthcare Provider Resources on Management of the thrombotic lesion | list13 = Symptoms of Management of the thrombotic lesionCauses & Risk Factors for Management of the thrombotic lesionDiagnostic studies for Management of the thrombotic lesionTreatment of Management of the thrombotic lesion

| group14 = Continuing Medical Education (CME) Programs on Management of the thrombotic lesion | list14 = CME Programs on Management of the thrombotic lesion

| group15 = International Resources on Management of the thrombotic lesion | list15 = Management of the thrombotic lesion en EspanolManagement of the thrombotic lesion en Francais

| group16 = Business Resources on Management of the thrombotic lesion | list16 = Management of the thrombotic lesion in the MarketplacePatents on Management of the thrombotic lesion

| group17 = Informatics Resources on Management of the thrombotic lesion | list17 = List of terms related to Management of the thrombotic lesion


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