Magnesium sulfate (oral, topical): Difference between revisions

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(Created page with "{{DrugProjectFormSinglePage |authorTag= <!--Overview--> |genericName= |aOrAn= a |drugClass= |indication= |hasBlackBoxWarning= Yes |adverseReactions= <!--Bla...")
 
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{{DrugProjectFormSinglePage
{{DrugProjectFormSinglePage
|authorTag=
|authorTag={{AV}}




<!--Overview-->
<!--Overview-->


|genericName=
|genericName=Magnesium sulfate (oral, topical)




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a
a


|drugClass=
|drugClass=[[saline laxative]]






|indication=
|indication=occasional constipation (irregularity)




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|hasBlackBoxWarning=
|hasBlackBoxWarning=


Yes


|adverseReactions=
|adverseReactions=
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|fdaLIADAdult=
|fdaLIADAdult=
*Uses for Oral Laxative
:*for relief of occasional constipation (irregularity)
:*this product generally produces bowel movement in 1/2 to 6 hours


*For Soaking


:*For external use as a soaking aid for minor sprains and bruises.
====Directions====
*do not exceed recommended daily dosage
*drink a full glass (8 ounces) of liquie with each dose
*may be taken as a single daily dose or in divided doses
*dissolve the dose in 8 ounces of water. Lemon juice may be added to improve the taste
*adults and children 12 years and over - 2 to 6 level teaspoons (10 to 30 grams) daily
*children 6 to under 12 years - 1 to 2 level teaspoons (5 to 10 grams) daily
*children under 6 years - consult a doctor
*Directions for Soaking
:*Directions: Dissolve 2 cupfuls of this product per gallon of water. Apply with bandages or towelling for 30 minutes up to three times a day, or use as a soak or in bath. Use warm water for best results.


<!--Off-Label Use and Dosage (Adult)-->
<!--Off-Label Use and Dosage (Adult)-->
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|warnings=
|warnings=


* Description
*Warnings for Soaking
 
====Precautions====
 
* Description


:*CAUTION: If prompt relief is not obtained or there is evidence of infection, discontinue use and consult your physician. Hot or warm soaks should not be used by individuals with diabetes except on the advice of a physician. Keep out of reach of children.
*Ask a doctor before use if you have
:*kidney disease
:*a magnesium-restricted diet
:*abdominal pail, nausea or vomiting
:*noticed a sudden change in bowel habits that persists over a period of 2 weeks
:*already used a laxative for a period longer than 1 week
<!--Adverse Reactions-->
<!--Adverse Reactions-->


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|drugInteractions=
|drugInteractions=


* Drug
:* Description


<!--Use in Specific Populations-->
<!--Use in Specific Populations-->


|useInPregnancyFDA=
|useInPregnancyFDA=
* '''Pregnancy Category'''
*If pregnant or breast-feeding, ask a health professional before use.


|useInPregnancyAUS=
|useInPregnancyAUS=
* '''Australian Drug Evaluation Committee (ADEC) Pregnancy Category'''
 


There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of {{PAGENAME}} in women who are pregnant.
There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of {{PAGENAME}} in women who are pregnant.


|useInLaborDelivery=
|useInLaborDelivery=
There is no FDA guidance on use of {{PAGENAME}} during labor and delivery.
*If pregnant or breast-feeding, ask a health professional before use.
 
|useInNursing=
|useInNursing=
There is no FDA guidance on the use of {{PAGENAME}} with respect to nursing mothers.
There is no FDA guidance on the use of {{PAGENAME}} with respect to nursing mothers.


|useInPed=
|useInPed=
There is no FDA guidance on the use of {{PAGENAME}} with respect to pediatric patients.
*Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away.
 
|useInGeri=
|useInGeri=
There is no FDA guidance on the use of {{PAGENAME}} with respect to geriatric patients.
There is no FDA guidance on the use of {{PAGENAME}} with respect to geriatric patients.
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* Oral
* Oral


* Intravenous
* Topical


|monitoring=
|monitoring=
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There is limited information regarding <i>Monitoring</i> of {{PAGENAME}} in the drug label.
There is limited information regarding <i>Monitoring</i> of {{PAGENAME}} in the drug label.


