Macrophage colony-stimulating factor

Colony stimulating factor 1 (macrophage)
PDB rendering based on 1hmc.
Identifiers
Symbols	CSF1 ; MCSF; MGC31930
External IDs	Template:OMIM5 Template:MGI HomoloGene: 7282
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Macrophage colony-stimulating factor, or M-CSF, is a secreted cytokine which influences hemopoietic stem cells to differentiate into macrophages or other related cell types. Eukaryotic cells also produce M-CSF in order to combat intercellular viral infection. (See colony-stimulating factor.) M-CSF binds to the macrophage colony-stimulating factor receptor. It may also be involved in development of the placenta.

Structure

It is a cytokine. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors.

Four transcript variants encoding three different isoforms have been found for this gene.

Further reading

• Stanley ER, Berg KL, Einstein DB; et al. (1995). "The biology and action of colony stimulating factor-1". Stem Cells. 12 Suppl 1: 15–24, discussion 25. PMID 7696959.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Alterman RL, Stanley ER (1994). "Colony stimulating factor-1 expression in human glioma". Mol. Chem. Neuropathol. 21 (2–3): 177–88. PMID 8086034.
• Stanley ER, Berg KL, Einstein DB; et al. (1997). "Biology and action of colony--stimulating factor-1". Mol. Reprod. Dev. 46 (1): 4–10. doi:10.1002/(SICI)1098-2795(199701)46:1<4::AID-MRD2>3.0.CO;2-V. PMID 8981357.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sweet MJ, Hume DA (2004). "CSF-1 as a regulator of macrophage activation and immune responses". Arch. Immunol. Ther. Exp. (Warsz.). 51 (3): 169–77. PMID 12894871.
• Mroczko B, Szmitkowski M (2005). "Hematopoietic cytokines as tumor markers". Clin. Chem. Lab. Med. 42 (12): 1347–54. doi:10.1515/CCLM.2004.253. PMID 15576295.
• Pandit J, Bohm A, Jancarik J; et al. (1993). "Three-dimensional structure of dimeric human recombinant macrophage colony-stimulating factor". Science. 258 (5086): 1358–62. PMID 1455231.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzu S, Ohtsuki T, Yanai N; et al. (1992). "Identification of a high molecular weight macrophage colony-stimulating factor as a glycosaminoglycan-containing species". J. Biol. Chem. 267 (7): 4345–8. PMID 1531650.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Saltman DL, Dolganov GM, Hinton LM, Lovett M (1992). "Reassignment of the human macrophage colony stimulating factor gene to chromosome 1p13-21". Biochem. Biophys. Res. Commun. 182 (3): 1139–43. PMID 1540160.CS1 maint: Multiple names: authors list (link)
• Praloran V, Chevalier S, Gascan H (1992). "Macrophage colony-stimulating factor is produced by activated T lymphocytes in vitro and is detected in vivo in T cells from reactive lymph nodes". Blood. 79 (9): 2500–1. PMID 1571567.CS1 maint: Multiple names: authors list (link)
• Price LK, Choi HU, Rosenberg L, Stanley ER (1992). "The predominant form of secreted colony stimulating factor-1 is a proteoglycan". J. Biol. Chem. 267 (4): 2190–9. PMID 1733926.CS1 maint: Multiple names: authors list (link)
• Pampfer S, Tabibzadeh S, Chuan FC, Pollard JW (1992). "Expression of colony-stimulating factor-1 (CSF-1) messenger RNA in human endometrial glands during the menstrual cycle: molecular cloning of a novel transcript that predicts a cell surface form of CSF-1". Mol. Endocrinol. 5 (12): 1931–8. PMID 1791839.CS1 maint: Multiple names: authors list (link)
• Stein J, Borzillo GV, Rettenmier CW (1990). "Direct stimulation of cells expressing receptors for macrophage colony-stimulating factor (CSF-1) by a plasma membrane-bound precursor of human CSF-1". Blood. 76 (7): 1308–14. PMID 2145044.CS1 maint: Multiple names: authors list (link)
• Sherr CJ, Rettenmier CW, Sacca R; et al. (1985). "The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF-1". Cell. 41 (3): 665–76. PMID 2408759.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cerretti DP, Wignall J, Anderson D; et al. (1988). "Human macrophage-colony stimulating factor: alternative RNA and protein processing from a single gene". Mol. Immunol. 25 (8): 761–70. PMID 2460758.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Takahashi M, Hirato T, Takano M; et al. (1989). "Amino-terminal region of human macrophage colony-stimulating factor (M-CSF) is sufficient for its in vitro biological activity: molecular cloning and expression of carboxyl-terminal deletion mutants of human M-CSF". Biochem. Biophys. Res. Commun. 161 (2): 892–901. PMID 2660794.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kawasaki ES, Ladner MB, Wang AM; et al. (1985). "Molecular cloning of a complementary DNA encoding human macrophage-specific colony-stimulating factor (CSF-1)". Science. 230 (4723): 291–6. PMID 2996129.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rettenmier CW, Roussel MF, Ashmun RA; et al. (1987). "Synthesis of membrane-bound colony-stimulating factor 1 (CSF-1) and downmodulation of CSF-1 receptors in NIH 3T3 cells transformed by cotransfection of the human CSF-1 and c-fms (CSF-1 receptor) genes". Mol. Cell. Biol. 7 (7): 2378–87. PMID 3039346.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Takahashi M, Hong YM, Yasuda S; et al. (1988). "Macrophage colony-stimulating factor is produced by human T lymphoblastoid cell line, CEM-ON: identification by amino-terminal amino acid sequence analysis". Biochem. Biophys. Res. Commun. 152 (3): 1401–9. PMID 3259875.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rettenmier CW, Roussel MF (1989). "Differential processing of colony-stimulating factor 1 precursors encoded by two human cDNAs". Mol. Cell. Biol. 8 (11): 5026–34. PMID 3264877.
• Wong GG, Temple PA, Leary AC; et al. (1987). "Human CSF-1: molecular cloning and expression of 4-kb cDNA encoding the human urinary protein". Science. 235 (4795): 1504–8. PMID 3493529.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• Granulocyte-Macrophage+Colony-Stimulating+Factor at the US National Library of Medicine Medical Subject Headings (MeSH)

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