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{{Infobox_gene}}
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'''Myosin light chain 3, skeletal muscle isoform''' is a [[protein]] that in humans is encoded by the ''MYL1'' [[gene]].<ref name="pmid2304459">{{cite journal |vauthors=Hailstones DL, Gunning PW | title = Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function | journal = Mol Cell Biol | volume = 10 | issue = 3 | pages = 1095–104 |date=Mar 1990 | pmid = 2304459 | pmc = 360973 | doi =  }}</ref><ref name="pmid3422212">{{cite journal |vauthors=Cohen-Haguenauer O, Barton PJ, Nguyen VC, Serero S, Gross MS, Jegou-Foubert C, de Tand MF, Robert B, Buckingham M, Frezal J | title = Assignment of the human fast skeletal muscle myosin alkali light chains gene (MLC1F/MLC3F) to 2q 32.1-2qter | journal = Hum Genet | volume = 78 | issue = 1 | pages = 65–70 |date=Mar 1988 | pmid = 3422212 | pmc =  | doi =10.1007/BF00291237 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MYL1 myosin, light chain 1, alkali; skeletal, fast| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4632| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Myosin, light chain 1, alkali; skeletal, fast
| HGNCid = 7582
| Symbol = MYL1
| AltSymbols =; MLC1F; MLC3F
| OMIM = 160780
| ECnumber =
| Homologene = 23194
| MGIid = 97269
| GeneAtlas_image1 = PBB_GE_MYL1_209888_s_at_tn.png
  | Function = {{GNF_GO|id=GO:0003774 |text = motor activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0008307 |text = structural constituent of muscle}}
| Component = {{GNF_GO|id=GO:0005859 |text = muscle myosin complex}} {{GNF_GO|id=GO:0016459 |text = myosin complex}}
| Process = {{GNF_GO|id=GO:0007517 |text = muscle development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4632
    | Hs_Ensembl = ENSG00000168530
    | Hs_RefseqProtein = NP_524144
    | Hs_RefseqmRNA = NM_079420
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 210863119
    | Hs_GenLoc_end = 210888142
    | Hs_Uniprot = P06741
    | Mm_EntrezGene = 17901
    | Mm_Ensembl = ENSMUSG00000061816
    | Mm_RefseqmRNA = NM_021285
    | Mm_RefseqProtein = NP_067260
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 66857506
    | Mm_GenLoc_end = 66878240
    | Mm_Uniprot = Q545G5
  }}
}}
'''Myosin, light chain 1, alkali; skeletal, fast''', also known as '''MYL1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MYL1 myosin, light chain 1, alkali; skeletal, fast| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4632| accessdate = }}</ref>