* Description


<!--IV Compatibility-->
<!--IV Compatibility-->
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<!--Drug box 2-->
<!--Drug box 2-->


|drugBox=
|drugBox={{chembox2
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 476997098
| Name = Magnesium sulfate
| ImageFile = Magnesium sulfate anhydrous.jpg
| ImageSize = 200px
| ImageCaption = Anhydrous magnesium sulfate
| ImageFile2 = Magnesium sulfate.JPG
| ImageSize2 = 200px
| ImageCaption2 = [[Epsomite]] (heptahydrate)
| IUPACName = Magnesium sulfate
| OtherNames = Epsom salt (heptahydrate)<br /> English salt<br/>Bitter salts
| Section1 = {{Chembox Identifiers
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = ML30MJ2U7I
| ChEMBL_Ref = {{ebicite|changed|EBI}}
| ChEMBL = 1200456
| InChI = 1/Mg.H2O4S/c;1-5(2,3)4/h;(H2,1,2,3,4)/q+2;/p-2
| InChIKey = CSNNHWWHGAXBCP-NUQVWONBAQ
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = DB00653
| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEBI = 32599
| SMILES = [Mg+2].[O-]S([O-])(=O)=O
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/Mg.H2O4S/c;1-5(2,3)4/h;(H2,1,2,3,4)/q+2;/p-2
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = CSNNHWWHGAXBCP-UHFFFAOYSA-L
| CASNo = 7487-88-9
| CASNo_Ref = {{cascite|correct|CAS}}
| CASNo1_Ref = {{cascite|correct|??}}
| CASNo1 = 14168-73-1
| CASNo1_Comment = (monohydrate)
| CASNo2_Ref = {{cascite|correct|??}}
| CASNo2 = 24378-31-2
| CASNo2_Comment = (tetrahydrate)
| CASNo3_Ref = {{cascite|correct|??}}
| CASNo3 = 15553-21-6
| CASNo3_Comment = (pentahydrate)
| CASNo4_Ref = {{cascite|correct|??}}
| CASNo4 = 13778-97-7
| CASNo4_Comment = (hexahydrate)
| CASNo5_Ref = {{cascite|correct|??}}
| CASNo5 = 10034-99-8
| CASNo5_Comment = (heptahydrate)
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 22515
| PubChem = 24083
| EINECS =
| RTECS = OM4500000
| ATCCode_prefix = A06
| ATCCode_suffix = AD04
| ATC_Supplemental = {{ATC|A12|CC02}} {{ATC|B05|XA05}} {{ATC|D11|AX05}} {{ATC|V04|CC02}}
}}
| Section2 = {{Chembox Properties
| Formula = MgSO<sub>4</sub>
| Appearance = white crystalline solid
| Odor = odorless
| Density = 2.66 g/cm<sup>3</sup> (anhydrous) <br /> 2.445 g/cm<sup>3</sup> (monohydrate) <br /> 1.68 g/cm<sup>3</sup> (heptahydrate)<br /> 1.512 g/cm<sup>3</sup> (11-hydrate)
| MolarMass = 120.366 g/mol (anhydrous)<br/>138.38 g/mol (monohydrate)<br />174.41 g/mol (trihydrate)<br />210.44 g/mol (pentahydrate)<br />228.46 g/mol (hexahydrate)<br />246.47 g/mol (heptahydrate)
| Solubility = ''anhydrous'' <br /> 26.9 g/100 mL (0 °C) <br /> 35.1 g/100 mL (20 °C) <br> 50.2 g/100 mL (100 °C) <hr> ''heptahydrate'' <br /> 71 g/100 mL (20 °C)
| SolubleOther = 1.16 g/100 mL (18°C, [[ether]]) <br /> slightly soluble in [[alcohol]], [[glycerol]] <br /> insoluble in [[acetone]]
| MeltingPt = anhydrous decomposes at&nbsp;1,124°C<br />monohydrate decomposes at&nbsp;200°C<br />heptahydrate decomposes at&nbsp;150°C<br />undecahydrate decomposes at&nbsp;2°C
| RefractIndex = 1.523 (monohydrate) <br /> 1.433 (heptahydrate)
}}
| Section3 = {{Chembox Structure
| Coordination =
| CrystalStruct = [[monoclinic]] (hydrate)
}}
| Section7 = {{Chembox Hazards
| ExternalMSDS = [http://hazard.com/msds/mf/baker/baker/files/m0234.htm External MSDS]
| EUIndex = Not listed
| NFPA-H = 1
| NFPA-F = 0
| NFPA-R = 0
}}
| Section8 = {{Chembox Related
| OtherCations = [[Beryllium sulfate]]<br/>[[Calcium sulfate]]<br/>[[Strontium sulfate]]<br/>[[Barium sulfate]]
| OtherCpds =
}}
}}




