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{{Infobox_gene}}
{{PBB_Controls
'''Myosin X''', also known as '''MYO10''', is a [[protein]] that in humans is encoded by the ''MYO10'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MYO10 myosin X| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4651| accessdate = }}</ref><ref name="pmid8022818">{{cite journal | vauthors = Bement WM, Hasson T, Wirth JA, Cheney RE, Mooseker MS | title = Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 91 | issue = 14 | pages = 6549–53 | date = Jul 1994 | pmid = 8022818 | pmc = 44240 | doi = 10.1073/pnas.91.14.6549 | url = http://www.pnas.org/cgi/pmidlookup?view=long&pmid=8022818 }}</ref><ref name="pmid8884266">{{cite journal | vauthors = Hasson T, Skowron JF, Gilbert DJ, Avraham KB, Perry WL, Bement WM, Anderson BL, Sherr EH, Chen ZY, Greene LA, Ward DC, Corey DP, Mooseker MS, Copeland NG, Jenkins NA | title = Mapping of unconventional myosins in mouse and human | journal = Genomics | volume = 36 | issue = 3 | pages = 431–9 | date = Sep 1996 | pmid = 8884266 | doi = 10.1006/geno.1996.0488 }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Myosin X is an [[actin]]-based [[motor protein]] known to associate at the tips of [[filopodia]].<ref name="pmid11854753">{{cite journal | vauthors = Berg JS, Cheney RE | title = Myosin-X is an unconventional myosin that undergoes intrafilopodial motility | journal = Nature Cell Biology | volume = 4 | issue = 3 | pages = 246–50 | date = Mar 2002 | pmid = 11854753 | doi = 10.1038/ncb762 }}</ref>
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Myosin X
| HGNCid = 7593
| Symbol = MYO10
| AltSymbols =; FLJ10639; FLJ21066; FLJ22268; FLJ43256; KIAA0799; MGC131988
| OMIM = 601481
| ECnumber = 
| Homologene = 36328
| MGIid = 107716
| GeneAtlas_image1 = PBB_GE_MYO10_201976_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_MYO10_216222_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003774 |text = motor activity}} {{GNF_GO|id=GO:0003779 |text = actin binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}}
| Component = {{GNF_GO|id=GO:0005856 |text = cytoskeleton}} {{GNF_GO|id=GO:0016459 |text = myosin complex}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4651
    | Hs_Ensembl = ENSG00000145555
    | Hs_RefseqProtein = NP_036466
    | Hs_RefseqmRNA = NM_012334
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 16718413
    | Hs_GenLoc_end = 16989372
    | Hs_Uniprot = Q9HD67
    | Mm_EntrezGene = 17909
    | Mm_Ensembl = ENSMUSG00000022272
    | Mm_RefseqmRNA = XM_001006806
    | Mm_RefseqProtein = XP_001006806
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 15
    | Mm_GenLoc_start = 25567651
    | Mm_GenLoc_end = 25758396
    | Mm_Uniprot = 
  }}
}}
'''Myosin X''', also known as '''MYO10''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MYO10 myosin X| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4651| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Model organisms ==
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
[[Model organism]]s have been used in the study of MYO10 function. A conditional [[knockout mouse]] line called ''Myo10<sup>tm2(KOMP)Wtsi</sup>'' was generated at the [[Wellcome Trust Sanger Institute]].<ref name="mgp_reference">{{cite journal |title=The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice |author=Gerdin AK |year=2010 |journal=Acta Ophthalmologica|volume=88 |pages=925–7|doi=10.1111/j.1755-3768.2010.4142.x }}</ref> Male and female animals underwent a standardized [[phenotypic screen]]<ref name="IMPCsearch_ref">{{cite web |url=http://www.mousephenotype.org/data/search?q=Myo10#fq=*:*&facet=gene |title=International Mouse Phenotyping Consortium}}</ref> to determine the effects of deletion.<ref name="pmid21677750">{{cite journal | vauthors = Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A | title = A conditional knockout resource for the genome-wide study of mouse gene function | journal = Nature | volume = 474 | issue = 7351 | pages = 337–42 | date = Jun 2011 | pmid = 21677750 | pmc = 3572410 | doi = 10.1038/nature10163 }}</ref><ref name="mouse_library">{{cite journal | vauthors = Dolgin E | title = Mouse library set to be knockout | journal = Nature | volume = 474 | issue = 7351 | pages = 262–3 | date = Jun 2011 | pmid = 21677718 | doi = 10.1038/474262a }}</ref><ref name="mouse_for_all_reasons">{{cite journal | vauthors = Collins FS, Rossant J, Wurst W | title = A mouse for all reasons | journal = Cell | volume = 128 | issue = 1 | pages = 9–13 | date = Jan 2007 | pmid = 17218247 | doi = 10.1016/j.cell.2006.12.018 }}</ref><ref name="pmid23870131">{{cite journal | vauthors = White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP | title = Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes | journal = Cell | volume = 154 | issue = 2 | pages = 452–64 | date = Jul 2013 | pmid = 23870131 | pmc = 3717207 | doi = 10.1016/j.cell.2013.06.022 }}</ref> Additional screens performed:  - In-depth immunological phenotyping<ref name="iii_ref">{{cite web |url= http://www.immunophenotyping.org/data/search?keys=Myo10&field_gene_construct_tid=All |title=Infection and Immunity Immunophenotyping (3i) Consortium}}</ref>
{{reflist|2}}
{| class="wikitable sortable collapsible collapsed" border="1" cellpadding="2" style="float: left;" |
==Further reading==
|+ ''Myo10'' knockout mouse phenotype
|-
! Characteristic!! Phenotype
|-
| colspan=2; style="text-align: center;" | All data available at.<ref name="IMPCsearch_ref"/><ref name="iii_ref" />
 
