MYO1A

Myosin IA
Identifiers
Symbols	MYO1A ; MIHC; BBMI; DFNA48; MYHL
External IDs	Template:OMIM5 Template:MGI HomoloGene: 21113
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE MYO1A 211916 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Myosin IA, also known as Brush-border myosin-1 and MYO1A, is a human gene.

The protein encoded by this gene belongs to the myosin superfamily. Myosins are molecular motors that, upon interaction with actin filaments, utilize energy from ATP hydrolysis to generate mechanical force. Each myosin has a conserved N-terminal motor domain that contains both ATP-binding and actin-binding sequences. Following the motor domain is a light-chain-binding 'neck' region containing 1-6 copies of a repeat element, the IQ motif, that serves as a binding site for calmodulin or other members of the EF-hand superfamily of calcium-binding proteins. At the C-terminus, each myosin class has a distinct tail domain that serves in dimerization, membrane binding, protein binding, and/or enzymatic activities and targets each myosin to its particular subcellular location. The kidney epithelial cell line, LLC-PK1-CL4 (CL4), forms a well ordered brush border (BB) on its apical surface. Experiments indicate that the brush border population of the encoded protein turns over rapidly, while its head and tail domains interact transiently with the core actin and plasma membrane, respectively. A rapidly exchanging pool of the protein encoded by this gene envelops an actin core bundle that, by comparison, is static in structure.

Further reading

• Hofmann WA, Johnson T, Klapczynski M; et al. (2007). "From transcription to transport: emerging roles for nuclear myosin I.". Biochem. Cell Biol. 84 (4): 418–26. doi:10.1139/o06-069. PMID 16936815.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hoshimaru M, Fujio Y, Sobue K; et al. (1990). "Immunochemical evidence that myosin I heavy chain-like protein is identical to the 110-kilodalton brush-border protein". J. Biochem. 106 (3): 455–9. PMID 2606897.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bement WM, Hasson T, Wirth JA; et al. (1994). "Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types". Proc. Natl. Acad. Sci. U.S.A. 91 (14): 6549–53. PMID 8022818.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Durrbach A, Collins K, Matsudaira P; et al. (1996). "Brush border myosin-I truncated in the motor domain impairs the distribution and the function of endocytic compartments in an hepatoma cell line". Proc. Natl. Acad. Sci. U.S.A. 93 (14): 7053–8. PMID 8692943.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hasson T, Skowron JF, Gilbert DJ; et al. (1997). "Mapping of unconventional myosins in mouse and human". Genomics. 36 (3): 431–9. doi:10.1006/geno.1996.0488. PMID 8884266.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Skowron JF, Bement WM, Mooseker MS (1999). "Human brush border myosin-I and myosin-Ic expression in human intestine and Caco-2BBe cells". Cell Motil. Cytoskeleton. 41 (4): 308–24. doi:10.1002/(SICI)1097-0169(1998)41:4<308::AID-CM4>3.0.CO;2-J. PMID 9858156.CS1 maint: Multiple names: authors list (link)
• Li W, Wang J, Coluccio LM; et al. (2000). "Brush border myosin I (BBMI): a basally localized transcript in human jejunal enterocytes". J. Histochem. Cytochem. 48 (1): 89–94. PMID 10653589.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Otterbein LR, Graceffa P, Dominguez R (2001). "The crystal structure of uncomplexed actin in the ADP state". Science. 293 (5530): 708–11. doi:10.1126/science.1059700. PMID 11474115.CS1 maint: Multiple names: authors list (link)
• Tyska MJ, Mooseker MS (2002). "MYO1A (brush border myosin I) dynamics in the brush border of LLC-PK1-CL4 cells". Biophys. J. 82 (4): 1869–83. PMID 11916846.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• D'Adamo P, Pinna M, Capobianco S; et al. (2003). "A novel autosomal dominant non-syndromic deafness locus (DFNA48) maps to 12q13-q14 in a large Italian family". Hum. Genet. 112 (3): 319–20. doi:10.1007/s00439-002-0880-6. PMID 12596055.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Donaudy F, Ferrara A, Esposito L; et al. (2003). "Multiple mutations of MYO1A, a cochlear-expressed gene, in sensorineural hearing loss". Am. J. Hum. Genet. 72 (6): 1571–7. PMID 12736868.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)