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|mechAction=
|mechAction=


*
 


<!--Structure-->
<!--Structure-->
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|structure=
|structure=


*


: [[File:{{PAGENAME}}01.png|thumb|none|600px|This image is provided by the National Library of Medicine.]]
: [[File:{{PAGENAME}}01.png|thumb|none|600px|This image is provided by the National Library of Medicine.]]
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|howSupplied=
|howSupplied=


*


<!--Patient Counseling Information-->
<!--Patient Counseling Information-->
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|brandNames=
|brandNames=


* ®<ref>{{Cite web | title =  | url =  }}</ref>
>


<!--Look-Alike Drug Names-->
<!--Look-Alike Drug Names-->


|lookAlike=
|lookAlike=
* A® — B®<ref name="www.ismp.org">{{Cite web  | last =  | first =  | title = http://www.ismp.org | url = http://www.ismp.org | publisher =  | date =  }}</ref>


<!--Drug Shortage Status-->
<!--Drug Shortage Status-->
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{{LabelImage
{{LabelImage
|fileName={{PAGENAME}}11.png|This image is provided by the National Library of Medicine.
|fileName={{PAGENAME}}02.png|This image is provided by the National Library of Medicine.
}}
}}


{{LabelImage
{{LabelImage
|fileName={{PAGENAME}}11.png|This image is provided by the National Library of Medicine.
|fileName={{PAGENAME}}03.png|This image is provided by the National Library of Medicine.
}}
}}



Revision as of 15:31, 19 May 2015

Magnesium sulfate (oral, topical)
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aparna Vuppala, M.B.B.S. [2]

Disclaimer

WikiDoc MAKES NO GUARANTEE OF VALIDITY. WikiDoc is not a professional health care provider, nor is it a suitable replacement for a licensed healthcare provider. WikiDoc is intended to be an educational tool, not a tool for any form of healthcare delivery. The educational content on WikiDoc drug pages is based upon the FDA package insert, National Library of Medicine content and practice guidelines / consensus statements. WikiDoc does not promote the administration of any medication or device that is not consistent with its labeling. Please read our full disclaimer here.

Overview

Magnesium sulfate (oral, topical) is a saline laxative that is FDA approved for the {{{indicationType}}} of occasional constipation (irregularity). Common adverse reactions include .

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

  • Uses for Oral Laxative
  • for relief of occasional constipation (irregularity)
  • this product generally produces bowel movement in 1/2 to 6 hours
  • For Soaking
  • For external use as a soaking aid for minor sprains and bruises.

Directions

  • do not exceed recommended daily dosage
  • drink a full glass (8 ounces) of liquie with each dose
  • may be taken as a single daily dose or in divided doses
  • dissolve the dose in 8 ounces of water. Lemon juice may be added to improve the taste
  • adults and children 12 years and over - 2 to 6 level teaspoons (10 to 30 grams) daily
  • children 6 to under 12 years - 1 to 2 level teaspoons (5 to 10 grams) daily
  • children under 6 years - consult a doctor
  • Directions for Soaking
  • Directions: Dissolve 2 cupfuls of this product per gallon of water. Apply with bandages or towelling for 30 minutes up to three times a day, or use as a soak or in bath. Use warm water for best results.

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Magnesium sulfate (oral, topical) in adult patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Magnesium sulfate (oral, topical) in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

There is limited information regarding FDA-Labeled Use of Magnesium sulfate (oral, topical) in pediatric patients.

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Magnesium sulfate (oral, topical) in pediatric patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Magnesium sulfate (oral, topical) in pediatric patients.

Contraindications

  • Condition1

Warnings

  • Warnings for Soaking
  • CAUTION: If prompt relief is not obtained or there is evidence of infection, discontinue use and consult your physician. Hot or warm soaks should not be used by individuals with diabetes except on the advice of a physician. Keep out of reach of children.
  • Ask a doctor before use if you have
  • kidney disease
  • a magnesium-restricted diet
  • abdominal pail, nausea or vomiting
  • noticed a sudden change in bowel habits that persists over a period of 2 weeks
  • already used a laxative for a period longer than 1 week

Adverse Reactions

Clinical Trials Experience

There is limited information regarding Clinical Trial Experience of Magnesium sulfate (oral, topical) in the drug label.

Postmarketing Experience

There is limited information regarding Postmarketing Experience of Magnesium sulfate (oral, topical) in the drug label.