|-
| Peripheral blood leukocytes 6 Weeks || bgcolor="#C40000"|Abnormal
 
|-
| ''[[Haematology]]'' 6 Weeks || bgcolor="#488ED3"|Normal
 
|-
| Insulin || bgcolor="#488ED3"|Normal
 
|-
| Homozygous viability at P14 || bgcolor="#488ED3"|Normal
 
|-
| Homozygous Fertility || bgcolor="#488ED3"|Normal
 
|-
| General Observations || bgcolor="#C40000"|Abnormal
 
|-
| Body weight || bgcolor="#488ED3"|Normal
 
|-
| Neurological assessment || bgcolor="#488ED3"|Normal
 
|-
| Grip strength || bgcolor="#488ED3"|Normal
 
|-
| [[Dysmorphology]] || bgcolor="#C40000"|Abnormal
 
|-
| [[Indirect calorimetry]] || bgcolor="#488ED3"|Normal
 
|-
| [[Glucose tolerance test]] || bgcolor="#488ED3"|Normal
 
|-
| [[Auditory brainstem response]] || bgcolor="#488ED3"|Normal
 
|-
| [[Dual-energy X-ray absorptiometry|DEXA]] || bgcolor="#488ED3"|Normal
 
|-
| [[Radiography]] || bgcolor="#488ED3"|Normal
 
|-
| Eye morphology || bgcolor="#C40000"|Abnormal
 
|-
| [[Clinical chemistry]] || bgcolor="#488ED3"|Normal
 
|-
| ''[[Haematology]]'' 16 Weeks || bgcolor="#488ED3"|Normal
 
|-
| Peripheral blood leukocytes 16 Weeks || bgcolor="#488ED3"|Normal
 
|-
| Heart weight || bgcolor="#488ED3"|Normal
 
|-
| ''[[Salmonella]]'' infection || bgcolor="#488ED3"|Normal
 
|-
| Cytotoxic T Cell Function || bgcolor="#488ED3"|Normal
 
|-
| Spleen Immunophenotyping || bgcolor="#488ED3"|Normal
 
|-
| Mesenteric Lymph Node Immunophenotyping || bgcolor="#488ED3"|Normal
 
|-
| Epidermal Immune Composition || bgcolor="#488ED3"|Normal
 
|-
| Influenza Challenge || bgcolor="#488ED3"|Normal
 
|-
|}
{{clear|left}}
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Hasson T, Skowron JF, Gilbert DJ, Avraham KB, Perry WL, Bement WM, Anderson BL, Sherr EH, Chen ZY, Greene LA, Ward DC, Corey DP, Mooseker MS, Copeland NG, Jenkins NA | title = Mapping of unconventional myosins in mouse and human | journal = Genomics | volume = 36 | issue = 3 | pages = 431–9 | date = Sep 1996 | pmid = 8884266 | doi = 10.1006/geno.1996.0488 }}
| citations =
* {{cite journal | vauthors = Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Research | volume = 5 | issue = 5 | pages = 277–86 | date = Oct 1998 | pmid = 9872452 | doi = 10.1093/dnares/5.5.277 }}
*{{cite journal | author=Hasson T, Skowron JF, Gilbert DJ, ''et al.'' |title=Mapping of unconventional myosins in mouse and human. |journal=Genomics |volume=36 |issue= 3 |pages= 431-9 |year= 1997 |pmid= 8884266 |doi= 10.1006/geno.1996.0488 }}
* {{cite journal | vauthors = Rojas K, Serrano de la Peña L, Gallardo T, Simmons A, Nyce K, McGrath R, Considine E, Vasko AJ, Peterson E, Grady D, Cox R, Andrew LJ, Lovett M, Overhauser J, Williams CJ | title = Physical map and characterization of transcripts in the candidate interval for familial chondrocalcinosis at chromosome 5p15.1 | journal = Genomics | volume = 62 | issue = 2 | pages = 177–83 | date = Dec 1999 | pmid = 10610710 | doi = 10.1006/geno.1999.5997 }}