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{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in fast skeletal muscle. Two transcript variants have been identified for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: MYL1 myosin, light chain 1, alkali; skeletal, fast| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4632| accessdate = }}</ref>
| summary_text = Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in fast skeletal muscle. Two transcript variants have been identified for this gene.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Kelly RG, Buckingham ME |title=Modular regulation of the MLC1F/3F gene and striated muscle diversity. |journal=Microsc. Res. Tech. |volume=50 |issue= 6 |pages= 510-21 |year= 2000 |pmid= 10998640 |doi= 10.1002/1097-0029(20000915)50:6<510::AID-JEMT8>3.0.CO;2-1 }}
*{{cite journal  |vauthors=Kelly RG, Buckingham ME |title=Modular regulation of the MLC1F/3F gene and striated muscle diversity |journal=Microsc. Res. Tech. |volume=50 |issue= 6 |pages= 510–21 |year= 2000 |pmid= 10998640 |doi= 10.1002/1097-0029(20000915)50:6<510::AID-JEMT8>3.0.CO;2-1 }}
*{{cite journal  | author=Hailstones DL, Gunning PW |title=Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function. |journal=Mol. Cell. Biol. |volume=10 |issue= 3 |pages= 1095-104 |year= 1990 |pmid= 2304459 |doi=  }}
*{{cite journal  | author=Seidel U |title=Alkali myosin light chains in man are encoded by a multigene family that includes the adult skeletal muscle, the embryonic or atrial, and nonsarcomeric isoforms |journal=Gene |volume=66 |issue= 1 |pages= 135–46 |year= 1988 |pmid= 2458299 |doi=10.1016/0378-1119(88)90231-4  |name-list-format=vanc| author2=Bober E  | author3=Winter B  | display-authors=3  | last4=Lenz  | first4=S  | last5=Lohse  | first5=P  | last6=Goedde  | first6=H  | last7=Grzeschik  | first7=K  | last8=Arnold  | first8=H }}
*{{cite journal  | author=Seidel U, Bober E, Winter B, ''et al.'' |title=Alkali myosin light chains in man are encoded by a multigene family that includes the adult skeletal muscle, the embryonic or atrial, and nonsarcomeric isoforms. |journal=Gene |volume=66 |issue= 1 |pages= 135-46 |year= 1988 |pmid= 2458299 |doi=  }}
*{{cite journal  |vauthors=Seidel U, Arnold HH |title=Identification of the functional promoter regions in the human gene encoding the myosin alkali light chains MLC1 and MLC3 of fast skeletal muscle |journal=J. Biol. Chem. |volume=264 |issue= 27 |pages= 16109–17 |year= 1989 |pmid= 2777779 |doi=  }}
*{{cite journal  | author=Seidel U, Arnold HH |title=Identification of the functional promoter regions in the human gene encoding the myosin alkali light chains MLC1 and MLC3 of fast skeletal muscle. |journal=J. Biol. Chem. |volume=264 |issue= 27 |pages= 16109-17 |year= 1989 |pmid= 2777779 |doi=  }}
*{{cite journal  | author=Seidel U |title=The complete nucleotide sequences of cDNA clones coding for human myosin light chains 1 and 3 |journal=Nucleic Acids Res. |volume=15 |issue= 12 |pages= 4989 |year= 1987 |pmid= 3601661 |doi=10.1093/nar/15.12.4989 | pmc=305934 |name-list-format=vanc| author2=Bober E | author3=Winter B | display-authors=3 | last4=Lenz  | first4=Susan  | last5=Lohse  | first5=Peter  | last6=Arnold  | first6=H.H. }}
*{{cite journal  | author=Cohen-Haguenauer O, Barton PJ, Nguyen VC, ''et al.'' |title=Assignment of the human fast skeletal muscle myosin alkali light chains gene (MLC1F/MLC3F) to 2q 32.1-2qter. |journal=Hum. Genet. |volume=78 |issue= 1 |pages= 65-70 |year= 1988 |pmid= 3422212 |doi=  }}
*{{cite journal  |vauthors=Kontrogianni-Konstantopoulos A, Huang SC, Benz EJ |title=A Nonerythroid Isoform of Protein 4.1R Interacts with Components of the Contractile Apparatus in Skeletal Myofibers |journal=Mol. Biol. Cell |volume=11 |issue= 11 |pages= 3805–17 |year= 2001 |pmid= 11071908 |doi= 10.1091/mbc.11.11.3805| pmc=15038 }}
*{{cite journal | author=Seidel U, Bober E, Winter B, ''et al.'' |title=The complete nucleotide sequences of cDNA clones coding for human myosin light chains 1 and 3. |journal=Nucleic Acids Res. |volume=15 |issue= 12 |pages= 4989 |year= 1987 |pmid= 3601661 |doi=  }}
*{{cite journal  | author=Ballweber E |title=Interaction of ADP-ribosylated actin with actin binding proteins |journal=FEBS Lett. |volume=508 |issue= 1 |pages= 131–5 |year= 2001 |pmid= 11707283 |doi=10.1016/S0014-5793(01)03040-X  |name-list-format=vanc| author2=Galla M  | author3=Aktories K  | display-authors=3  | last4=Yeoh  | first4=Sharon  | last5=Weeds  | first5=Alan G.  | last6=Mannherz  | first6=Hans Georg }}
*{{cite journal  | author=Kontrogianni-Konstantopoulos A, Huang SC, Benz EJ |title=A nonerythroid isoform of protein 4.1R interacts with components of the contractile apparatus in skeletal myofibers. |journal=Mol. Biol. Cell |volume=11 |issue= 11 |pages= 3805-17 |year= 2001 |pmid= 11071908 |doi=  }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Ballweber E, Galla M, Aktories K, ''et al.'' |title=Interaction of ADP-ribosylated actin with actin binding proteins. |journal=FEBS Lett. |volume=508 |issue= 1 |pages= 131-5 |year= 2001 |pmid= 11707283 |doi=  }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Rual JF |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |name-list-format=vanc| author2=Venkatesan K  | author3=Hao T  | display-authors=3  | last4=Hirozane-Kishikawa  | first4=Tomoko  | last5=Dricot  | first5=Amélie  | last6=Li  | first6=Ning  | last7=Berriz  | first7=Gabriel F.  | last8=Gibbons  | first8=Francis D.  | last9=Dreze  | first9=Matija }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Kimura K |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129  |name-list-format=vanc| author2=Wakamatsu A  | author3=Suzuki Y  | display-authors=3  | last4=Ota  | first4=T  | last5=Nishikawa  | first5=T  | last6=Yamashita  | first6=R  | last7=Yamamoto  | first7=J  | last8=Sekine  | first8=M  | last9=Tsuritani  | first9=K }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
}}
}}
{{refend}}
{{refend}}


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[[Category:EF-hand-containing proteins]]

Latest revision as of 07:12, 4 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Myosin light chain 3, skeletal muscle isoform is a protein that in humans is encoded by the MYL1 gene.[1][2][3]

Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in fast skeletal muscle. Two transcript variants have been identified for this gene.[3]

References

  1. ↑ Hailstones DL, Gunning PW (Mar 1990). "Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function". Mol Cell Biol. 10 (3): 1095–104. PMC 360973. PMID 2304459.
  2. ↑ Cohen-Haguenauer O, Barton PJ, Nguyen VC, Serero S, Gross MS, Jegou-Foubert C, de Tand MF, Robert B, Buckingham M, Frezal J (Mar 1988). "Assignment of the human fast skeletal muscle myosin alkali light chains gene (MLC1F/MLC3F) to 2q 32.1-2qter". Hum Genet. 78 (1): 65–70. doi:10.1007/BF00291237. PMID 3422212.
  3. ↑ 3.0 3.1 "Entrez Gene: MYL1 myosin, light chain 1, alkali; skeletal, fast".

Further reading



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