Drug Interactions

There is limited information regarding Magnesium sulfate (oral, topical) Drug Interactions in the drug label.

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA):

  • If pregnant or breast-feeding, ask a health professional before use.


Pregnancy Category (AUS): There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Magnesium sulfate (oral, topical) in women who are pregnant.

Labor and Delivery

  • If pregnant or breast-feeding, ask a health professional before use.

Nursing Mothers

There is no FDA guidance on the use of Magnesium sulfate (oral, topical) with respect to nursing mothers.

Pediatric Use

  • Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away.

Geriatic Use

There is no FDA guidance on the use of Magnesium sulfate (oral, topical) with respect to geriatric patients.

Gender

There is no FDA guidance on the use of Magnesium sulfate (oral, topical) with respect to specific gender populations.

Race

There is no FDA guidance on the use of Magnesium sulfate (oral, topical) with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Magnesium sulfate (oral, topical) in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Magnesium sulfate (oral, topical) in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Magnesium sulfate (oral, topical) in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Magnesium sulfate (oral, topical) in patients who are immunocompromised.

Administration and Monitoring

Administration

  • Oral
  • Topical

Monitoring

There is limited information regarding Monitoring of Magnesium sulfate (oral, topical) in the drug label.

IV Compatibility

There is limited information regarding IV Compatibility of Magnesium sulfate (oral, topical) in the drug label.

Overdosage

There is limited information regarding Chronic Overdose of Magnesium sulfate (oral, topical) in the drug label.

Pharmacology

Template:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox E numberTemplate:Chembox RTECSTemplate:Chembox AppearanceTemplate:Chembox OdourTemplate:Chembox DensityTemplate:Chembox MeltingPtTemplate:Chembox SolubilityInWaterTemplate:Chembox SolubilityTemplate:Chembox RefractIndexTemplate:Chembox StructureTemplate:Chembox NFPATemplate:Chembox OtherCationsTemplate:Chembox Supplement
Template:Chembox header2 | Magnesium sulfate
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
DrugBank
ECHA InfoCard Lua error in Module:Wikidata at line 879: attempt to index field 'wikibase' (a nil value). Lua error in Module:Wikidata at line 879: attempt to index field 'wikibase' (a nil value).
UNII
Properties
MgSO4
Molar mass 120.366 g/mol (anhydrous)
138.38 g/mol (monohydrate)
174.41 g/mol (trihydrate)
210.44 g/mol (pentahydrate)
228.46 g/mol (hexahydrate)
246.47 g/mol (heptahydrate)
Hazards
Related compounds
Template:Chembox header2 | Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)

Infobox disclaimer and references

Mechanism of Action

There is limited information regarding Magnesium sulfate (oral, topical) Mechanism of Action in the drug label.

Structure

File:Magnesium sulfate (oral, topical)01.png
This image is provided by the National Library of Medicine.

Pharmacodynamics

There is limited information regarding Pharmacodynamics of Magnesium sulfate (oral, topical) in the drug label.

Pharmacokinetics

There is limited information regarding Pharmacokinetics of Magnesium sulfate (oral, topical) in the drug label.

Nonclinical Toxicology

There is limited information regarding Nonclinical Toxicology of Magnesium sulfate (oral, topical) in the drug label.

Clinical Studies

There is limited information regarding Clinical Studies of Magnesium sulfate (oral, topical) in the drug label.

How Supplied

There is limited information regarding Magnesium sulfate (oral, topical) How Supplied in the drug label.

Storage

There is limited information regarding Magnesium sulfate (oral, topical) Storage in the drug label.

Images

Drug Images

{{#ask: Page Name::Magnesium sulfate (oral, topical) |?Pill Name |?Drug Name |?Pill Ingred |?Pill Imprint |?Pill Dosage |?Pill Color |?Pill Shape |?Pill Size (mm) |?Pill Scoring |?NDC |?Drug Author |format=template |template=DrugPageImages |mainlabel=- |sort=Pill Name }}

Package and Label Display Panel

{{#ask: Label Page::Magnesium sulfate (oral, topical) |?Label Name |format=template |template=DrugLabelImages |mainlabel=- |sort=Label Page }}

Patient Counseling Information

There is limited information regarding Patient Counseling Information of Magnesium sulfate (oral, topical) in the drug label.

Precautions with Alcohol

  • Alcohol-Magnesium sulfate (oral, topical) interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

>

Look-Alike Drug Names

There is limited information regarding Magnesium sulfate (oral, topical) Look-Alike Drug Names in the drug label.

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.




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