*{{cite journal | author=Nagase T, Ishikawa K, Suyama M, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 5 |pages= 277-86 |year= 1999 |pmid= 9872452 |doi= }}
* {{cite journal | vauthors = Berg JS, Derfler BH, Pennisi CM, Corey DP, Cheney RE | title = Myosin-X, a novel myosin with pleckstrin homology domains, associates with regions of dynamic actin | journal = Journal of Cell Science | volume = 113 Pt 19 | issue =  | pages = 3439–51 | date = Oct 2000 | pmid = 10984435 | doi =  | series = 113 }}
*{{cite journal | author=Rojas K, Serrano de la Peña L, Gallardo T, ''et al.'' |title=Physical map and characterization of transcripts in the candidate interval for familial chondrocalcinosis at chromosome 5p15.1. |journal=Genomics |volume=62 |issue= 2 |pages= 177-83 |year= 2000 |pmid= 10610710 |doi= 10.1006/geno.1999.5997 }}
* {{cite journal | vauthors = Rogers MS, Strehler EE | title = The tumor-sensitive calmodulin-like protein is a specific light chain of human unconventional myosin X | journal = The Journal of Biological Chemistry | volume = 276 | issue = 15 | pages = 12182–9 | date = Apr 2001 | pmid = 11278607 | doi = 10.1074/jbc.M010056200 }}
*{{cite journal | author=Berg JS, Derfler BH, Pennisi CM, ''et al.'' |title=Myosin-X, a novel myosin with pleckstrin homology domains, associates with regions of dynamic actin. |journal=J. Cell. Sci. |volume=113 Pt 19 |issue=  |pages= 3439-51 |year= 2000 |pmid= 10984435 |doi=  }}
* {{cite journal | vauthors = Cox D, Berg JS, Cammer M, Chinegwundoh JO, Dale BM, Cheney RE, Greenberg S | title = Myosin X is a downstream effector of PI(3)K during phagocytosis | journal = Nature Cell Biology | volume = 4 | issue = 7 | pages = 469–77 | date = Jul 2002 | pmid = 12055636 | doi = 10.1038/ncb805 }}
*{{cite journal | author=Rogers MS, Strehler EE |title=The tumor-sensitive calmodulin-like protein is a specific light chain of human unconventional myosin X. |journal=J. Biol. Chem. |volume=276 |issue= 15 |pages= 12182-9 |year= 2001 |pmid= 11278607 |doi= 10.1074/jbc.M010056200 }}
* {{cite journal | vauthors = Navarro-Lérida I, Martínez Moreno M, Roncal F, Gavilanes F, Albar JP, Rodríguez-Crespo I | title = Proteomic identification of brain proteins that interact with dynein light chain LC8 | journal = Proteomics | volume = 4 | issue = 2 | pages = 339–46 | date = Feb 2004 | pmid = 14760703 | doi = 10.1002/pmic.200300528 }}
*{{cite journal | author=Cox D, Berg JS, Cammer M, ''et al.'' |title=Myosin X is a downstream effector of PI(3)K during phagocytosis. |journal=Nat. Cell Biol. |volume=4 |issue= 7 |pages= 469-77 |year= 2002 |pmid= 12055636 |doi= 10.1038/ncb805 }}
