Malacoplakia
| Malakoplakia | |
| Classification and external resources | |
| File:Michaelis-Gutmann bodies - very high mag - cropped.jpg | |
|---|---|
| Micrograph showing the characteristic finding of malakoplakia (Michaelis-Gutmann bodies). H&E stain. | |
| DiseasesDB | 29128 |
| eMedicine | derm/872 |
| MeSH | D008287 |
Malakoplakia or Malacoplakia is a rare inflammatory condition which makes its presence known as a papule, plaque or ulceration that usually affects the genitourinary tract.[1]:274 However, it may also be associated with other bodily organs. It was initially described in the early 1900s as soft yellowish plaques found on the mucosa of the urinary bladder. Microscopically it is characterized by the presence of foamy histiocytes with basophilic inclusions called Michaelis-Gutmann bodies.
It usually involves gram negative bacteria.[2]
Causes
Malakoplakia is thought to result from the insufficient killing of bacteria by macrophages. Therefore, the partially digested bacteria accumulate in macrophages and leads to a deposition of iron and calcium. The impairment of bactericidal activity manifests itself as the formation of an ulcer, plaque or papule.
Malakoplakia is associated with patients with a history of immunosuppression due to lymphoma, diabetes mellitus, renal transplantation, or because of long-term therapy with systemic corticosteroids.
Treatment
Today, antibiotics are used for treatment of malakoplakia.
Antimicrobial therapy
- Malacoplakia[3]
- Preferred regimen (1): Bethanechol chloride AND Ciprofloxacin 400 mg IV q12h
- Preferred regimen (2): Bethanechol chloride AND TMP-SMX 2 mg/kg (TMP component IV q6h)
See also
References
- ↑ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.
- ↑ Liang Cheng; David G. Bostwick (2006). Essentials of anatomic pathology. Springer. pp. 1180–. ISBN 978-1-58829-461-6. Retrieved 15 May 2010.
- ↑ Gilbert, David (2015). The Sanford guide to antimicrobial therapy. Sperryville, Va: Antimicrobial Therapy. ISBN 978-1930808843.