* {{cite journal | vauthors = Zhang H, Berg JS, Li Z, Wang Y, Lång P, Sousa AD, Bhaskar A, Cheney RE, Strömblad S | title = Myosin-X provides a motor-based link between integrins and the cytoskeleton | journal = Nature Cell Biology | volume = 6 | issue = 6 | pages = 523–31 | date = Jun 2004 | pmid = 15156152 | doi = 10.1038/ncb1136 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Tokuo H, Ikebe M | title = Myosin X transports Mena/VASP to the tip of filopodia | journal = Biochemical and Biophysical Research Communications | volume = 319 | issue = 1 | pages = 214–20 | date = Jun 2004 | pmid = 15158464 | doi = 10.1016/j.bbrc.2004.04.167 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | title = Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes | journal = Genome Research | volume = 16 | issue = 1 | pages = 55–65 | date = Jan 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }}
*{{cite journal  | author=Navarro-Lérida I, Martínez Moreno M, Roncal F, ''et al.'' |title=Proteomic identification of brain proteins that interact with dynein light chain LC8. |journal=Proteomics |volume=4 |issue= 2 |pages= 339-46 |year= 2004 |pmid= 14760703 |doi= 10.1002/pmic.200300528 }}
* {{cite journal | vauthors = Sousa AD, Berg JS, Robertson BW, Meeker RB, Cheney RE | title = Myo10 in brain: developmental regulation, identification of a headless isoform and dynamics in neurons | journal = Journal of Cell Science | volume = 119 | issue = Pt 1 | pages = 184–94 | date = Jan 2006 | pmid = 16371656 | doi = 10.1242/jcs.02726 }}
*{{cite journal | author=Zhang H, Berg JS, Li Z, ''et al.'' |title=Myosin-X provides a motor-based link between integrins and the cytoskeleton. |journal=Nat. Cell Biol. |volume=6 |issue= 6 |pages= 523-31 |year= 2004 |pmid= 15156152 |doi= 10.1038/ncb1136 }}
* {{cite journal | vauthors = Bohil AB, Robertson BW, Cheney RE | title = Myosin-X is a molecular motor that functions in filopodia formation | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 103 | issue = 33 | pages = 12411–6 | date = Aug 2006 | pmid = 16894163 | pmc = 1567893 | doi = 10.1073/pnas.0602443103 }}
*{{cite journal | author=Tokuo H, Ikebe M |title=Myosin X transports Mena/VASP to the tip of filopodia. |journal=Biochem. Biophys. Res. Commun. |volume=319 |issue= 1 |pages= 214-20 |year= 2004 |pmid= 15158464 |doi= 10.1016/j.bbrc.2004.04.167 }}
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | date = Nov 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal | author=Sousa AD, Berg JS, Robertson BW, ''et al.'' |title=Myo10 in brain: developmental regulation, identification of a headless isoform and dynamics in neurons. |journal=J. Cell. Sci. |volume=119 |issue= Pt 1 |pages= 184-94 |year= 2006 |pmid= 16371656 |doi= 10.1242/jcs.02726 }}
*{{cite journal | author=Bohil AB, Robertson BW, Cheney RE |title=Myosin-X is a molecular motor that functions in filopodia formation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 33 |pages= 12411-6 |year= 2006 |pmid= 16894163 |doi= 10.1073/pnas.0602443103 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
}}
{{refend}}
{{refend}}
{{protein-stub}}
{{WikiDoc Sources}}

Latest revision as of 07:14, 4 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

n/a

n/a

UniProt

n/a

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RefSeq (mRNA)

n/a

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Myosin X, also known as MYO10, is a protein that in humans is encoded by the MYO10 gene.[1][2][3]

Myosin X is an actin-based motor protein known to associate at the tips of filopodia.[4]

Model organisms

Model organisms have been used in the study of MYO10 function. A conditional knockout mouse line called Myo10tm2(KOMP)Wtsi was generated at the Wellcome Trust Sanger Institute.[5] Male and female animals underwent a standardized phenotypic screen[6] to determine the effects of deletion.[7][8][9][10] Additional screens performed: - In-depth immunological phenotyping[11]

References

  1. ↑ "Entrez Gene: MYO10 myosin X".
  2. ↑ Bement WM, Hasson T, Wirth JA, Cheney RE, Mooseker MS (Jul 1994). "Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types". Proceedings of the National Academy of Sciences of the United States of America. 91 (14): 6549–53. doi:10.1073/pnas.91.14.6549. PMC 44240. PMID 8022818.
  3. ↑ Hasson T, Skowron JF, Gilbert DJ, Avraham KB, Perry WL, Bement WM, Anderson BL, Sherr EH, Chen ZY, Greene LA, Ward DC, Corey DP, Mooseker MS, Copeland NG, Jenkins NA (Sep 1996). "Mapping of unconventional myosins in mouse and human". Genomics. 36 (3): 431–9. doi:10.1006/geno.1996.0488. PMID 8884266.
  4. ↑ Berg JS, Cheney RE (Mar 2002). "Myosin-X is an unconventional myosin that undergoes intrafilopodial motility". Nature Cell Biology. 4 (3): 246–50. doi:10.1038/ncb762. PMID 11854753.
  5. ↑ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
  6. ↑ 6.0 6.1 "International Mouse Phenotyping Consortium".
  7. ↑ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  8. ↑ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  9. ↑ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
  10. ↑ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (Jul 2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell. 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMC 3717207. PMID 23870131.
  11. ↑ 11.0 11.1 "Infection and Immunity Immunophenotyping (3i) Consortium".

Further reading

  • Hasson T, Skowron JF, Gilbert DJ, Avraham KB, Perry WL, Bement WM, Anderson BL, Sherr EH, Chen ZY, Greene LA, Ward DC, Corey DP, Mooseker MS, Copeland NG, Jenkins NA (Sep 1996). "Mapping of unconventional myosins in mouse and human". Genomics. 36 (3): 431–9. doi:10.1006/geno.1996.0488. PMID 8884266.
  • Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Oct 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
  • Rojas K, Serrano de la Peña L, Gallardo T, Simmons A, Nyce K, McGrath R, Considine E, Vasko AJ, Peterson E, Grady D, Cox R, Andrew LJ, Lovett M, Overhauser J, Williams CJ (Dec 1999). "Physical map and characterization of transcripts in the candidate interval for familial chondrocalcinosis at chromosome 5p15.1". Genomics. 62 (2): 177–83. doi:10.1006/geno.1999.5997. PMID 10610710.
  • Berg JS, Derfler BH, Pennisi CM, Corey DP, Cheney RE (Oct 2000). "Myosin-X, a novel myosin with pleckstrin homology domains, associates with regions of dynamic actin". Journal of Cell Science. 113. 113 Pt 19: 3439–51. PMID 10984435.
  • Rogers MS, Strehler EE (Apr 2001). "The tumor-sensitive calmodulin-like protein is a specific light chain of human unconventional myosin X". The Journal of Biological Chemistry. 276 (15): 12182–9. doi:10.1074/jbc.M010056200. PMID 11278607.
  • Cox D, Berg JS, Cammer M, Chinegwundoh JO, Dale BM, Cheney RE, Greenberg S (Jul 2002). "Myosin X is a downstream effector of PI(3)K during phagocytosis". Nature Cell Biology. 4 (7): 469–77. doi:10.1038/ncb805. PMID 12055636.
  • Navarro-Lérida I, Martínez Moreno M, Roncal F, Gavilanes F, Albar JP, Rodríguez-Crespo I (Feb 2004). "Proteomic identification of brain proteins that interact with dynein light chain LC8". Proteomics. 4 (2): 339–46. doi:10.1002/pmic.200300528. PMID 14760703.
  • Zhang H, Berg JS, Li Z, Wang Y, Lång P, Sousa AD, Bhaskar A, Cheney RE, Strömblad S (Jun 2004). "Myosin-X provides a motor-based link between integrins and the cytoskeleton". Nature Cell Biology. 6 (6): 523–31. doi:10.1038/ncb1136. PMID 15156152.
  • Tokuo H, Ikebe M (Jun 2004). "Myosin X transports Mena/VASP to the tip of filopodia". Biochemical and Biophysical Research Communications. 319 (1): 214–20. doi:10.1016/j.bbrc.2004.04.167. PMID 15158464.
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